Today we announced a plan to advance OK-101 into a Phase 2 clinical trial of neuropathic corneal pain which is expected to begin in Q3 2024. This one-year study is supported by pre-clinical animal model data and statistically significant pain relief observed in OK-101’s first human trial recently conducted in DED patients. $OKYO #Clinical #ClinicalTrial #Phase2 #NCP #DED https://lnkd.in/gJbPV_eP
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Various analgesics with different mechanisms of action and different types of analgesia need to be evaluated by corresponding animal models before clinical trials. Click to watch what is nociceptive pain and learn more about Medicilon's nociceptive pain models. https://lnkd.in/g8JK-uk7
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Various analgesics with different mechanisms of action and different types of analgesia need to be evaluated by corresponding animal models before clinical trials. Click to watch what is nociceptive pain and learn more about Medicilon's nociceptive pain models. https://lnkd.in/g8JK-uk7
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Cardiologist, Clinical trialist, Prof and Chair of CV Research at University of New South Wales, South West Sydney, SWSLHD, Ingham Institute, Victor Chang Cardiac Research Institute
Our new article is aviable online. 50 days' free access to everyone before 02/May/2024. Basically, our data from SUCCOUR sub analysis showed that LA stain is not always a panacea. we concluded that "In our 1-year follow-up study, baseline LASr is not independently predictive of CTRCD in a cohort of patients undergoing anthracycline chemotherapy. Our results reiterate the difficulty in identifying a sole baseline parameter to predict CTRCD. Serial imaging parameters remain the best method of identifying CTRCD. Further studies should seek whether a “whole” heart imaging parameter may identify those at highest risk of CTRCD" Nice work Chris Yu! Faraz Pathan, PAALADINESH THAVENDIRANATHAN
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✳️ Translational evaluation of #Gelsectan® effects on #GutBarrier dysfunction & #VisceralPain in animal models & #IrritableBowelSyndrome with #diarrhoea ✅ 7-day oral administration of Gelsectan® prevented the stress-induced rectal hypersensitivity & intestinal hyperpermeability in 🐀 ✅ Gelsectan® restores #IntestinalPermeability in #IBS-D patients 🎯 Gelsectan® may act as a #mucoprotectant with a reinforcing effect on the outer mucus layer of the colon, leading to improvement in intestinal permeability & IBS-D #symptoms 💡 Gelsectan® can be considered as an effective therapy for IBS-D symptoms 👉 Read the full article in UEG Journal: https://bit.ly/3Zful34 #UEGJ
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Are you tired of feeling uncertain when managing anaemia cases? Do you struggle with determining the significance of anaemia, deciding when to investigate, and interpreting additional test results? We understand the challenges you face, and that's why we're excited to introduce the Perfecting Anaemia Workshop. This four-week course is designed to give you a strong foundation in investigating, diagnosing, and treating various forms of anaemia. With our workshop, you'll gain: Practical knowledge and tips for real-world scenarios Confidence in determining significant anaemia levels and when to investigate Understanding of how to monitor IMHA treatment response and manage relapses Skills to safely reduce medication and transfuse patients Strategies for managing cases on a limited budget Our course is different. We'll build your disease knowledge together, focusing on practical applications that translate directly into your daily work. No more theoretical lectures or self-study programs! Join us and become a red blood cell pro! Register now for the Perfecting Anaemia Workshop and start building your confidence in anaemia management. Secure your spot Now!!! https://lnkd.in/e6eEewXQ #anemiaawareness #medicaleducation #veterinarymedicine #smallanimalhealth #animalhealthmatters
Perfecting Anaemia Workshop
nelevet.com
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FLOW CYTOMETRY is crucial in canine research for therapies to treat and save our furry friends and to further innovation in the pet food world! Our comprehensive flow services encompass #immunophenotyping and cellular characterization, diagnostics, and #preclinical studies. Come see how we can help you differentiate your next product with scientific evidence. >> https://lnkd.in/gdGExy86 #flowcytometry #animalnutrition #animalhealth
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This week marked the launch of the EARA Patient Discovery project in Portugal, aimed at providing people living with diabetes with deeper insights into the critical role of animal studies in medical advancements. Hosted with NOVA Medical School - Faculdade de Ciências Médicas and APDP Diabetes, this initiative brought together leading researchers and medical experts in Lisbon to explore the complexities of diabetes research with people living with diabetes. The program included tours of the rodent facility, including participants witnessing both rats and mice in regular experimental procedures, while also taking notice of the huge care with animals. This project connects people with diabetes directly with the researchers working on their condition, bridging the gap between these two groups while conveying the importance of animal research. #PatientEngagement #AnimalResearch #DiabetesResearch #BiomedicalResearch
EARA patient project launches in Portugal
eara.eu
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Linkdein Top Voice/+38K followers/PT OMT ATC MSc PhD Researcher,speaker,innovator,UEFA Pro educator,Chief Scientific Officer Tomako LTD.
Tendinopathy is a common motor system disease that leads to pain and reduced function. Despite its prevalence, our mechanistic understanding is incomplete, leading to limited efficacy of treatment options. Animal models contribute significantly to our understanding of tendinopathy and some therapeutic options. However, the inadequacies of animal models are also evident, largely due to differences in anatomical structure and the complexity of human tendinopathy. Different animal models reproduce different aspects of human tendinopathy and are therefore suitable for different scenarios.
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This is the latest paper from our group, where we discussed the potential benefit of l-carnitine in renal complications in a rat model. https://lnkd.in/gGjze5mX
Protective effects of l-carnitine on isoprenaline -induced heart and kidney dysfunctions: Modulation of inflammation and oxidative stress-related gene expression in rats
cell.com
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92% of vets are interested in our cardiac screening test, rating it a 9 or 10 on a 10-point scale! These are facts revealed a recent market research from Brakke Consulting. Test accuracy over 90% and diagnosing disease early are the most critical feature driving vets' opinion according to the survey. Most vets would recommend our test as part of their annual wellness panel, and for predisposed breed screening for heart disease would even begin between 2-7 years of age. What about you vets from the UK and Europe - Would you adopt our technology in your daily practice? Get in touch to know more: https://lnkd.in/ghypxgwX #cardiacscreening #diagnostics #animalhealth #veterinaryprofessionals #startupstory #Technology #AI #innovation #biotechnology #research #testing #biomarkers #artificialintelligence #precisionmedicine
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