Neuroscience School of Advanced Studies’ Post

Progressive neuronal cell loss in the brain is the pathological hallmark of several neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease and ALS. Animal and cellular modelling studies support that misfolded protein aggregation plays a crucial role in the neuronal vulnerability linked to neurodegeneration. Misfolded and aggregated proteins can affect many different intracellular mechanisms such as degradation pathways, mitochondrial function, membrane function and axonal transport. At Cellectricon, we create highly relevant disease models using different strategies to recapitulate various aspects of neurodegeneration, e.g. protein aggregation and cellular toxicity. By combining our expertise in proteopathy disease modelling with advanced technologies, such as high content imaging and optical electrophysiology, we create high quality assays for target and lead discovery. Our services have broad applications - from evaluation of a single gene or molecule to thousands of genes or compounds in a more regular screening context. Learn more about our services on: https://lnkd.in/edQ-5E88 #CRO #neuroscience #drugdiscovery #targetdiscovery #leaddiscovery #neurobiology #invitro #research #neurodegeneration #parkinsons #alzheimers

Worm Study Unlocks Key to Treating Alzheimer's and Parkinson's Researchers at Florida Atlantic University have discovered that the gene swip-10, studied in the roundworm Caenorhabditis elegans, plays a key role in copper regulation, which could lead to new treatments for neurodegenerative diseases like Parkinson'sand Alzheimer's The study links copper imbalance to neuron degeneration suggesting that restoring copper levels might prevent or slow disease progression. These findings highlight the importance of studying simple organisms to uncover potential therapeutic breakthroughs for complex human conditions like neurodegenerative disorders. #Neurodegeneration #AlzheimersResearch #ParkinsonsDisease #CopperBalance #Neuroscience #GeneticResearch #Swip10 #MedicalBreakthrough #FAUResearch #RoundwormStudy #BrainHealth #Neurotherapeutics #WissenResearch

By coupling mass spectrometry with cell type-specific in vivo biotinylation of proteins (CIBOP), Kumar et al. are able to resolve native state proteomes from physically unaltered cell subtypes in vivo. In their latest publication in nature communications (PMID 38561349), they identified potential molecular vulnerabilities of parvalbumin-expressing interneurons to neurodegeneration in Alzheimer’s disease using our guinea pig antibody against parvalbumin (195 004).   #neuroscience #antibodies #parvalbumin #CIBOP #Alzheimersdisease

Check out my Bioinforange - Bioinfocongress II 18-20 March 2022 digital certificate issued by Bioinforange via Sertifier! #sertifier #digitalbadge #digitalcertificate #digitalcredentials #scrna-seqdataanalysiswithr #mrnavaccines #vaccineresponses #sphingolipids #ribosomalframeshift #omictechnologies #neuroscience #neurodegeneration #innovativediseasetreatments #immunesystem #humantissuearchitecture #genomics #genomesecrecy #genomeorganization #genetic #drugrepurposing #diabetes #computeraideddrugdesign #computationlbiology #cellbiology #cancer #covid-19 #bioreactor #biophysics #biomimetic #biomedicalapproaches #bioinformatics #artificialintelligenceinhealth #alzheimer'sdisease #aging

Selective vulnerabilities within vascular subpopulations associated with clinically diagnosed Alzheimer's disease (AD) were unveiled in a recent research, revealing pivotal transcriptomic perturbations. Significantly, the study validates the expression of genes associated with AD risk, identified through genome-wide association studies (GWASs), across diverse human brain vascular cell types. This insight places these genes within the vascular context, shedding light on targeted therapeutic interventions. A fascinating study by Yang, et al. on Nature “A human brain vascular atlas reveals diverse mediators of Alzheimer’s risk.” #alzheimers #dementia #GWAS #snRNAseq #snRNA #singlenuclei #neuroscience #BioTuring Read the publication here: https://lnkd.in/gbW6Nzmw Explore the dataset on Talk2Data now: https://lnkd.in/gmfztFeJ 

Check out my Bioinforange - Bioinfocongress II 18-20 March 2022 digital certificate issued by Bioinforange via Sertifier! #sertifier #digitalbadge #digitalcertificate #digitalcredentials #scrna-seqdataanalysiswithr #mrnavaccines #vaccineresponses #sphingolipids #ribosomalframeshift #omictechnologies #neuroscience #neurodegeneration #innovativediseasetreatments #immunesystem #humantissuearchitecture #genomics #genomesecrecy #genomeorganization #genetic #drugrepurposing #diabetes #computeraideddrugdesign #computationlbiology #cellbiology #cancer #covid-19 #bioreactor #biophysics #biomimetic #biomedicalapproaches #bioinformatics #artificialintelligenceinhealth #alzheimer'sdisease #aging

Inflammation Exacerbates Neurodegeneration of a Lysosomal Storage Disease MPS IIIA is a rare childhood disorder characterized by the accumulation of heparan sulfate, leading to progressive brain damage and behavioral abnormalities. Researchers have investigated the role of inflammation in exacerbating disease progression. By administering a viral mimic, poly(I:C), to both wild-type and MPS IIIA mice, investigators observed increased inflammation and neuronal damage in the MPS IIIA group. These findings suggest a potential link between inflammation, particularly the cytokine IL-1β, and accelerated neurodegeneration in MPS IIIA. The article was published in Embo Mol Med: https://lnkd.in/e_ytc2je #genetics #genomics #precisionmedicine #genomicmedicine #raŕdisease #lysosome #inflammation #neuroinflammation #immunity #brain #neurology #neurodegeneration #neuroscience #biomarkers #therapeutics #biotechnology #Innovation #research #science #sciencecommunication

Peripheral neuropathies, including chronic pain and diabetic neuropathy, affect many patients and there is an urgent need for new treatments. Increasing the understanding of common underlying disease mechanisms provides an opportunity for advancing drug development. At Cellectricon, we have long-standing experience in supporting our clients in accelerating their drug discovery programs by providing in vitro services for target discovery and validation as well as lead discovery. In collaboration with leading industry partners, we have developed several in vitro disease models for assessing changes in key phenotypes, such as neuronal hyperexcitability and axonal outgrowth. Reach out to learn more about our platform for drug discovery and to explore how we may support your research. https://lnkd.in/eqmvGsrQ   #neuroscience #drugdiscovery #targetdiscovery #leaddiscovery #neurobiology #invitro #research #peripheralneuropathy #neuropathy

Astrocytic reprogramming at the border of traumatic lesions contributes to CNS repair CNS lesions acquire neuroprotective borders of reactive astrocytes, but their origin remains unclear. Following spinal cord injury or stroke in adult mice, the authors showed that 90% and 10% of border astrocytes arise from local astrocyte and oligodendrocyte progenitor proliferation. Temporal transcriptomics, single-nucleus RNA-seq, and IHC reveal dedifferentiation, proliferation, and sustained transcriptional reprogramming of local mature astrocytes after injury. These "wound repair astrocytes" exhibit downregulated astrocyte-neuron interactions and upregulated wound healing/immune-related genes. They share features with perimeningeal limitans astrocytes and represent the primary source of neuroprotective borders, re-establishing CNS integrity by isolating neural parenchyma from stromal/immune cells. The article, along with a commentary on the article was published in Nat Neurosc: https://lnkd.in/eHPg2q4f, https://lnkd.in/epN3QB6p. #genetics #genomics #precisionmedicine #genomicmedicine #brain #neurology #neuroscience #neurodegeneration #stroke #traumaticbraininjury #regenerativemedicine #astrocytes #oligodendrocytes #development #immunity #immunology #healing #neuroprotection #drugdevelopment #drugdiscovery #biomarkers #biotechnology #innovation #research #science #sciencecommunication

I am proud to announce an original article on the topic: Investigating the level of EGFR1 gene expression in the peripheral blood of Iranian patients with paranoid personality disorder and its relationship with neurological markers, a study of brain imaging was accepted and published at the 8th International Conference on Research in Science and Engineering in Bangkok, Thailand. The growth and development of science and the presentation of research results at international conferences is encouraging, and the feeling that you can help the world in this vast ocean of science is very gratifying. We hope for a day when there is no disease in this world and all diseases will be cured. 18 january, 2024 Kasem Bundit University, Bangkok, Thailand #neuroscience #genetics #science #neurodegenerativediseases #EGFR1gene #neurological