Ozette’s Post

Expansive Development of Transcriptomic Clocks for Aging and Mortality This open access paper represents a great deal of scientific work. Researchers analyzed transcriptomics from all of the successful Interventions Testing Program

We are honored to introduce Prof. Emmanuel MARGEAT as an invited speaker at this year's Single Molecule Workshop. Prof. Margeat will talk about "Dissecting the structural dynamics of a GPCR using smFRET". He is Director of the Centre de Biologie Structurale, Montpellier, France. His lab advances single molecule biophysical methods and applies them to the study of macromolecular complexes at biological membranes. These are involved in membrane organization and remodeling, mechanical transduction and chemical signal transduction. Don't miss the opportunity to learn from him, ask your questions, and discuss your research challenges! October 8 - 10, 2024 Berlin, Germany ➡️Present your own results and submit your abstract by July 24: https://lnkd.in/dpXy-4A ➡️Register by September 6: https://lnkd.in/dpXy-4A #smFRET #molecules #spectroscopy #microscopy #fluorescence #materialsscience #lifescience

📢 Explore highly cited papers from 2022–2023 in the "Bioinformatics and Systems Biology" section of Biomolecules! Dive into groundbreaking research on PyMOL, AlphaFold, miRNA-Disease Associations, and more. Check them out: 1. “Boosting the Full Potential of PyMOL with Structural Biology Plugins” 2. “Calcium Overload and Mitochondrial Metabolism” 3. “Benchmarking the Accuracy of AlphaFold 2 in Loop Structure Prediction” …and more! 🔗 Full list: https://brnw.ch/21wLVCu

What Defines a Cell Type? The Complexity of Categorizing Cells Tiago Lubiana just earned his PhD! In his thesis, he tackled a question that sounds simple but is actually incredibly complex: What defines a cell type? Estimates for the number of cell types vary widely, from around 200 to over 6,000, depending on the criteria used. Take human T cells, for example. They express CD3 proteins, and if they also express CD4, we call them CD4 T cells. Add a few more markers, like CD25 and FOXP3, and those CD4 T cells become classified as regulatory T cells (Tregs). But now, with single-cell technologies, we can measure hundreds of potential markers, creating even more subcategories. So, where do we draw the line? How do we decide when one cell is distinct enough to be considered a different "type"? Just like defining species, figuring out what makes a "cell type" will eventually need a consensus on clear criteria from the scientific community. And this is especially important in single-cell analysis, which relies on these definitions to map out the diversity of cells in complex tissues and systems. And of course, a big thanks goes to the thesis committee! Yesid Cuesta Astroz, Helena Brentani e Jose Eduardo Santarem Segundo.

For those interested in non-destructive analyses for measuring/observing function. Live cell imaging like those from EMSL’s NanoLive and Lattice Light Sheet microscope offers a fantastic means to overserve phenotypic changes seen in morphology and interactions dynamically to better understand and predict function when perturbed…

https://lnkd.in/gw6_RXvV New report: Current trends and research topics regarding organoids: A bibliometric analysis of global research from 2000 to 2023.

In the shared pursuit of science, to say it “takes a village” would be an understatement. Researchers all over the world 🌏 are taking strides daily to pursue the next big innovation to advance personalized medicine. What drives your pursuit of innovation? Comment below. ⬇️ Looking for more ways to help advance your discoveries in science and set yourself up for future success? Check out the latest tools across molecular biology research applications: https://lnkd.in/gqXFyn2c

𝗡𝗲𝘄 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗼𝗺𝗶𝗰𝘀 𝗪𝗲𝗯𝗶𝗻𝗮𝗿 Dive into the structural characterization and identification of new psychoactive substances and their metabolites using electron-activated dissociation (EAD). EAD offers enhanced fragmentation data compared to collision-induced dissociation (CID), significantly boosting confidence in the structural elucidation of these substances. Join Peng Che, PhD candidate at Vrije Universiteit Amsterdam, for an in-depth look at how EAD can revolutionize metabolite identification (Met-ID) workflows. 🔗: 𝗪𝗮𝘁𝗰𝗵 𝗻𝗼𝘄 𝗶𝗻 𝗼𝘂𝗿 𝗰𝗼𝗻𝘁𝗲𝗻𝘁 𝗽𝗮𝗰𝗸: https://bit.ly/3UT3W74

The April issue of Molecular Imaging & Biology (MIB) is now available! Packed with 19 articles covering a diverse range of topics that are sure to captivate your scientific curiosity. For a glimpse of what's in store, check out the table of contents: https://ow.ly/2WIA50R4j8i WMIS members can access full articles through the member portal: https://lnkd.in/d9JAixG Dive into the latest research, stay informed, and expand your knowledge in molecular imaging and biology. Happy reading! #MolecularImagingandBiology #MIB #SpringerNature #WMIS

A materials scientist at the University of Groningen, Zernike Institute for Advanced Materials who specializes in solid-state NMR has made an important contribution to a paper on the root cause of Barth syndrome, a deadly genetic disease which ruins the mitochondria. I wrote this report on the work of Patrick van der Wel and colleagues for the Faculty of Science and Engineering - University of Groningen https://lnkd.in/e3Efi3Yd (English and Nederlands) The research also points the way to a possible cure. #barthsyndrome #mitochondrialdisease