Paralab SA’s Post

Organic electrochemistry is revolutionary in the #pharmaceutical, crop protection and fine #chemical industries since electrons can be used to perform reactions in place of chemical reagents. Reaping benefits such as: ✔️ More eco-friendly manufacturing of drugs & other substances ✔️ More sustainable production of essential #medicines ✔️ Fewer production costs However, there are considerable challenges that hinder its widespread adoption in these industries. Dr. Jason Williams, principal scientist at RCPE - Research Center Pharmaceutical Engineering GmbH, is here 👇 to share how powerful s-X-AIPI solutions can enable the routine use of organic #electrochemistry in the manufacturing sector. https://lnkd.in/dEemP-iN Elisabeth Fink Michael Pölzl

Applying #AI to the process industry has many benefits. In the s-X-AIPI project, RCPE - Research Center Pharmaceutical Engineering GmbH is exploring - the use of optical coherence tomography for electrode monitoring - sensor fusion to enhance predictive models - smart user interfaces for process monitoring Curious? Get in touch to find out more! #OCT #sensorfusion #processoptimization #greenchemistry

Advances in analytical instrumentation like Chromatography and Mass Spectrometry used in Pharmaceutical, Biotechnology, and Academic research have increased the sensitivity of detection for trace-level organics. This can involve sensitivities in the sub-ppb (part per billion) or even ppt (part per trillion) range. Achieving and maintaining the accuracy of the results is highly dependent on the purity of the water used in such applications. This was the theme of our recent seminar – Precision H2O, where we had the honor to host 100+ QA/QC specialists and application experts from the pharmaceutical companies in Vizag. Our presenters put forward some very insightful sessions on the best practices, regulatory requirements, and innovative solutions to meet the stringent industry standards. The engagement and expertise of all the participants made this seminar truly outstanding. Looking forward to many more such events as we continue our journey towards innovation and excellence in the industry! #PrecisionH2O #seminarseries #Vizag #chromatography #waterpurity #wateranalysis #innovation #pharma #research #laboratorysolutions #thermoscientific

#CMAC is excited to share our latest published research, which addresses a critical challenge in pharmaceutical manufacturing: the resource-intensive process of developing crystallisation methods for commercial production. Our study introduces an extension and application of a model-driven workflow that reduces the material and resource demands traditionally required for crystallisation process development. By systematically collecting and evaluating thermodynamic and kinetic data, we've demonstrated that it’s possible to effectively translate small-scale experimental results to larger scales. Key highlights: 🔷 Achieved process development in just 8 weeks. 🔷 Expanded the workflow to a 50x scale-up, integrating cooling, antisolvent, and seeded modes of crystallisation. 🔷 Optimised the recrystallisation for an industry-relevant API, achieving precise control over product quality. 🔷 Significantly reduced material usage while meeting target specifications for oral bioavailability and uniformity. This approach not only enhances efficiency but also opens new possibilities for sustainable pharmaceutical manufacturing. We are delighted about the impact this could have on future drug development! 🔗 Read the paper: https://lnkd.in/e4GFZvfU #PharmaceuticalInnovation #Crystallisation #ProcessDevelopment #Sustainability #DrugManufacturing #ResearchAndDevelopment  Thomas Pickles Václav Svoboda Ivan Marziano FRSC Cameron Brown Alastair Florence

Join Us for an Insightful Presentation by Eric Hill at American Association of Pharmaceutical Scientists (AAPS) | @aapscomms! 🌟  🗓 Date: Tuesday, October 22, 2024  🕘 Time: 9:00 AM – 10:00 AM MT  📍 Location: 360 Stage #3, Exhibit Hall     We're excited to announce that Eric Hill, Chief Scientific Officer at BA Sciences, will be presenting on the Characterization of Single Use System Components for Extractables & Leachables.     🔍 What’s It About?  Single Use Systems (SUS) are revolutionizing biomanufacturing, but they also bring unique challenges regarding extractables and leachables (E&L). Discover how to navigate these challenges while leveraging the advantages of SUS, including ease of use, quick change-out capability, and flexibility.    💡 Learning Objectives:   Gain fundamental insights into E&L testing for single use systems.  Understand the BPOG Standardized Extractables Testing Protocol and the proposed USP <665> chapter.  Explore a practical guide map for the successful selection, qualification, and implementation of SUS components from an E&L perspective.    Be sure to mark your calendars and join us! #AAPS2024 #ExtractablesAndLeachables #Biomanufacturing #SingleUseSystems #Pharmaceuticals #Bioprocessing    👉 Tag someone who should attend!

Advanced particle analysis revolutionises pharma development The CCDC - The Cambridge Crystallographic Data Centre) developed a suite of advanced informatics tools that enhance researchers' understanding of particle behaviour and surface properties in pharmaceutical manufacturing. These tools improve product formulation efficiency and reduce costs, showing significant benefits in various research studies. These innovations support formulators and particle engineers to make better informed decisions, advancing #pharmaceutical and fine #ChemicalManufacturing. Developed in collaboration with industry leaders like AstraZeneca and Pfizer, CSD-Particle tools promote a ‘digital first’ approach in drug development, minimising non-viable formulations and anticipating bottlenecks early on. https://lnkd.in/eTwD546m

UV-Visible Spectroscopy is an analytical technique used to measure the absorption of ultraviolet (UV) and visible light by a chemical substance. Widely used in chemical, pharmaceutical, and biological research to analyze compounds, determine concentrations, and study molecular structures based on their absorption of UV and visible light. #pharmaceutical #analysis #research #concentration #chemical

What´s today? Today and tomorrow (May 2 -3, 2024) the “6th Flow Chemistry and Continuous Processing Conference” organized by Scientific Update Ltd takes place in Boston USA. Our contribution on site is the "Semi-Batch and Scalable Continuous Synthesis of Grignard Reagents" with our recently graduated colleague Eva Deitmann.   About 10 percent of the 50 most important active pharmaceutical ingredients have one or more Grignard reactions in their synthesis pathway. Eva Deitmann will focus on industrially relevant research in the field of reactive intermediates and present our scalable, flexible and patented technology in Boston, which uses a permanent magnesium excess and microstructured reactors to synthesize the reactive intermediates reliably and in better quality.   Information about the conference 👉 https://lnkd.in/ePspr8GZ   Information about our industrial relevant research and development in the reactive intermediates 👉 https://lnkd.in/eFwkS6-7   #flowchemistry | #chemistry | #Fraunhofer | #research | #reactiveintermediates | #synthesis | #organicchemistry | #organometallics

The adoption of mathematical modeling to facilitate the optimization and control of (bio)pharmaceutical manufacturing processes is an important trend that is having significant dividends and will help to improve the quality of and access to medicines around the world. In this review, Francesco Destro, Prakitr Srisuma, and I (under the mentorship of Prof Richard D. Braatz) review recent advances in model-based optimization and control of various pharmaceutical processes. We also cover developments in ancillary areas such as open-source software tools and sensors. Thanks for the delightful collaboration, looking forward to the next paper! You can access this paper for free with the link below! https://lnkd.in/ecEvcD2D

AI's disruptive surge: the end of trial-and-error in #pharmamanufacturing? Researchers at the University of Cambridge and Pfizer have collaborated to develop an AI-powered platform revolutionizing pharmaceutical design and manufacturing. Their innovative approach to high-throughput experimentation (HTE) utilizes #machinelearning to predict chemical reactions virtually, eliminating the need for trial-and-error experiments. The system, known as the 'reactome,' is a database of reaction pathways derived from extensive pharmaceutically relevant data, enabling faster drug design and more efficient late-stage functionalization reactions. This breakthrough could reshape organic chemistry, accelerate drug development, and enhance our understanding of chemical processes. #pharmainnovation #digitalpharma #pharmatech