Perspective Therapeutics’ Post

The fullerenol−doxorubicin conjugate suppressed the proliferation of cancer cell-lines in vitro through a G2-M cell cycle block, resulting in apoptosis. Furthermore, in an in vivo murine tumor model, fullerenol−doxorubicin exhibited comparable antitumor efficacy as free drug without the systemic toxicity of free doxorubicin. Additionally, we demonstrate that the fullerenol platform can be extended to other chemotherapeutic agents, such as the slightly water-soluble cisplatin, and can emerge as a new paradigm in the management of cancer.

【Development of Extraction and Detection Method for a Chemotherapeutic Drug with Phenytoin in Biological Samples】 Full article: https://lnkd.in/eekR6_QQ (Authored by Michael Arnot, et al., from California State University San Marcos, USA.) Phenytoin and #dexamethasone are frequently administrated concurrently to brain #cancer patients. Previous study shows that #phenytoin decreases the levels of dexamethasone in patients. On the other hand, the effect of dexamethasone on phenytoin is inconclusive. Due to the various #interactions among these two drugs, it is important to monitor the concentration of them to determine the ideal dosages among cancer patients. This study develops an efficient and simple #solid_phase_extraction method was developed for simultaneous extraction of phenytoin and dexamethasone from urine examples. 

【Development of Extraction and Detection Method for a Chemotherapeutic Drug with Phenytoin in Biological Samples】 Full article: https://lnkd.in/gtF27WRJ (Authored by Michael Arnot, et al., from California State University San Marcos, USA.)   Phenytoin and #dexamethasone are frequently administrated concurrently to brain #cancer patients. Previous study shows that #phenytoin decreases the levels of dexamethasone in patients. On the other hand, the effect of dexamethasone on phenytoin is inconclusive. Due to the various #interactions among these two drugs, it is important to monitor the concentration of them to determine the ideal dosages among cancer patients. This study develops an efficient and simple #solid_phase_extraction method was developed for simultaneous extraction of phenytoin and dexamethasone from urine examples.

Biomarker-informed treatment planning has expanded possibilities for people with #ColorectalCancer, especially those with metastatic disease. Biomarker test results can provide insight into a patient’s cancer type, predicted tumor response to specific treatment, dosing decisions, and more. ➡️ Discover how biomarker testing works: https://lnkd.in/g8F5uuYw

Please read about the promising results from the first cohort of three patients in our Deltacel-01 Phase 1 clinical trial at Beverly Hills Cancer Center. "Consistency in safety, tolerability, and disease stability is of paramount importance at this stage of testing, and the data thus far bolster our confidence in Deltacel's potential as a transformative treatment," stated Pietro Bersani, Chief Executive Officer of Kiromic BioPharma. “The findings are especially promising considering the robustness of response in the absence of brain metastasis, and the notable reduction in tumor size for the second and the first patient, respectively." #cartcelltherapy #celltherapy #patientsfirst https://lnkd.in/eVycTBzU

Curious about the latest breakthroughs in cancer diagnosis? Gain valuable insights on the trends shaping cancer research, popular biomarkers that matter, and key targets paving the way for more effective treatments. Download the full report for a broad overview of the evolving landscape of current knowledge on cancer biomarkers, an outline of challenges, and an evaluation of growth opportunities for further efforts in solving the remaining problems. #cancerresearch #precisionmedicine #database #lifesciences #pharma #biopharma #medicine #clinicaltrials #biomarkerdiscovery #excelra Bindu Ajithkumar Amar Thyagarajan, PhD Norman Azoulay Chandra Sekhar Pedamallu Jitendra Parekh Aparna Katoch Sapra, PhD. Nishanth Kandepedu PhD Radha Saradhi Reddy (Radha) Thammineni Anil Kumar M.

What are #biomarkers, and why are they important for cancer? They are any biomolecules, structures, or activities that can indicate cancer or its response to treatment. They can help improve survival and quality of life for cancer patients. Check out this report by CAS and Excelra to learn more: https://ow.ly/fyCw50QAn44 #CASInsights

#Healthcareproviders: Biomarker testing is a crucial element in the diagnosis process for patients living with #metastaticbreastcancer. By exploring the distinct characteristics of the cancer cells, biomarkers may reveal a targeted treatment that is specific to your patient's #biomarker. Learn more about this step on the #NoOneMissed website: https://lnkd.in/e2J__vw3

At Labcorp, we're using flow cytometry testing to detect patient immune responses to CAR T-cell cancer therapy. Unlike traditional ELISA methods, this approach analyzes antibodies against the full CAR protein in its native membrane environment, providing a more valid immunogenicity assessment to support treatment safety and efficacy. Read our scientific poster to learn how Labcorp is advancing CAR T-cell therapy: https://lnkd.in/eT3xb2cy #FlowCytometry #AntidrugAntibodies #CellTherapy #CellandGeneTherapy

Targeted cancer therapies are more diverse than ever, including innovations like Designed Ankyrin Repeat Proteins (DARPins). Learn how Molecular Partners is using DARPins to address medical challenges beyond traditional treatments: https://lnkd.in/dXT9fhgW This article is part of our 25th-anniversary series, launched in 2023. If you are interested in shaping and sponsoring a story on the diversity of our industry too, reach out to us. #CancerResearch #SwissBiotech #TargetedTherapies #DARPins #HealthcareInnovation