Researchers from PSI Paul Scherrer Institut, ETH Zürich and University of Geneva have revealed how drug molecules bind in a type of channel that connects neighbouring cells, changing intercellular communication. The team studied channels made from proteins called connexins, which allow small molecules and ions to be exchanged between adjacent cells. Dysfunctions of these channels has been linked to many different diseases including cardiac #arrhythmias, #epilepsy and #cancer. Using cryo-electron microscopy, the team revealed how the antimalarial drug, mefloquine, binds in the channels. As well as giving a possible explanation for well-known side effects of mefloquine, the research gives new understanding of how drug molecules act on connexins channels in general, aiding the development of connexin-targeting drugs. Full Story: https://lnkd.in/dKS7T6qh CC: Volodymyr Korkhov Image: Laura Canil #ResearchAtPSI #HealthInnovation #Neuroscience #DrugDiscovery #ResearchMatters
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Very happy to see this illustration out! Volodymyr Korkhov contacted me for preparing an image to represent #IntercellularCommunication. After brainstorming several ideas we finally decided to show the communication as bright particles flowing from one cell to the other, "activating" the latter. Love the final result! Check out this post from PSI Paul Scherrer Institut to read more about the latest findings! #SciArt #SciComm #StructuralBiology
Researchers from PSI Paul Scherrer Institut, ETH Zürich and University of Geneva have revealed how drug molecules bind in a type of channel that connects neighbouring cells, changing intercellular communication. The team studied channels made from proteins called connexins, which allow small molecules and ions to be exchanged between adjacent cells. Dysfunctions of these channels has been linked to many different diseases including cardiac #arrhythmias, #epilepsy and #cancer. Using cryo-electron microscopy, the team revealed how the antimalarial drug, mefloquine, binds in the channels. As well as giving a possible explanation for well-known side effects of mefloquine, the research gives new understanding of how drug molecules act on connexins channels in general, aiding the development of connexin-targeting drugs. Full Story: https://lnkd.in/dKS7T6qh CC: Volodymyr Korkhov Image: Laura Canil #ResearchAtPSI #HealthInnovation #Neuroscience #DrugDiscovery #ResearchMatters
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Head of Scientific & Technical Services IDIBELL: "What do you need? We help you!"
IDIBELL SCTs AT THE CataloniaBioHT CONNECTION DAY. We are very excited to participate in the CataloniaBio & HealthTech Connection Day to present our IDIBELL Scientific and Technical Services to the Pharma sector, with the motto: “Facing problems? We have solutions. Reach out!”. Particularly to showcase our new equipment: Simoa (Quanterix) ultra-sensitive biomarker detector which allows for picogram-level detection as opposed to nanograms (in blood samples instead of cerebrospinal fluid for example) and CosMx (Nanostring, presumably, still in a public tender process), enabling the quantification and histological localization of thousands of transcriptomic and proteomic markers at single-cell resolution. #CataloniaBioHT #IDIBELL #SCT #CosMx #Simoa #Nanostring #Quanterix #Neurosciences #Cancer #CERCA #CERCAGinys
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Unlocking Clues to Alzheimer's: Early Detection Hope! Normally, proteins bind phosphate groups, aiding cell functions. But in Alzheimers’s disease (AD), over-phosphorylation leads to loss of binding ability with Tubulin, contributing to neurodegenerative processes. Recent studies have shown that the plasma of AD patients contains a large amount of p-Tau (Thr181) and p-Tau (Thr217) compared with normal people. As p-Tau (Thr181) and p-Tau (Thr217) are elevated in the preclinical to clinical disease stages of this disease, and their cost of measuring their levels are low, they can be used as early clinical detection biomarkers of AD. Learn more about our Recombinant Tau (Phospho-Thr181) antibody: https://lnkd.in/e6uNV-9P and Recombinant Tau (Phospho-Thr217) antibody: https://lnkd.in/eZfEwKav Feel free to contact us if you have any questions. #imtecdiagnostics #neuroscience #alzheimersresearch
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Unlocking Clues to Alzheimer's: Early Detection Hope! Normally, proteins bind phosphate groups, aiding cell functions. But in Alzheimers’s disease (AD), over-phosphorylation leads to loss of binding ability with Tubulin, contributing to neurodegenerative processes. Recent studies have shown that the plasma of AD patients contains a large amount of p-Tau (Thr181) and p-Tau (Thr217) compared with normal people. As p-Tau (Thr181) and p-Tau (Thr217) are elevated in the preclinical to clinical disease stages of this disease, and their cost of measuring their levels are low, they can be used as early clinical detection biomarkers of AD. Learn more about our Recombinant Tau (Phospho-Thr181) antibody: https://lnkd.in/e6uNV-9P and Recombinant Tau (Phospho-Thr217) antibody: https://lnkd.in/eZfEwKav Feel free to contact us if you have any questions. #itkdiagnostics #neuroscience #alzheimersresearch
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#mustread 🧠 The oncogenic role of CELF2 in promoting the stemness and proliferation of glioblastoma cells. https://lnkd.in/dfg_zv9Q Using our anti-CELF2 Triple A polyclonal antibody, this study explores the expression profile and mode of action of CELF2 (an RNA-binding protein) in a collection of human glioblastoma samples and patient-derived glioma stem cells. 👉 The results reveal high levels of CELF2 expression in proliferating the OLIG2-positive glioblastoma cells and a lack of expression in other tumor cells, illustrating the complexity of intra-tumor heterogeneity in glioblastoma, and overall supporting the oncogenic role for CELF2 in promoting the stemness and proliferation of glioblastoma cells. 🔬Anti-CELF2 polyclonal HPA035813 https://lnkd.in/dec7kffq #cancerresearch #neuroscience #brainresearch #glioma #atlasantibodies #primaryantibodies
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InterScale Research Fellow | Research Specialist | Uplifting Futures | Advocate for CAMH & Environmental Friendly Policies
If you've ever doubted whether glucose is harmful for kids, this study should clear your doubts. Here's what happened: A researcher took immature brain cancer cells and exposed them to high levels of glucose. He found that the cells exposed to high glucose had reduced viability compared to those exposed to low glucose levels. GLUCOSE REDUCED THE VIABILITY OF CANCER CELLS! Let that sink in. If something can weaken a cancer cell, can you imagine how harmful it might be to your normal, growing cells? Furthermore, the study revealed that high glucose impaired the cells’ ability to mature into neuron-like cells, which are crucial for brain development and function. Source: Salimi L, Rahbarghazi R, Jafarian V, Biray Avci Ç, Goker Bagca B, Pinar Ozates N, Khaksar M, Nourazarian A. Heat shock protein 70 modulates neural progenitor cells dynamics in human neuroblastoma SH-SY5Y cells exposed to high glucose content. J Cell Biochem. 2018 Aug;119(8):6482-6491. doi: 10.1002/jcb.26679. Epub 2018 Apr 18. PMID: 29345335. #Neuroscience #GlucoseImpact #BrainHealth #ResearchHighlight #Neuroblastoma
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Our OriGene recombinant LOX protein (TP313323) making waves in the world of metastasis research! 🐭🔍 In a study cited from Cell Rep 2017 (PMID: 28445728), we observed an increased number of metastatic cells in the lungs of mice injected with our LOX protein compared to control mice injected with PBS. This discovery underscores the potential impact of our research tools in advancing cancer studies. 💡 Explore the possibilities with us at booth1229 and see how our products can drive your research forward! Click here to learn more about our recombinant protein offering: https://bit.ly/3G1ITIp #SfN23 #Neuroscience #CancerResearch
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AmberGen is exhibiting today at the VIB Spatial Omics Symposium in Ghent, Belgium. The day started with an excellent presentation by Professor Eva Cuypers of Maastricht University’s M4i - Maastricht for Imaging center. She described her lab’s work performing MALDI Imaging on single cells. Her team used a variety of methods, but we are proud that one of them was AmberGen’s Miralys(tm) MALDI-HiPlex-IHC on a Bruker timsTOF. Using this technology, she was able to image intact proteins in single cells as part of a spatial multiomic workflow. MALDI imaging is incredibly multiomic with the ability to image metabolite and lipid distribution, small molecule drugs, intact proteins, glycans, and now even RNA, all on the same sample on the same imaging instrument. If you would like to learn more, contact us at AmberGen.com. #IMSIS #MSI #spatialbiology #cancer #neuroscience #multiomic #multiomics #proteomics #singlecell
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Spatial Biology, Single cell, Transcriptomics, Proteomics, Imaging, Product Management Leader
RNAscope is the most sensitive and specific ish technology, backed by 10k+ publications. Another unbiased study that compares various ish / Spatial biology methods agrees. #rna #ish #rnascope #spatialbiology
🔬Unlocking Scientific Breakthroughs with RNAscope Technology! 🔬 Navigating the complexities of tissue biology just got easier! #Spatialbiology, powered by tools like #RNAscope, enables researchers to explore tissue content with precision, from localizing genes to understanding cell interactions. But what's the secret to achieving confidence and consistency in these findings? It's a spatial tool that's rigorously tested, easy to implement, and delivers top-notch results swiftly. With over 10,000 peer-reviewed papers supporting its efficacy, RNAscope simplifies spatial analysis, ensuring you reach your conclusions faster and with certainty. As stated in the pre-print from DKFZ German Cancer Research Center: https://lnkd.in/eJhH5Bnx, where the performance of alternative spatial biology methods were compared to the RNAscope HiPlex assay, "The well-established RNAscope method consistently yielded high numbers of transcripts/features per cell for the 10 shared genes". Ready to accelerate your research and publications? Learn how RNAscope by Bio-Techne, ACD can streamline your journey and complement your discovery tools. https://bit.ly/4aOjqj7 #SpatialBiology #RNAscope #spatialanalysis #spatialomics #Neuroscience #oncology #cancer #insitu #singlecell #singlecellspatial
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☑️ *READ DESCRIPTION BELOW:* Development and application of biliary tract cancer patient-derived organoids for chemotherapy drug-sensitivity screening and predictive biomarker discovery Yáñez-Bartolomé M, Macarulla T, Tian TV. The potential of patient-derived organoids in precision medicine of biliary tract cancer. Cell Rep Med. 2023 Nov 21;4(11):101294. doi: 10.1016/j.xcrm.2023.101294. PMID: 37992681; PMCID: PMC10694744. #Gesundheit #Bildung #Fuehrung #Coaching #Mindset #Motivation #Gehirn #Neuroscience #Psychologie #Persoenlichkeitsentwicklung #Kindheit #KeyNoteSpeaker #Humangenetik #Biochemie #Neuroleadership #Ernaehrung #Transformation #Stress #Demografie #Gender #Age #interkulturelleKompetenz #Epigenetik #Veraenderung #EmotionaleIntelligenz #Change #Gesellschaft #Organisationsentwicklung #Philosophie #Beratung # Quantum
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