Exeliom Biosciences’ Post

Headlining this week's CHC.NewDirections, a CHC.Newsflash Extra: A new and freely available “Human Gut Microbiome Atlas” could help researchers and healthcare professionals around the world improve their understanding of the effects on illness of bacteria and other microorganisms in the gut microbiome, leading to more effective treatments. The King's College London-led study, said to be the largest of its kind to date, identified gut bacteria appearing in 6,014 individuals with 23 separate diseases across 19 countries. Using machine learning tools, the researchers classified gut bacteria that appeared most frequently in healthy people and people with specific diseases, tagging specific functions to specific bacteria. The researchers believe the data could help diagnose illness and provide individual pathways for treatment. According to corresponding author Dr Saeed Shoaie: “The lack of access to high-quality harmonised data has been a stumbling block for future impactful research. That’s why we created the Human Gut Microbiome Atlas.” The research team hopes to expand its work to produce oral and skin microbiome atlases to treat conditions such as eczema and psoriasis, as well as tracing antimicrobial resistance (AMR) in the gut. By tracing the gut bacteria that are becoming resistant to antibiotics within global populations and environments, the group hopes to improve and assess the efficacy of efforts to treat disease and combat AMR. Co-author Dr Frederick Clasen noted: “We believe that the human microbiome atlas is an important step to unlocking the power of microbiome for this purpose.” To read more of my thoughts on this and other key CHC headlines and developments, trial our combined news service by contacting Melissa #consumerhealthcare #CHC #CHCNewsflash #CHCNewDirections  #gut #microbiome #gutmicrobiome #gutbacteria

Carbon beads could be the key to treating liver disease and other health issues caused by a dysfunctional gut microbiome. "They work by absorbing the endotoxins and other metabolites produced by 'bad' bacteria in the gut, creating a better environment for the good bacteria to flourish and helping to restore microbiome health. This prevents these toxins from leaching into other areas of the body and causing damage, as they do in cirrhosis". With promising results in animal models, approval for treatment could be on the horizon thanks to funding from the EU's Horizon 2020 program. #Research #Innovation #HealthcareFuture #Horizon2020 #InnovateUK #Innovation #Patents https://lnkd.in/eBatxszx

🔬 𝗚𝘂𝘁 𝗠𝗶𝗰𝗿𝗼𝗯𝗶𝗼𝗺𝗲 𝗜𝗻𝘀𝗶𝗴𝗵𝘁𝘀 𝗶𝗻 𝗛𝗲𝗽𝗮𝘁𝗶𝗰 𝗖𝘆𝘀𝘁𝗶𝗰 𝗘𝗰𝗵𝗶𝗻𝗼𝗰𝗼𝗰𝗰𝗼𝘀𝗶𝘀 𝗦𝘁𝗮𝗴𝗲𝘀 🧫 Recent study analyzed the gut microbiomes of CE patients at different stages of the disease—active, transitional, and inactive—using high-throughput sequencing. Here’s what they found: • Patients with inactive CE stages exhibited the highest microbial frequencies, suggesting potential microbial stability or resistance against the progression of the disease. • Conversely, those in the active stages of CE showed significantly lower microbial diversity, indicating a possible link between reduced microbial diversity and increased disease activity or severity. • Notably, the genus Agathobacter, prevalent in inactive stages, could be pivotal in maintaining intestinal health and possibly mitigating disease progression due to its butyrate-producing capabilities. 🌐 This study advances our understanding of the microbial dynamics in parasitic infections and opens new avenues for microbiome-based therapeutic strategies. The correlation between microbial composition and disease stages could lead to tailored treatments that manage or even prevent the progression of CE. 📖 For a deeper dive into this fascinating research, check out the full article in Scientific Reports ⬇️ #microbiomeresearch #cysticechinococcosis #healthcareinnovation #parasiticdiseases

Population-based analysis identifying correlations between the #Neutrophil_to_Lymphocyte Ratio (NLR) and gut #microbiota within a generally normative #NLR range. Notably, the gut microbiome in individuals classified in the lower quartile (Q) of the NLR exhibited a greater richness in α-diversity. Furthermore, significant differences in β-diversity were observed among the various NLR groups, especially contrasting the lower Q group with the upper quartiles. Specifically, the relative abundance of #Bacteroides_eggerthii showed a positive correlation with NLR values, revealing significantly higher levels in the upper Q group compared to the lower and mid-range quartiles. Additionally, #Bilophila was found to be less prevalent in the lower Q group than in the higher Q group. While NLR serves as a prognostic marker across numerous diseases, its optimal cut-off values remain debated, particularly for mortality linked to specific conditions. Interestingly, This illustrate subtle differences in β-diversity even within the normal NLR range, suggesting that the microbiota composition may vary based on NLR classifications. This observation is especially pertinent in healthy populations where systemic inflammation is assessed through markers like NLR and #C_reactive_protein (CRP). While CRP is a reactive acute-phase protein reflecting inflammation, NLR may provide a more precise insight into immune function and inflammatory responses, highlighting its potential as a sensitive marker for microbe-mediated changes due to external influences such as immune activation or inflammation. RF: Association between Neutrophilto-Lymphocyte Ratio and Gut Microbiota in a Large Population: a Retrospective Cross-Sectional Study.

🐽In this explainer video, Merete Fredholm, Chair of the Host Pillar, professor from Københavns Universitet - University of Copenhagen, discusses the concepts of “#robustness” and “#resilience” in #pigs, as well as the key #biomarkers that the Host Pillar examines within PIG-PARADIGM . 🔬The Host Pillar is built on a #clinical and #pathological characterization of #intestinalhealth in a cohort of 2,500 pigs with the aim to differentiate unequivocally between the #phenotype of the #robust pig and the non-robust pig. By examining the interactions between the #gutmicrobiome and various #host factors, research in Host Pillar seeks to understand their individual and combined effects on intestinal health and resilience and identify biomarkers that predict intestinal disease predisposition at different stages of a pig's life. 👉Read more about the research in the Host Pillar on our website: https://lnkd.in/dT5GFZh5

Our latest paper was just released in Cell Reports and looks at the under-studied role of the phageome in the gut microbiome in cardiometabolic diseases. The phageome is made up of bacteriophages (phages), which are capable of influencing bacterial populations and function within the microbiome, thus influencing health outcomes. They could, therefore, be used to favourably modify the microbiome in health and disease and act as a reservoir for biomarkers. However, more research is needed. Here, we summarise fundings from studies investigating phages in cardiometabolic diseases and elaborate on the potential of phage-based therapies. Thanks to all the authors for their valuable contributions. https://lnkd.in/ewBdVs7B

Altered Microbiota: A New Culprit in Kidney Stone Development! In a recent study led by Western University, researchers have linked microbiota alteration to kidney stone development. Examining the gut, urinary, and oral microbiota in both kidney stone patients and healthy controls revealed a potential hallmark of the disease: multi-site microbiota disturbance. This discovery challenges conventional oxalate-focused approaches. Shifting focus to restoring microbial balance offers a promising strategy for more effective treatment and prevention, opening doors to tailored medical interventions that could greatly reduce kidney stone incidence and recurrence. Read more about this study: https://lnkd.in/dsAMGNQJ. Don't forget to join the 11th World Congress of the ISM to learn more about microbiota's impact on different diseases: https://lnkd.in/dJNYADQ. #InternationalSocietyofMicrobiota #TargetingMicrobiota2024 #ISM #microbiota #microbiome #kidney #kidneystones #gutdysbiosis

Fungi of the human gut microbiota: Roles and significance Fungi of the genus Candida (for instance C. albicans and C. parapsilosis) are typically referred to as opportunistic pathogens. Because they reside in the gut, it has been hypothesized that the intestinal microbiota may play a major role in Candida’s pathogenesis. Recent clinical evidence adds support to this notion. In patients with disseminated Candida infections, C. albicans and C. parapsilosis translocation into the bloodstream was found to be preceded by an expansion of both species in the gastrointestinal tract ). Furthermore, fungal dysbiosis was found to be tightly associated with bacterial dysbiosis, particularly the loss of anaerobic bacterial . While cause and effect are difficult to pinpoint, one may in the long term envision potential interventions that target the gut microbiome to inhibit Candida dissemination from the gastrointestinal tract in people at risk of infections, something that has yet to be achieved for fungal infections.

Two things 1. Great to see acknowledgement of the critical role the gut microbiome in our physical and mental health. Investing in regulatory (APVMA) oversight of the Agrotox industry may present a better public health outcome - prevention better than cure etc. 2. Be aware of the ask and whom is asking. Providing unique genetic information to a group with a corporate partner (Illumina) with $4.3b revenue last year would hopefully bear fruit when and if they get to commercialisation.

Great to see the initial data coming out of this study from Ohio State University that could help identify a link between gut health and the increased incidence of colon cancer in those under 50. Initial data from the study indicates that reduced levels of fibre & higher levels of sugar in an individual's food & drinks can increase levels of the gut bacteria Fusobacterium, which increases inflammation in the gut. "Sustained inflammation has been shown to 'age' cells, and the researchers estimated that regular poor diets in young colorectal cancer patients aged their cells by up to 15 years older than a person's biological age." "The team noted that the findings align with other recent data, suggesting that low-fiber, processed diets throw off the gut microbiome balance in a process called intestinal dysbiosis. The number of people under 50 being diagnosed with cancer in the UK has risen by 24 per cent in two decades, a sharper increase than any other age group, and doctors trying to work out what's behind the rapid rise have suspected for some time that modern diets are to blame in some way." https://buff.ly/4c94rBf