Omar Al Yafei’s Post

View profile for Omar Al Yafei, graphic

Clinical & Deputy chief pharmacist

The SELECT trial reveal that there are many mechanisms of semaglutide that could attribute for cardiovascular and obesity benefit (cardiovascular benefit, liver disease and inflammatory) independent of weight loss, ➡️hence this make it unwise to stop this medication once achieving target weight loss. ➡️Lack of heterogeneity in achieving primary composite endpoints within different subgroups ➡️achieving clinical significance and numerical reduction in all cause mortality. ➡️economical value is challenging ➡️previous supportive evidence for weight loss independent CVS protective actions of the GLP-1 agonist as in HARMONY Outcomes trial for Albiglutide in type 2 DM there was no body weight difference at 28 weeks, yet 22% reduction in MACE, driven by fewer MI events https://lnkd.in/e98ZtQGF

View organization page for American Heart Association, graphic

938,741 followers

SELECT trial results presented at #AHA23 show in adults with overweight or obesity who do not have diabetes, semaglutide reduced the risk of major adverse cardiovascular events by 20%.

  • No alternative text description for this image

To view or add a comment, sign in

Explore topics