nRichDX’s Post

With cancer immunotherapy and precision medicine dynamically evolving, there is greater need for pre-clinical models that can better replicate the intact tumor and its complex tumor microenvironment (TME). Precision-cut tumor slices (PCTS) have recently emerged as an ex vivo human tumor model, offering the opportunity to study individual patient responses to targeted therapies, including immunotherapies p/b University of North Carolina at Chapel Hill, University of Pennsylvania, The Institute of Cancer Research, Caitlin Tilsed, Karthik Rajasekaran, Ph.D., Sunil Singhal, Steven Albelda, Astero KLAMPATSA #immunotherapy #translationalmedicine #tumormicroenvironment https://lnkd.in/gXJdDFjM

Biology Lesson of the day: Differences between cancer organoids and spheroids. Both spheroids and tumoroids offer valuable insights into tumor biology and drug responses, but their applications and limitations must be carefully considered. Read the article below to learn more.

Structural variants (SVs) are known drivers of cancer, however they are difficult to resolve due to their long and complex structure. In this case study, learn how researchers used nanopore sequencing to analyse structural variants in human paired colorectal cancer samples. Using long nanopore reads they revealed previously hidden genomic information suggesting that this method has the potential to detect novel fusions genes. These findings are important as they provide a new insight into the somatic mechanisms driving cancer. Read here: https://bit.ly/4astTRd #AACR #AACR24

Praise God for Fragmentomics! Too many of us have lost someone we love to cancer. Fragmentomics is helping detect cancer in stage 1 where survival rate is dramatically increased and studies show 5 years of life are added to someone we love. I was privileged to come into the healthcare software industry 18 years ago when many of the technologies and portals and interfaces had not yet been created. I am thankful for all the times God allowed me to be part of a beta team to expedite critical interfaces like Lab Portal Services and eprescribing to actual implementation. I pray that this week will be the week that all my friends who have been waiting to land and get back to doing their part to advancing critical studies like Fragmentomics so that together we can continue to bring greater is the week that we all get back to contributing! It is time that equity groups came up with new ideas for generating 25 to 50 million dollars to reinvest in bringing greater. There is nothing greater about stopping those who are invested in what we are all in this industry to do from being able to do their part to accomplish. Time is critical for our family members for whom we are all in this to bring greater and to help provide extra years to enjoy life together. Great companies could do a 20% RIF without the purchase of an equity company if the goal to bring better was to take several hundred of your top employees away from doing just that. I looked up what leadership at equity firms make. It is far more than what most of the top talent you release every time you have a RIF make. Yet, it is their great ideas in which you reinvest and take credit for it. How about doing a RIF of 10% of your employees after a purchase? You would easily generate just as much cash and have to cause fewer people to be out of work. It would flood the market a whole lot less. You could even take the 10% of top talent with actual ideas whom you would have otherwise released and put them in those positions at lower salaries. That is the goal anyway and you get to save money and truly generate great ideas for the next purchase. I give you my permission to use my great idea for bringing greater. Please dare to be different. Bring new ideas with you with the next purchase of a great company. Praise God for Fragmentomics! Everyone of my friends will land in a better place and will be part of greater life saving studies like Fragmentomics. To all the great companies out there! There is nothing wrong with selling to an equity group. Please just be sure to maintain control of decision making. If you make comments to your family that suggest there will be no changes to employment, stand behind it! You cannot put a price tag on trust! You worked too hard to earn it! Once you lose it, good luck getting it back!

The next UT Center for Computational Oncology #PaperOfTheWeek investigate cancer induced cachexia. Authors Suzan Farhang-Sardroodi, Michael A La Croix, and Kathleen Wilkie (Toronto Metropolitan Mathematics Alumni Group) offer a mathematical model of the effect of chemotherapy on muscle, lean mass, and the tumor. They then simulate alternate dosing schedules to protect lean mass while simultaneously targeting the tumor. Definitely worth a read--check it out: https://lnkd.in/gKxwgAw8

“These technologies have drastically improved our temporal understanding of disease biology because we can track clonal evolution, epigenetic modifications, and cellular mechanisms before, during, and after cancer and its treatment” - Todd Druley, MD, PhD In this article from Biocompare, learn more about how single-cell multi-omics technologies (like the Tapestri Platform) are advancing cancer research. 🔗 https://lnkd.in/epPgXAzX

A huge advantage to ultra long reads over short read technology! There is a big gap between the indels that can be resolved with Illumina massively parallel short read sequencing and larger CNVs that can be resolved by microarray. Nanopore's tech is a game changer for these understudied structural variants. There is another fascinating article by Ming Lei et. al. where a case of chromothrypsis in a complex genetic disorder was resolved with long nanopore reads. DOI is 10.1038/s10038-020-0754-6 if anyone is interested.

📰 “Damaged DNA in Colorectal Cancer Chemo Patients Might Be Repaired More Effectively with New Therapy” An international research team from the University of Oxford and Nanyang Technological University (NTU Singapore) reports the discovery of a new process for repairing damaged #DNA that is particularly relevant for patients undergoing colorectal #cancertreatments. 🔗Continue reading: https://bit.ly/4esJKkM University of Oxford Nanyang Technological University Singapore #LymphocyteEngineering #CART #Immunotherapy #PrecisionMedicine #CellTherapy #GeneEditing

Using cutting-edge technology, you will investigate the cell-intrinsic and cell-extrinsic drivers of AML. PhD candidate to study the bone marrow microenvironment in leukemia Erasmus Medical Center Cancer Institute See the full job description on jobRxiv: https://lnkd.in/d5jkgavr #single_cell_biology #spatial_multiomics #spatial_transcriptomics

Exploring the role of trifarotene against RAR-α: an investigation of expression pattern and clinicopathological significance of RAR-α in breast cancer