Philippe Tschopp’s Post

𝗔𝗺𝗼𝗿𝗽𝗵𝗼𝘂𝘀 𝘀𝗼𝗹𝗶𝗱 𝗱𝗶𝘀𝗽𝗲𝗿𝘀𝗶𝗼𝗻 𝗼𝗳 𝗮 𝗯𝗶𝗻𝗮𝗿𝘆 𝗳𝗼𝗿𝗺𝘂𝗹𝗮𝘁𝗶𝗼𝗻 𝘄𝗶𝘁𝗵 𝗳𝗲𝗹𝗼𝗱𝗶𝗽𝗶𝗻𝗲 𝗮𝗻𝗱 𝗛𝗣𝗠𝗖 𝗳𝗼𝗿 𝟯𝗗 𝗽𝗿𝗶𝗻𝘁𝗲𝗱 𝗳𝗹𝗼𝗮𝘁𝗶𝗻𝗴 𝘁𝗮𝗯𝗹𝗲𝘁𝘀 by Gloria Mora Castaño, Mónica Millán-Jiménez, Andreas Niederquell, Monica Schönenberger, Fatemeh Shojaie, Pharm.D, Martin Kuentz, Isidoro Caraballo, This study focuses on the combination of three-dimensional printing (3DP) and amorphous solid dispersion (ASD) technologies for the manufacturing of gastroretentive floating tablets. Employing hot melt extrusion (HME) and fused deposition modeling (FDM), the study investigates the development of drug-loaded filaments and 3D printed (3DP) tablets containing felodipine as model drug and hydroxypropyl methylcellulose (HPMC) as the polymeric carrier. Prior to fabrication, solubility parameter estimation and molecular dynamics simulations were applied to predict drug-polymer interactions, which are crucial for ASD formation. Physical bulk and surface characterization complemented the quality control of both drug-loaded filaments and 3DP tablets.  Read more in the article. https://lnkd.in/eDA9sHv5 #pharmaceutical #3Dprinting #ASD

What if you could encapsulate active pharmaceutical ingredients or cells within a resorbable or dissolvable photopolymer shell? There has been much talk about 3D printing pharmaceuticals and implantable drug-eluting devices. The concept makes perfect sense: Use the geometric freedom of 3D printing combined with the excipient material to control the release rate of a second Active Pharmaceutical Ingredient (API). With some 3D printing technologies, such as material jetting, APIs and excipients can be deposited concurrently, producing complex therapies. However, material jetting presents some problems regarding pressures, temperatures, and API suspicion and distribution. One alternative is to suspend the API in a bioinert fluid, which a 3D-printed shell can then encapsulate. By selecting the right materials for the shell and controlling the shell thickness, new patient-specific solutions and therapies could be developed with highly controllable drug release. However, current 3D printing architecture has prevented this approach from gaining traction. At Rayo3D, we have a new solution for manufacturing resorbable and dissolvable devices. Our technology, which we call InLiq-3D, uses a bioinert hydrogel that can be preloaded with an API. The unique aspect of InLiq-3D technology is that the hydrogel also acts as a support structure for the shell material, which can be deposited using simple material extrusion 3D printing. The finished device or drug-eluting capsule can then be removed from the InLiq-3D material, with any residual InLiq-3D washed away in water.

𝗙𝗮𝗯𝗿𝗶𝗰𝗮𝘁𝗶𝗼𝗻 𝗼𝗳 𝗮 𝗖𝗼𝗻𝘁𝗿𝗼𝗹𝗹𝗲𝗱-𝗥𝗲𝗹𝗲𝗮𝘀𝗲 𝗖𝗼𝗿𝗲-𝗦𝗵𝗲𝗹𝗹 𝗙𝗹𝗼𝗮𝘁𝗶𝗻𝗴 𝗧𝗮𝗯𝗹𝗲𝘁 𝗼𝗳 𝗞𝗲𝘁𝗮𝗺𝗶𝗻𝗲 𝗛𝘆𝗱𝗿𝗼𝗰𝗵𝗹𝗼𝗿𝗶𝗱𝗲 𝗨𝘀𝗶𝗻𝗴 𝗮 𝟯𝗗 𝗣𝗿𝗶𝗻𝘁𝗶𝗻𝗴 𝗧𝗲𝗰𝗵𝗻𝗶𝗾𝘂𝗲 𝗳𝗼𝗿 𝗠𝗮𝗻𝗮𝗴𝗲𝗺𝗲𝗻𝘁 𝗼𝗳 𝗥𝗲𝗳𝗿𝗮𝗰𝘁𝗼𝗿𝘆 𝗗𝗲𝗽𝗿𝗲𝘀𝘀𝗶𝗼𝗻𝘀 𝗮𝗻𝗱 𝗖𝗵𝗿𝗼𝗻𝗶𝗰 𝗣𝗮𝗶𝗻 In this study, a novel floating, controlled-release and core-shell oral tablet of ketamine hydrochloride (HCl) was produced using a dual extrusion by 3D printing method. A mixture of #Soluplus® and #Eudragit® RS-PO was extruded by a hot-melt extrusion (#HME) nozzle at 150–160 °C to fabricate the tablet shell, while a second nozzle known as a pressure-assisted syringe (PAS) extruded the etamine HCl in carboxymethyl cellulose gel at room temperature (25 °C) inside the shell. The resulting tablets were optimized based on the United States pharmacopeia standards (USP) for solid dosage forms. #Soluplus by BASF Pharma Solutions #EudragitRSPO by Evonik Health Care

🔴 Video TUMAKER #6 - 3D printing for #biomedical applications. 🔴 In today's video we share the possibilities of additive manufacturing with #pellets in the controlled release of drugs with biomedical utility. The #drug release process is achieved through the use of biopolymers such as polylactic acid or polycaprolactone that can be additivated with biomolecules to produce pellets compatible with Tumaker 3D printers. Just as we can add #biopolymers with biomolecules, we can also add hydroxyapatites, calcium phosphates and similar inorganic salts that promote bone regeneration. For more information on obtaining structures with defined and functionalised geometries in the field of biomedicine, please visit our website or contact our specialists by sending an email to info@tumaker.com. www.tumaker.com #Tumaker #research #materials #innovation #pellet #pharma #pharmaceuticals

How will 3D printing transform pharmaceutical manufacturing? Have a look at my recent discussion with David Alvaro from Pharma's Almanac. #pharma #manufacturing #additivemanufacturing #3Dprinting

Insightful article in the field of 3D drug printing and thanks for the high regard of Triastek！#3DPrinting #drugdevelopment

In this new Q&A on Pharma's Almanac, MilliporeSigma’s Thomas Kipping, sheds light on the evolution, current state, and future prospects of 3D printing in pharma, including applications for creating innovative dosage forms and streamlining the supply of clinical trial material. #pharma #3dprinting #additivemanufacturing #clinicalsupply #osd #pharmaceuticalinnovation

The Rise of 3D Printed Drugs. Imagine being able to take personalized 3D printed tablets tailored for you. Researchers from the Centre for Additive Manufacturing (CfAM) at University of Nottingham used Multi-material Inkjet 3D printing (MM-IJ3DP) to create tablets with a variety of medicines timed to be released a specific times, "enbaling highly customized drug delivery sytems with unparalleled precision." This will also simplify medication regimes and allow for highly personalized medicines for specific patients. Work continues to expand the number of drugs that can be printed. 3Dnatives Centre for Additive Manufacturing (CfAM) at University of Nottingham Yinfeng He University of Nottingham Felicity Rose #3dprinting #3dprinteddrugs #personalizedmecidine #medicine #pharmaceuticals #healthcare #customization #research #futurist #trendforecasting

🔴 Video TUMAKER #6 - 3D printing for #biomedical applications. 🔴 In today's video we share the possibilities of additive manufacturing with #pellets in the controlled release of drugs with biomedical utility. The #drug release process is achieved through the use of biopolymers such as polylactic acid or polycaprolactone that can be additivated with biomolecules to produce pellets compatible with TUMAKER 3D printers. Just as we can add #biopolymers with biomolecules, we can also add hydroxyapatites, calcium phosphates and similar inorganic salts that promote bone regeneration. For more information on obtaining structures with defined and functionalised geometries in the field of biomedicine, please visit our website or contact our specialists by sending an email to info@it3d.com. www.it3d.com #research #materials #innovation #Tumaker #pellet #pharma #pharmaceuticals Toni Iborra

Three-dimensional (3D) printing is a powerful technology that has wide-ranging applications, including many in the pharmaceutical industry. This technical article shows how 3D printing can overcome challenges during formulation development, with a focus on enhancement of bioavailability of active pharmaceutical ingredients (APIs) in solid dispersions. #solidformulation #formulation #osd #drugdevelopment #3Dprinting #excipients