Nuffield Dept of Women's & Reproductive Health, University of Oxford’s Post

Long QT syndrome impacts thousands of patients every year. While the condition may be genetic, it can also be induced by medication. Acute prolongation of the QT interval is associated with an increased risk for potentially lethal dysrhythmias, such as torsades de pointes (TdP). Review the causes of QT prolongation and how to monitor long QT in this #ClinicalView article. #PatientMonitoring

post stroke cognitive recovery

Understanding the role of toxic amyloid precursor protein (APP), called APP-CTFs could open avenues for early intervention therapies that could stop or even prevent Alzheimer's disease. It's the excess of fragments of APP-CTFs, that can trigger a mechanism that occurs at the early stages of Alzheimer's disease. Study shows that amyloid-β and APP-CTF can accumulate in tandem with one another, but researchers have largely overlooked this.‘This knowledge can lead to a smarter drug design that both prevents the accumulation of toxic amyloid-β peptides and APP-CTFs,’ These could include γ-secretase modulators that stabilise – rather than turn off – the activity of γ-secretase, making shorter, non-toxic amyloids, and may prevent APP-CTF accumulation. https://lnkd.in/g5kPS5_A

Get your Lp(a) tested. PLEASE. "Lipoprotein(a) [Lp(a)] is a recognized risk factor for ischemic stroke" "A positive linear relationship between Lp(a) and IS risk was observed" "Elevated Lp(a) concentration was significantly associated with IS and SEE, suggesting that Lp(a) may be an emerging biomarker that can help clinicians identify patients at high risk of thromboembolism in this population." Predicting clots via elevated Lp(a) is still "controversial", yet the test can be done with any simple bloodwork. Get it done, cuz strokes are NOT fun. https://lnkd.in/gRgNutYc #heartattack #stroke

🔍Unlocking Pain Relief with Genetics! 🧬💡A genetic marker can predict how well gabapentin works for chronic pelvic pain! This breakthrough brings hope for tailored treatments. ➡️Read more: https://bit.ly/3zLXrfw 📈 Why is this important? Personalized medicine ensures that patients get the most effective relief with fewer side effects. 🌍 This could be a game-changer for pain management! 💪 👩⚕️ Healthcare professionals can leverage this discovery to improve patient outcomes. 📊 Stay ahead in the field by integrating genetic insights into your practice. 🏥 💬 Join the conversation! How do you think this will impact the future of pain treatment? 🤔 Share your thoughts and experiences below. ⬇️ Credit: @iScience journal #GeneticMarker #DNA #PelvicPain #PersonalizedMedicine #HealthcareInnovation #PainManagement #meded #eMednews

Our recent publication in Journal of Autoimmunity : This study links rare and common Chronic nonbacterial osteomyelitis-associated P2RX7 variants with altered inflammasome assembly, pro-inflammatory cytokine release, and reduced pyroptosis. #chronicnonbacterialosteomyelitis #autoinflammation #inflammation #pyroptosis

https://lnkd.in/ev-cq4ZB Our manuscript got published today! It revealed that Neutrophil Gelatinase-Associated Lipocalin (NGLA) had the highest predictive value for contrast-induced nephropathy, followed closely by cystatin-C and Urinary Kidney Injury Molecule-1 (uKIM-1).

GNSC-001 uses an rAAV vector to deliver an optimized form of IL-1Ra designed to block IL-1 signaling, which contributes to inflammation, joint pain, and cartilage destruction in knee #Osteoarthritis Genascence Corporation https://lnkd.in/e-KWr6er

The #ketogenic diet (KD) demonstrated promising outcomes in subacute acquired brain injury (ABI) patients. Efficient recruitment, rapid attainment of ketosis, and minimal adverse reactions signify its feasibility. These findings pave the way for future research to explore the potential therapeutic benefits of KD in ABI. Standardization of protocols and investigation into various formulations will be crucial for optimizing its efficacy. Full text: https://lnkd.in/dtpRny4e #ketodiet #ketogenicdiet #keto #chetoigenica #dietachetogenica

Diagnosis and treatment of multiple myeloma and AL amyloidosis with focus on improvement of renal lesion #EurekaMag