Nerviano Medical Sciences - Part of NMS Group’s Post

Nanopesticides, with their innovative formulations, aim to target pest management challenges with precision while mitigating the broader ecological impact. But what are their effects on non-target organisms?" We addressed it in our newest publication. Thrilled to share our newest contribution to the field of environmental science with the publication entitled "Effects of Three Tebuconazole Nanopesticides on the Survival of Daphnia magna", in ESN, https://lnkd.in/e4nDJiNZ I would like to extend my profound appreciations to my supervisor Jakub Hofman and co-authors, Rocío López-Cabeza, Jan Kotouček, Renato Grillo, Marek Koutný, Zuzana Bílková whose support and expertise have been fundamental in advancing this research.   We hope the findings will contribute to the responsible development and use of nanopesticides in agriculture.   #research #plantprotectionproducts #toxicology #nanotoxicology #nanoparticles #sustainableagriculturepractice #SSBD.

Although many people know about isotopes, few are aware of the word's origin. Originally coined in 1913 by the Scottish writer and pioneering female doctor Margaret Todd, it is derived from the Greek roots isos (ἴσος), meaning equal, and topos (τόπος), meaning "the same place." She proposed the term to British radiochemist Frederick Soddy to describe his concept of atoms of the same element with identical chemical properties but different atomic weights, in essence, occupying "the same place" in the periodic table of elements.   Stable isotope-labeled (SIL) compounds are those labeled with non-radioactive isotopes such as H-2, C-13, N-15 and O-18. They play important roles in the analysis of drug metabolites and agrochemicals, studies of reaction mechanisms and kinetics, and drug metabolism and pharmacokinetics (DMPK) research. Speak with one of GD3's experts to learn more about our deep experience in the synthesis of SIL-labeled compounds and how we can advance your drug discovery and development program. #medicinalchemistry  #DrugDiscovery   #GD3Services  https://lnkd.in/ezTBzjzk

Although many people know about isotopes, few are aware of the word's origin. Originally coined in 1913 by the Scottish writer and pioneering female doctor Margaret Todd, it is derived from the Greek roots isos (ἴσος), meaning equal, and topos (τόπος), meaning "the same place." She proposed the term to British radiochemist Frederick Soddy to describe his concept of atoms of the same element with identical chemical properties but different atomic weights, in essence, occupying "the same place" in the periodic table of elements.   Stable isotope-labeled (SIL) compounds are those labeled with non-radioactive isotopes such as H-2, C-13, N-15 and O-18. They play important roles in the analysis of drug metabolites and agrochemicals, studies of reaction mechanisms and kinetics, and drug metabolism and pharmacokinetics (DMPK) research. Speak with one of GD3's experts to learn more about our deep experience in the synthesis of SIL-labeled compounds and how we can advance your drug discovery and development program. #medicinalchemistry  #DrugDiscovery   #GD3Services  https://lnkd.in/ezTBzjzk

Although many people know about isotopes, few are aware of the word's origin. Originally coined in 1913 by the Scottish writer and pioneering female doctor Margaret Todd, it is derived from the Greek roots isos (ἴσος), meaning equal, and topos (τόπος), meaning "the same place." She proposed the term to British radiochemist Frederick Soddy to describe his concept of atoms of the same element with identical chemical properties but different atomic weights, in essence, occupying "the same place" in the periodic table of elements.   Stable isotope-labeled (SIL) compounds are those labeled with non-radioactive isotopes such as H-2, C-13, N-15 and O-18. They play important roles in the analysis of drug metabolites and agrochemicals, studies of reaction mechanisms and kinetics, and drug metabolism and pharmacokinetics (DMPK) research. Speak with one of GD3's experts to learn more about our deep experience in the synthesis of SIL-labeled compounds and how we can advance your drug discovery and development program. #medicinalchemistry  #DrugDiscovery   #GD3Services  https://lnkd.in/ezTBzjzk

Our collaborative review article reached 20 citations Achieved on October 18, 2024 Article: Stimuli-Responsive Polymers for Transdermal, Transmucosal and Ocular Drug Delivery DOI: 10.3390/pharmaceutics13122050 Intravenous infusions of medications are invasive, painful and stressful for patients and carry the risk of infections, tissue damage and other adverse reactions. In order to account for these disadvantages, alternative routes of drug delivery, such as transdermal, nasal, oromucosal, ocular and others, have been considered. Moreover, drug formulations have been modified in order to improve their storage stability, solubility, absorption and safety. Recently, stimuli-responsive polymers have been shown to achieve controlled release and enhance the bioavailability of multiple drugs. In this review, we discuss the most up-to-date use of stimuli-responsive materials in order to optimize the delivery of medications that are unstable to pH or undergo primary metabolism via transdermal, nasal, oromucosal and ocular routes. #SU #drugdelivery #review

https://lnkd.in/eVu5Bdiz, https://lnkd.in/e_fbrqii   Embarking on a profound journey within the realm of medicinal chemistry, I am driven by a deep passion to make a meaningful impact, particularly in addressing neglected tropical diseases (NTDs). For this commitment, I collaborate with the LPCR team at Aix-Marseille Université (France), working synergistically with our esteemed partners from the LBqT team at FIOCRUZ (Brazil). The invaluable financial support extended by MinCiencias - Colombia plays a pivotal role in propelling our shared goals forward. I take immense pride in actively contributing to the collective efforts aimed at combating NTDs. This collaborative endeavor extends beyond the laboratory, encompassing a multifaceted approach involving not only scientific research but also strategic partnerships. In sharing our research outcomes, I am eager to communicate both the anticipated successes and the lessons drawn from challenges, recognizing that every aspect contributes to our collective growth. My current focus revolves around advancing research for new treatments in leishmaniasis, a pursuit that involves navigating both the anticipated and less glamorous facets of the scientific journey. I remain excited about the prospect of shaping the future landscape of medicinal chemistry and contributing to a world where neglected tropical diseases are no longer overlooked.

The article reached 200 reads Achieved on October 12, 2024 Article: Обзор производных пиперидина и морфолина by Khamitova A. E., Berillo D. A. Overview of piperidine and morpholine derivatives as promising sources of biologically active compounds. Drug development & registration . 2023;12(2):44–54. (In Russ.) https://lnkd.in/eTR7E5nX The search for new, effective and safe pharmacologically active substances remains an urgent task in the field of pharmacy. Many compounds of the piperidine and morpholine series are widely used in medical practice and belong to an important group of biologically active compounds. An informational, literature search on the synthesis of new derivatives of piperidine and morpholine was carried out. The article summarizes the results of studies of new derivatives of piperidine and morpholine as potential sources of biologically active substances. The review is devoted to the relationship between the pharmacological activity of the N-derivatives of piperidine and morpholine in relation to various biological targets and the structure of the substance, the importance of the piperidine and morpholine rings in the design and development of drugs is highlighted. Piperidine and morpholine are considered as prerogative structures not only for increasing activity, but also for obtaining biological substances with desired therapeutic properties and improved pharmacokinetics. The literature review shows the current trend towards the study of morpholine and piperidine derivatives, reveals their high pharmacophore activity. The review will provide researchers with the necessary knowledge base to make chemical structural changes to the structures of drug leaders to enhance pharmacological activities. #KazNMU #SatbayevUniversity #SU #review #impact #synthesis #Pharma https://lnkd.in/dD5wqUjM

📣 Remember to register for the 11th International Conference on NanoToxicology - NanoTox 2024 💡 23-25 September 2024 in Venice, personnel from research and academic institutions as well as from industry, governmental agencies, and other relevant organizations will discuss topics from the nano-world such as: ✅ (Eco)Toxicity of advanced (nano)materials ✅ Hazard and exposure assessment, risk management and governance of advanced (nano)materials ✅ Grouping and reading-across ✅ New approach methodologies (NAMs) for risk assessment ✅ Sustainability assessment, Safe(r)-by-Design (SbD) and Safe-and-Sustainable-by-Design (SSbD) of advanced (nano)materials ✅ Toxicity Pathways: nano cell circuits underlying Adverse Outcome Pathways (AOP) and Mode-of-Action (MoA) ✅ Big data management and modeling solutions The conference is co-organized by h2020 SUNSHINE, HARMLESS & DIAGONAL. You can't miss it! 👉 Visit the website and register https://lnkd.in/dhjF7BPn #nanotox #conference #event #nanotoxicology #SSbD #sustainability #assessment #NAMs #AOP #risk #hazard #nano #nanomaterials #modeling #solution

Our collaborative review reached 3,500 reads Achieved on July 26, 2024 Article: Stimuli-Responsive Polymers for Transdermal, Transmucosal and Ocular Drug Delivery Briefly, conventional and widespread use, oral and intravenous routes of drug administration face a number of limitations. In particular, orally administered drugs undergo enzymatic degradation in the gastrointestinal tract and first-pass metabolism in the liver, which tend to decrease their bioavailability. Intravenous infusions of medications are invasive, painful and stressful for patients and carry the risk of infections, tissue damage and other adverse reactions. In order to account for these disadvantages, alternative routes of drug delivery, such as transdermal, nasal, oromucosal, ocular and others, have been considered. drug formulations have been modified in order to improve their storage stability, solubility, absorption and safety. Recently, stimuli-responsive polymers have been shown to achieve controlled release and enhance the bioavailability of multiple drugs. In this review, we discuss the most up-to-date use of stimuli-responsive materials in order to optimize the delivery of medications that are unstable to pH or undergo primary metabolism via transdermal, nasal, oromucosal and ocular routes. Release kinetics, diffusion parameters and permeation rate of the drug via the mucosa or skin are discussed as well. #review #drugdelivery #peptides #ocular #KazNMU

This research introduces a novel approach utilizing a NIR-light-activated and lysosomal-targeted Pt