OUP Academic’s Post

📰 Did you know we have a newsletter packed with our latest news, blogs, and case studies? 🔍 You can also catch up on all our past issues 🚀 Stay in the loop and subscribe now! 👉 https://lnkd.in/eqj4Qumc Recent highlights include: 📌 Modelling crystallography with AlphaFold 📌 Using mass spectrometry to analyse covalent compound binding 📌 Production of Active Cereblon and Analysis by SPR

Studying protein-protein interactions can be challenging, but advances in technology are making it easier. Techniques such as surface plasmon resonance, proximity ligation assays, and bioluminescence-based detection provide researchers with more efficient and sensitive ways to investigate molecular interactions. Explore our latest editorial that discusses how these methods enable real-time analysis, precise localization, and simplified workflows without extensive training or complex equipment. https://lnkd.in/gy_m326w

Our analysis of tandem RRMs offers fresh insights into studying the orientation between multiple-domain proteins, highlighting the importance of the synergy of experimental data with AlphaFold2 predicted structures. Check out the link below for more details! Link to paper: https://lnkd.in/dg5GzjQE

Today and tomorrow in Rotterdam: SelectBIO Lab-on-a-Chip and Microfluidics Europe 2024   Our colleague Dmytro Pastukh will also be there. He will present the topic "Microfluidic-based, isothermalamplification and quantification of circulating cell-free DNA" at the poster session there.   He will present the development of a point-of-care (PoC) analysis system based on a microfluidic cartridge to enable rapid on-site quantification of cfDNA concentrations in intensive care units and emergency rooms. Therefore, recombinase polymerase amplification is a promising approach, as this technique is characterized by robustness against inhibitors and enables analysis in whole blood samples without DNA purification steps.   More information about the conference 👉 https://lnkd.in/ewY8RREe   #Fraunhofer | #research | #microfluidics | #PointOfCare | #LabOnAChip | Fraunhofer IMM

To remain competitive against other technologies, mass spectrometry (MS) needs to rise to the challenge of unprecedented throughput with very deep analyses of very complex samples. With analysis time reduced to several minutes by fast liquid separations, confident identification and quantitation over many orders of dynamic range still requires a generational leap in the sequencing performance of MS. The Thermo Scientific™ Astral™ analyzer is a novel class of high-resolution accurate-mass analyzer that compliments the Thermo Scientific™ Orbitrap™ analyzer to provide high speed and sensitivity measurements.   This webinar will explore the underlying technology of the Thermo Scientific™ Orbitrap™ Astral™ mass spectrometer and its’ application to biomedical research. Rethink what is possible with a mass spectrometer including the analysis of 300 proteomics samples per day, measuring 5,000 proteins from a true single-cell, and collecting fragmentation data on over 90% of compounds in metabolomics experiments. Register here: https://lnkd.in/eGRfDhWE #thermofisherscientific #massspectrometry #orbitrap #orbitrapastral

Check out the webinar on Thursday to hear how we do high-throughput expression and characterisation of proteins

Structure-based prediction and characterization of photo-crosslinking in native protein–RNA complexes. This research suggests protein-RNA photo-crosslinking is highly selective in the cellular environment, which can guide data interpretation and further technology development for UV-crosslinking-based assays. https://hubs.ly/Q02pRwz40

The timsTOF Ultra 2 is here to redefine the boundaries of mass spectrometry. Designed for the most demanding research environments, this state-of-the-art instrument is set to revolutionize your lab’s capabilities. Let’s dive into what makes the timsTOF Ultra 2 a game-changer in the world of proteomics. Key Features and Benefits: ICC 2.0 (Ion Charge Control): Benefit: ICC 2.0 ensures optimal ion control, enhancing the precision and accuracy of your measurements. This feature is crucial for handling a broad range of sample loads, from low picograms to micrograms, making your experiments more reliable and reproducible. Upgradeability: Benefit: The timsTOF Ultra 2 is designed with future advancements in mind. Its upgradable platform allows you to seamlessly integrate the latest technological innovations, ensuring your research stays at the cutting edge without the need for a complete system overhaul. Unmatched Sensitivity: Benefit: With the ability to detect up to 50% more protein groups and 100% more peptides at 25 pg sample loads, the timsTOF Ultra 2 offers unparalleled sensitivity. This capability is essential for deep proteomic profiling, enabling groundbreaking discoveries even from the smallest samples. Bruker ProteoScape with Spectronaut 19: Benefit: The integration of Bruker ProteoScape with Spectronaut 19, specifically trained on timsTOF data, enhances the depth and accuracy of protein quantitation. This powerful combination allows for more comprehensive and precise proteomic analyses, pushing the boundaries of what’s possible in your research. Ready to elevate your research to new heights? Connect with us to explore how the timsTOF Ultra 2 can transform your proteomics studies. Let’s push the frontiers of science together!” Learn more about the timsTOF Ultra 2: https://lnkd.in/eYpXVHDA #massspectrometry #proteomics #timsTOF

𝐃𝐫𝐮𝐠-𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲 𝐦𝐨𝐝𝐚𝐥𝐢𝐭𝐢𝐞𝐬 𝐚𝐫𝐞 𝐫𝐚𝐩𝐢𝐝𝐥𝐲 𝐞𝐯𝐨𝐥𝐯𝐢𝐧𝐠 𝐩𝐚𝐬𝐭 𝐭𝐫𝐚𝐝𝐢𝐭𝐢𝐨𝐧𝐚𝐥 𝐬𝐦𝐚𝐥𝐥-𝐦𝐨𝐥𝐞𝐜𝐮𝐥𝐞 𝐢𝐧𝐡𝐢𝐛𝐢𝐭𝐢𝐨𝐧. 𝐓𝐨 𝐬𝐭𝐚𝐲 𝐜𝐨𝐦𝐩𝐞𝐭𝐢𝐭𝐢𝐯𝐞, 𝐝𝐫𝐮𝐠 𝐡𝐮𝐧𝐭𝐞𝐫𝐬 𝐰𝐢𝐥𝐥 𝐢𝐧𝐜𝐫𝐞𝐚𝐬𝐢𝐧𝐠𝐥𝐲 𝐧𝐞𝐞𝐝 𝐜𝐨𝐦𝐩𝐮𝐭𝐚𝐭𝐢𝐨𝐧 𝐭𝐨 𝐮𝐭𝐢𝐥𝐢𝐳𝐞 𝐭𝐡𝐞𝐦. One of these basic, but critical, methods is molecular dynamics (MD). 𝑴𝑫 𝒔𝒊𝒎𝒖𝒍𝒂𝒕𝒊𝒐𝒏𝒔 𝒐𝒇𝒕𝒆𝒏 𝒇𝒂𝒄𝒆 𝒔𝒊𝒈𝒏𝒊𝒇𝒊𝒄𝒂𝒏𝒕 𝒄𝒐𝒎𝒑𝒖𝒕𝒂𝒕𝒊𝒐𝒏𝒂𝒍 𝒄𝒉𝒂𝒍𝒍𝒆𝒏𝒈𝒆𝒔 when attempting to replicate the biological timescales relevant for ligand binding and unbinding processes. One of our approaches mitigates these limitations by utilizing the latest developments in weighted ensemble (WE) algorithms. These methods bypass the need for weeks-long brute-force simulations and/or biasing forces, 𝒆𝒏𝒂𝒃𝒍𝒊𝒏𝒈 𝒔𝒊𝒎𝒖𝒍𝒂𝒕𝒊𝒐𝒏𝒔 𝒕𝒐 𝒓𝒆𝒂𝒄𝒉 𝒖𝒑 𝒕𝒐 𝒕𝒉𝒆 𝒎𝒊𝒏𝒖𝒕𝒆𝒔 𝒕𝒊𝒎𝒆𝒔𝒄𝒂𝒍𝒆 on standard hardware configurations without sacrificing accuracy. Our efficient implementation in wepy (for which we are the original authors of) and OpenMM is especially suited for distributed cloud-based environments that can take advantage of cheap spot instances, removing the need for provisioning and managing large and expensive MPI clusters commonly needed with other methods. By integrating experimental data, such as Hydrogen-Deuterium Exchange (HDX), we can unlock deep understanding of complex processes; such as conformational changes and protein-ligand interactions. This capability is becoming critical for new generations of drug treatment modalities, like 𝐭𝐚𝐫𝐠𝐞𝐭𝐞𝐝 𝐩𝐫𝐨𝐭𝐞𝐢𝐧 𝐝𝐞𝐠𝐫𝐚𝐝𝐚𝐭𝐢𝐨𝐧 (𝐓𝐏𝐃) and 𝐚𝐥𝐥𝐨𝐬𝐭𝐞𝐫𝐲. For a comprehensive insight into how cloud-native weighted ensemble simulations can transform your drug design and discovery processes, we invite you to explore our dedicated page. Please visit: https://lnkd.in/eG429k9j #moleculardynamics #drugdiscovery #tpd #allostery #computationalchemistry #cloudcomputing

Unveiling the game-changer in proteomics: the NEW SCIEX ZenoTOF 7600+ system! 👉👉👉 https://sciex.li/86f4sq We're thrilled to introduce the newest powerhouse in our ZenoTOF line—the ZenoTOF 7600+ system. This revolutionary technology will redefine your proteomics research with its unparalleled ZT Scan DIA capabilities. Why make the ZenoTOF 7600+ system your go-to system? ✅ Unmatched detection: Identify up to 125% more quantifiable protein groups at sub-nanogram levels. ✅ Enhanced analytical power: Leverage Electron Activated Dissociation (EAD) for expanded analytical capabilities. ✅ Blazing speed: Benefit from scanning speeds up to 640 Hz, perfect for large quantitation panels. Elevate your research and pioneer new advancements in precision medicine with the SCIEX ZenoTOF 7600+ system. Ready to revolutionize your workflow? Learn more about the ZenoTOF 7600+ system here: https://sciex.li/86f4sq #Proteomics #ZenoTOF7600Plus #ZTScanDIA #PrecisionMedicine #TranslationalResearch