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Safety Concerns About Long-term Use of PDE Inhibitor Our partner from Semmelweis University in Neovasculostop project published a paper in the Experimental Eye Research Volume 243, June 2024, 109890 (https://lnkd.in/dT2wTzQ5) about the possible side effects of the prolonged use of phosphodiesterase (PDE) inhibitors in the retina. PDE inhibitors, such as vardenafil, are commonly known for treating erectile dysfunction by increasing blood flow. Recently, scientists have discovered that these medications might also protect the heart and other organs, especially in people with conditions like diabetes. However, our partner’s research suggests that using these drugs over a long period and in high doses could potentially harm the eyes. They conducted a study on Zucker Diabetic Fatty (ZDF) rats, which are often used to study diabetes in humans. These rats were given vardenafil over a long period. The rats developed a condition called gliosis, which is a sign of inflammation in the retina (the part of the eye that senses light). They also observed that the rats lost a significant number of photoreceptors, the cells in the retina responsible for vision. These changes suggest that prolonged use of PDE inhibitors can be toxic to the retina. These findings raise important questions about the safety of long-term, high-dose use of PDE inhibitors in humans as well. These results must be considered if non-selective PDE inhibitors are planned to be used for alternative indications in humans. A thorough toxicity study should be performed, and the dosing or the administration should be modified to decrease the unintended retinal side effects before such treatment is applied on human patients. #emmes #vichem #semmelweisuniversity #lcinnoconsult #experimentica #innovation #PDEinhibitors #publicate #NeoVasculoStop
