Orthobullets’ Post

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NSAIDs work by inhibiting the cyclooxygenase pathway (COX), which is comprised of the COX-1 and COX-2 pathways. The COX-1 pathway is involved in prostaglandin E2–mediated gastric mucosal protection and thromboxane effects on coagulation, while the COX-2 pathway is mainly involved with the modulation of pain and fever without effect on platelet function. While selective COX-2 inhibitors have a decreased side effect profile, all NSAIDS have the potential to cause renal impairment and their use should be limited in patients with underlying renal disease. Learn more high yield-concepts about Anti-inflammatory Medications on our DAILY Orthobullets podcast. Listen wherever you listen to podcasts! https://bit.ly/3L3GQXA

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