Patheous Health’s Post

This retrospective study at the National Cardiovascular Center Harapan Kita analyzed 1056 on-pump CABG procedures from January 2019 to December 2022, finding that high preoperative systemic immune-inflammation index (SII) values were significantly associated with poor perioperative outcomes. Patients with an SII value ≥528.715 #Morbidity #Mortality #OnPumpCoronaryArteryBypassGraft #SystemicImmuneInflammationIndex #SystemicInflammation

Take the JAMA Clinical Challenge A man in his 70s presented with 2 progressively enlarging, painless nodular lesions on the forehead & right cheek, initially observed as erythematous nodules 3 months prior. He noted a gradual increase in size with subsequent central ulceration. Patient also noted the development of blackish crusting. The absence of fever, pain, or discharge from the lesions and immunocompromised status due to kidney transplant in 2004 were notable. What is your diagnosis? Comment your answer below. A. Cutaneous histoplasmosis B. Cutaneous blastomycosis C. Rhinosporodiosis D. Cryptococcosis Friday at 12 pm ET we’ll post the answer.

IgG4-Related Disease is a rare fibro-inflammatory condition with 5 to 10 affected subjects in 100.000 people prevalence that can involve multiple organs at the same time and even lead to organ failure and chronic morbidities. Ospedale San Raffaele is leading the example in how to treat it, with its commitment to do more research and fight it with the IgG4-RD Clinic, a dedicated space with long-experienced immunologists and rheumatologists. The Clinic's team was actually the first to describe IgG4-RD and has so far published more than 100 scientific works. Since IgG4-RD can impact several organs at the same time, the Clinic follows a multidisciplinary approach to grant rant a 360°care to each patient. Being a national and international landmark for IgG4-RD, the Clinic offers professionals the chance to be part of research projects, clinical trials, even benefit from up-to-date off-label treatments, and discuss social and psychological aspects of IgG4-RD. #GruppoSanDonato #GSDHealthMag #ScienceBased #RareDisease

Atrial fibrillation is a condition characterized by irregular heartbeats that can be treated with a procedure called catheter resection, which is a treatment where a catheter is used to remove or "burn" small areas of the heart that cause rhythm problems. Previously, studies on how patient sex affects treatment outcomes for this issue have been inconsistent. However, a new international study, led by the Icahn School of Medicine at Mount Sinai, examined 1,568 patients, both men and women, who underwent a new type of resection called "pulsed-field resection". The results showed that this method was successful in both men and women, with similar success rates (around 76-79%), and it was shown to be safe and effective. This innovative approach offers improved results compared to the traditional methods used previously.   Motivated by these advances, at Cinfa we are also involved in pharmacological treatments which are highly significant in the prevention or treatment of cardiovascular diseases. “At Cinfa we have wanted to place more emphasis and become more involved in research on cardiovascular diseases that will allow us to benefit patients suffering from these pathologies.” reports Alicia Lopez de Ocariz, Chief Scientific Officer at Cinfa Group. https://lnkd.in/dGzdew8x #cardiovasculardiseases #atrialfibrilliation #healthcaremiddleeast

New advancements at Universitätsklinikum Erlangen bring new possibilities for treating severe lupus nephritis, a critical kidney complication of systemic lupus erythematosus (SLE). A recent case study details the recovery of a 15-year-old patient who, after receiving CD19-targeted CAR T-cell therapy, was freed from hemodialysis and showed significant improvements in kidney function and overall health. This innovative therapy, previously successful in adult patients with refractory SLE, now demonstrates its potential in adolescents. Published in a recent medical journal, this represents a significant step forward in the treatment of autoimmune diseases, showcasing the transformative potential of CAR T-cell therapy for severe lupus nephritis. #AutoimmuneDisease #LupusNephritis #CARTherapy #MedicalResearch #Innovation #UniversityHospitalErlangen

In our recent study, we investigated the risk of adjacent-level fractures following interventions for osteoporotic vertebral compression fractures (VCFs). Through randomized controlled trials (RCTs), we aimed to compare the outcomes of vertebroplasty and kyphoplasty against the natural progression of the disease. Key Findings: - RCTs were conducted to evaluate the risk of adjacent-level fractures post-intervention. - Results indicated no significant difference in the incidence of adjacent compression fractures between patients who underwent vertebroplasty or kyphoplasty and those who followed the natural disease course. - This provides robust evidence that interventional treatments such as vertebroplasty and kyphoplasty do not elevate the risk of subsequent adjacent fractures. These findings are crucial for informing clinical decisions and reassuring both practitioners and patients regarding the safety of these common interventional treatments for VCFs. Our study underscores that opting for vertebroplasty or kyphoplasty does not compromise the structural integrity of adjacent vertebrae. • The link to our study: https://lnkd.in/d4qr-uFk #Osteoporosis #VertebralFractures #RCT #Vertebroplasty #Kyphoplasty #SpineHealth #ClinicalResearch

Vein ablation is a minimally invasive procedure that uses heat to close off abnormal veins and redirect blood flow to healthy ones. Varicose veins are swollen, twisted veins that can cause pain, itching, and discomfort. They are often caused by weak or damaged valves in the veins. Champion Heart and Vascular Center is a leading provider of cardiovascular care in North Carolina, with locations in Durham, Henderson, and Raleigh. They offer a range of services, including vein ablation, to treat various vascular conditions and improve the quality of life of their patients. I hope this image meets your needs. If you have any feedback or suggestions, please let me know. 😊 : [Vein Ablation | Johns Hopkins Medicine](https://lnkd.in/ewrtWXYE) : [Varicose veins - Symptoms and causes - Mayo Clinic](https://lnkd.in/dgEKzNUE) : [Champion Heart and Vascular Center: Home](https://lnkd.in/e8bhrBpZ)

In a recent randomized trial published in JAMA, researchers explored the potential benefits of acetaminophen in sepsis management. The study involved 447 patients with sepsis accompanied by respiratory or circulatory organ failure and compared the outcomes of patients receiving acetaminophen (1 gram every six hours for five days) to those receiving a placebo. The findings revealed no significant difference in the number of days patients were alive and free of organ support between the acetaminophen and placebo groups. Interestingly, the incidence of acute respiratory distress syndrome (ARDS) was notably lower in the acetaminophen group (2% compared to 9%). These preliminary results are promising; however, further research is required to establish the routine use of acetaminophen in patients with sepsis and organ dysfunction. #SepsisResearch #CriticalCare #MedicalResearch #Acetaminophen #ClinicalTrials #JAMAPublication #OrganFailure

Just as AI and humans in combination generate the strongest data, so with imaging and bloods together.

Dr. Hassan Alnuaimat, Staff Physician, Pulmonology, Respiratory Institute, alongside Dr. Manyoo Agarwal, Staff Physician, Cardiovascular Medicine, Heart, Vascular & Thoracic Institute at #ClevelandClinicAbuDhabi, take a deep dive into the topic of pulmonary hypertension. In this episode, they discuss how the rare and challenging disease to diagnose, can be effectively addressed through our multidisciplinary approach, significantly improving patients' chances of detection and successful treatment. Watch to learn more. https://lnkd.in/dm7CvmRe