Orbito Chemicals’ Post

Accurately measuring particle size for salt-formed active pharmaceutical ingredients (#APIs) is crucial yet challenging for pharmaceutical researchers. Due to their high water solubility, organic solvents must be used instead of water as the dispersion medium in laser diffraction analysis. This requirement introduces the need for a specialized dispersing tool that can handle the complexities associated with organic solvents. 📄Our new application note showcases the Bettersizer 2600 with BT-80N Pro anti-corrosive wet dispersion unit. This system's exceptional accuracy and repeatability ensure precise particle size analysis of salt-formed APIs dispersed in organic solvents, ultimately improving your drug development and manufacturing processes. 👉 Download now for a deeper reading: https://lnkd.in/ddj-KZNM #Bettersize #ParticleAnalysis #drugdevelopment #Pharmaceuticals #drugformulations #drugmanufacturing #solvents #wetdispersion

🔬 Crystallization: The Power of Purity in Industrial Applications 🏭 Did you know that crystallization is a fundamental process across industries, from pharmaceuticals to petrochemicals? By precisely controlling nucleation and crystal growth, engineers ensure the purity and effectiveness of products such as active pharmaceutical ingredients (APIs). This method is vital in optimizing product quality, size distribution, and overall manufacturing efficiency. Understanding crystallization allows us to bring safer, higher-quality products to market while solving complex challenges in production. 🌍 #Crystallization #PharmaceuticalEngineering #ChemicalEngineering #ProcessOptimization

𝗧𝗵𝗲 𝗣𝗼𝘁𝗲𝗻𝘁𝗶𝗮𝗹 𝗳𝗼𝗿 𝗮 𝗕𝗮𝗻 𝗼𝗻 𝗧𝗶𝗢𝟮 (𝗘𝟭𝟳𝟭) 𝘂𝘀𝗲 𝗶𝗻 𝗣𝗵𝗮𝗿𝗺𝗮𝗰𝗲𝘂𝘁𝗶𝗰𝗮𝗹𝘀 - See the latest Technical Newsletter by Fuji Chemical Industries Co., Ltd. Fuji Chemical Industries USA, Inc and read the article ➡️https://lnkd.in/ehMaiXQU #pharmaceutical #excipients #tio2

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How do lyophilized drugs interact with their packaging materials compared to liquid formulations? A study by Steve Zdravkovic, published in the PDA Journal of Pharmaceutical Science and Technology, investigates this question by analyzing how different media—lyophilized and reconstituted drug products, potassium chloride, activated charcoal, and isopropanol/water solutions—extract substances from butyl rubber stoppers. Key Takeaways: 🔄 Polarity Matters: Non-polar media like activated charcoal and concentrated isopropanol/water solutions extracted more hydrophobic oligomers from the rubber stoppers. 💧/ 🧊 Solid vs. Liquid Formulations: Lyophilized drug products were found to leach measurable substances, while reconstituted drugs showed no detectable leachables. 📊 Mathematical Modeling: The extraction power of a lyophilized drug was equivalent to a 50/50 isopropanol/water solution, providing a benchmark for evaluating extraction efficiency. These findings emphasize the importance of understanding interactions between drug formulations and packaging to ensure the safety and efficacy of pharmaceuticals. Check out the full study in the PDA Journal of Pharmaceutical Science and Technology (link in the first comment). #Lyophilization #ExtractablesAndLeachables #RubberOligomers #ButylRubber #RubberStoppers

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💰 Price. 🤩 Quality. 🚚 Delivery time. With Gale Process Solutions (GPS), you get it all. Our customers never have to settle or choose. We will ALWAYS deliver high-quality process equipment with industry-leading delivery times at competitive pricing. #ProcessEquipment #chemical #petrochemical #pharmaceutical #fertilizer