Phenomenex’s Post

Membrane Chromatography with Sartobind Rapid® A supports downstream processing intensification and allows short process times! 

The Vapourtec Peptide-ExplorerLT is designed for scientists who need to explore and optimise the synthesis of linear peptides. The system produces the same high-quality peptides as Vapourtec's existing Peptide Explorer, but has a more compact footprint and is available at a lower price. CSO Manuel Nuño explained: "Peptide chemists can now access all the benefits of Fast Flow Phase Peptide Synthesis (FF-SPPS) at a price that is comparable with traditional, automated batch synthesizers" Click here to find out more https://lnkd.in/eqviCqqK #PeptideSynthesis #Vapourtec #PeptideChemists

Have you ever struggled with complex bioanalytical workflows for oligonucleotides? With the Waters #OligoWorks SPE Kits simplify this process with standardized protocols, critical reagents, and a flexible format. These kits offer high recovery rates, reproducibility, and LC-MS sensitivity for a wide range of oligonucleotide therapies. 📘 Simplicity: Standard protocols, no capital investment required. 📘 Versatility: Suitable for various oligonucleotides and biomatrices (plasma, urine, tissue). 📘 Time-saving: Minimal method development, quick SPE execution, direct LC-MS compatibility. 📘 Sensitive & Robust: High recovery rates, selectivity, reproducibility. With the OligoWorks WAX sorbent, you achieve over 80% recovery, while other suppliers offer between 20-30% recovery. The reproducibility is superior, and sample preparation is minimal. Issues like protein disruption, extra washes, and workaround elution conditions are a thing of the past with OligoWorks! https://lnkd.in/epd-d8JF https://lnkd.in/ey5XmdSB

Heading to Medica this year? If so, there are a whole host of reasons why stand 1-F034 would be well worth a visit. From assay design, lyo compatibility and accelerated stability trials to full scale commercial manufacture and everything in-between. Use the link below to reserve a time that suits you. https://lnkd.in/e9uF8Jm2 #moleculardiagnostics #invitrodiagnostics #IVD #LAMP #assaydevelopment #CDMO #Lyophilization

This application note demonstrates a two-dimensional liquid chromatography/quadrupole time-of-flight mass spectrometry (2D-LC/Q-TOF) approach to identify the free drug content of an ADC sample. The method combines size exclusion chromatography (SEC) in the first dimension (1 D) and reversed-phase (RP) separation in the second dimension (2 D). This method enables sensitive and straightforward analysis of free drug content in ADC without manual protein precipitation. Read more: https://lnkd.in/gJH4X_WH

Are you involved in the field of Native MS of biomolecule proteins? Consider exploring the NativePAC OBE column for your work. The On-Line Buffer Exchange capability can assist in effectively separating biomolecules while preventing unwanted buffers from complicating the process. For more insights, check out the NativePac OBE-1 SEC Column for Online Sample Preparation on thermofisher.com. Any queries? Feel free to reach out. #Native MS, #Online Buffer Exchange, #proteins

Reliable, fast, highly efficient screening of samples or purification parameters for pDNA, mRNA, AAV, and other large biomolecules with CIM® Monolithic Well Plates. 🔎 They are a robust tool for initial screening of process conditions, which also enable efficient and fast determination of binding, washing, and elution studies. ⏳ Significantly cut the development time by screening multiple conditions at once 📈 Scale up the results from multi-well plate format to preparative CIMmultus line, which can handle industrial volumes. ⚙️ Manufactured according to ANSI standards and automation compatible. 🖐 Can be operated manually with vacuum, centrifuge, and positive pressure. Learn more: https://buff.ly/3TcGSR3 #biotech #chromatography #research #lablife #mRNA #nucleicacids #viralvectors

We are excited to announce the recent publication of our customers' study in Journal of Chromatography A, titled "In-depth Characterization of a Cysteine-Linked ADC Disitamab Vedotin by Multiple LC-MS Analysis Methods and Cutting-Edge Imaged Capillary Isoelectric Focusing Coupled with Native Mass Spectrometry." This research presents a state-of-the-art iCIEF-MS technique under native conditions for detailed analysis of the cysteine-linked ADC, Disitamab Vedotin, in conjunction with traditional online LC-MS approaches. The iCIEF-native MS method preserves the native state of the ADC during both iCIEF separation and MS detection, while also enabling straightforward method transfer from development to quality control (QC). If you're interested in iCIEF-native MS for protein heterogeneity, please refer to the following link: https://lnkd.in/gBUvRWRp