Oryzon Genomics SA’s Post

During our Virtual AML Clinical Day, Moleculin management and industry KOLs discussed the announced positive interim data for Annamycin from our ongoing #AcuteMyeloidLeukemia clinical development program, highlighting the reported higher AML complete remission (CR) rates with additional interim subject data. Watch the replay: https://bit.ly/3JPEfPH

The approach of HMA plus VEN with or without BMT for all patients with AML https://lnkd.in/ehfkAmrb

NBSGW strain provides great potential for the development of humanized models in AML but comes with the pitfall of decreased chemotherapy tolerance. In this y, authors provide a protocol for application of conventional chemotherapy to NBSGW xenografts. Read here 👉 https://bit.ly/3vR7sWS #AML

#ChallengeTheHematologist NGS MRD: The new kid in our system! Now that we are measuring what can be measured, and we land up with new alterations, new scenarios, complex scenarios. Dilemma, discrepancies all creep in My job: Find out, unravel and measure Now the ball is in the clincian’s court Dr. Rahul Bhargava : Lets understand your thoughts: What would you do with this scenario: NPM1 mutated AML (IDH, ASXL1, TET2), post aza ven: FCM MRD neg, NPM1 neg (both pcr and ngs), IDH, ASXL1 and TET2 positive! Thoughts are welcome from everyone: CHIP or disease? Will u treat or leave?

Today, May 7th, is National Fentanyl Awareness Day, a day of action to raise public awareness about lethal, illegally made fentanyl, a dangerous synthetic opioid that is causing people to overdose and die by overdose at alarming rates. In California, over 6,473 people died from a fentanyl-related overdose in 2022. Fentanyl is involved in more deaths of Americans under 50 than any other cause of death, including heart disease, cancer, and all other accidents.   Please help Janus spread the word about the risks of fentanyl and share this information across your networks: 📖 The California Department of Public Health (CDPH) has a webpage where you can learn more about fentanyl and fentanyl test strips. 😨 Fentanyl is up to 50 times stronger than heroin and 100 times stronger than morphine. Even in small doses, it can be deadly. 💰 Fentanyl is cheap, potent, and profitable, so dealers use it to make fake pills. It can also be found in party drugs like cocaine and MDMA. ⚕ If you’re considering using drugs: 1) test your product for fentanyl using a fentanyl test strip, 2) carry naloxone, and 3) know the signs of an overdose. Helpful resources: ☎ If you are struggling with a substance use disorder and want support, call California’s statewide treatment referral line at 800-879-2772 or connect with a harm reduction organization through CDPH’s directory. Janus of Santa Cruz participates in distributing naloxone or fentanyl test strips, through the DHCS Naloxone Distribution Project. I am hopeful that you will join me today to not only celebrate the memory of those that we have lost but also honor them by doing something today to combat this national crisis that we are facing. #decreasestigma #nationalfentanylawarenessday #overdoseprevention https://lnkd.in/g_wKnEUZ https://lnkd.in/gejqRze4

From 2019-2022, xylazine in analyzed forensic reports increased in 47 states. At least 43 states reported xylazine-related deaths; among states with data available, the highest reported xylazine-involved death rates were in VT and CT in 2022. https://ja.ma/3NQUJtk

The recent completion of the KOMET-001 trial enrollment is not only a major milestone for the many clinical investigators who work tirelessly for their patients, but is also an important step in advancing AML treatment. Early data indicate that this milestone brings us closer to realizing the potential of ziftomenib and better understanding NPM1-m AML. Discover the latest on KOMET-001 and actively recruiting KOMET trials in AML: https://bit.ly/3xL3bWd

Register now! In this webinar, Dr. Nathan Punwani will discuss the development of secondary AML from high-risk MDS, treatment options, and the quality of life impact for patients. You can submit questions in advance by emailing help@aamds.org. https://cvent.me/v0VlQw #MDS #AML #acuteleukemia

Every year, it is estimated that over 1 million people die due to treatment from a #counterfeit drug. #Substandard and #falsified medicines is one of the fastest-growing criminal enterprises in the world and poses significant, and potentially fatal, #patientsafety threats. As we celebrate #WorldPatientSafetyDay, learn more in FTFA report here: https://bit.ly/3LIKh5I  #FighttheFakes #fakemeds

The global drug problem requires a multifaceted approach rooted in science, evidence-based interventions, and human rights. Early warning system helps preventing the crisis before it happens: The UNODC Early Warning Advisory (EWA) plays a crucial role in monitoring, analyzing, and reporting emerging trends in New Psychoactive Substances (#NPS). This initiative supports countries in addressing the persistent challenges posed by illicit trafficking of NPS, ensuring they stay informed and prepared to respond to and prevent these evolving threats. To find out more 🔗: https://lnkd.in/dRDV5iyv Join us in marking #WorldDrugDay and reinforcing our commitment to having a world safer from drugs.