PolarisQB’s Post

Publication update Hello, LinkedIn family, Following up on our foundational work in drug transporters in 2021, we announce the publication of our latest paper, "Distinguishing Molecular Properties of OAT, OATP, and MRP Drug Substrates by Machine Learning". Congratulations to all team members for their dedication and efforts. The study employs machine learning to define key molecular properties of drugs interacting with OAT, OATP, and MRP transporters, enhancing our understanding of drug transport mechanisms. These insights are crucial for developing targeted therapies and understanding drug interactions that can lead to more effective and personalized medical treatments. Please find the paper here:  https://lnkd.in/enxMeCKF #Pharmaceutics #DrugTransporters #MachineLearning #PrecisionMedicine #UCSanDiego

Are molecular glues the key to undruggable targets?   In case you missed it, Dr Benedict CS Cross spoke with Labiotech.eu about the growing interest in the field of molecular glues and the potential for this new modality to open up immense new possibilities in degrader drug development. Read the full article here: https://rb.gy/pnzjdu   #MolecularGlues #DrugDiscovery #DrugDevelopment

Learn more about the digital future for pharma research at #SLAS2024 conference.

I'm excited to share with you a game-changing technology that's transforming the field of biotherapeutic development. The Sartorius Octet system is a cutting-edge platform that's revolutionizing the way we conduct label-free detection for protein quantitation and kinetic characterization. What makes the Octet system so special? Here are a few reasons: ✅ Real-time analysis: The Octet system allows for the monitoring of biomolecular interactions in real-time, providing immediate insights into binding kinetics, affinity, and specificity. ✅ Versatility: Whether you're working with small molecules or large proteins, the Octet system is designed to handle a wide range of samples, making it a versatile tool for any lab. ✅ Efficiency: With the ability to analyze up to 96 samples simultaneously, the Octet system significantly increases throughput, saving valuable time and resources. The Sartorius Octet system is more than just a piece of equipment; it's a gateway to faster, more accurate discoveries that can lead to life-changing therapies. If you're interested in learning more about the capabilities of the Octet system, check out the link below: https://lnkd.in/gGCHC7P5 #Biotechnology #ProteinAnalysis #SartoriusOctet #Innovation #LabTech #ScienceAndTechnology

Hold onto your seats because our next webinar is a wild card! In 'What The Drug!?' we start by unveiling a drug discovery challenge, then dive into a hands-on session to address it live on stream. No script, no preparations. Just a target and some scientists doing drug design commenting their decisions and ideas. Excited to see what can be done in a short time frame? Tune in on Thursday June 13th at 4 pm (CEST, Berlin time)! #compchem #medchem #drugdiscovery #drugdesign #CADD #virtualscreening

A lot of preclinical formulations are solutions. Ease of dosing and performance being the main drivers. Making a solution is only half the battle. Assessing performance in vitro, ensuring you don't get precipitation is vital. Species, volumes, residence times, pH - all might be critical to success. If you want to have the best chance of winning, speak to people who provide solutions to your problems, after they understand what they are. Were attending BOS in Basel later this month. Reach out if you would like a conversation to understand how the team at #Sygnature can advance your projects towards patients in need. Short video of an emulsion being formed. No drug precipitated over any time frame. Good to move forward.

Assay technologies and methodologies have been developed to identify chemicals that can be used for drug discovery. Miniaturized assays and encoded libraries help to increase the speed and efficiency of this process. To create more accurate formats, complex cell models of disease states are being utilized. This review article focuses on recent developments in high-throughput assay technologies that are used to identify starting points for drug discovery. Furthermore, it will provide recommendations for selecting high-quality leads that can be used for drug development. #AssayTechnologies #DrugDiscovery #HighThroughputAssays #EncodedLibraries #CellModels #DrugDevelopment #ScienceAndTechnology #ResearchAndDevelopment

What are the benefits to implementing automated liquid handling in your workflows? - Increased accuracy 🔬 - Higher throughput ⏩ - Reproducibility 🏆 Streamline your laboratory processes by accurately dispensing liquids for various applications including genomics, drug discovery and diagnostics. Find out more - https://bit.ly/3VFw5im

Download the infographic to learn more about flow cytometry in drug discovery: https://lnkd.in/gQ67HFNR Recent technological advances have removed several process bottlenecks and helped flow cytometry gain widespread use in high-throughput screening. This infographic provides information on how to optimize your workflows to enhance the drug discovery process. #FlowCytometry #HighThroughputScreening #DrugDiscovery #LabAutomation #LifeScience

⏱️ Enabling Early Approval with Smarter Clinical Evidence Generation ⏱️ Our latest case study showcases how KerusCloud, our simulation-guided study design tool, empowered a small biotechnology company to accelerate the approval process for a new antibacterial treatment for C. difficile (CDI). Facing the challenge of developing an impractical study plan requiring ~1000 patients, the company leveraged KerusCloud to evaluate alternative, feasible development plans. By processing data from various sources and generating synthetic datasets, KerusCloud simulated thousands of studies, allowing rapid in silico assessment of different study design parameters. This innovative approach enabled the company to devise an optimised development strategy. Key Results: 💰 The approach saved the sponsor £18M in development costs. ⏱️ Time to market was reduced by 3-5 years. 🔍 KerusCloud identified an alternative development plan that reduced the patient requirement from 1000 to 180. 📊 The evidence package generated was sufficient for early regulatory approval. 📝 The simulation results provided clear guidance from FDA and EMA on proceeding with the optimised study design. This case study underscores the transformative impact of KerusCloud in streamlining clinical trial design, reducing costs, and accelerating the availability of new treatments to patients in need. Learn more: https://lnkd.in/d7KS_dqf #KerusCloud #Biotechnology #ClinicalResearch #StudyDesign #ClinicalTrials #DrugDevelopment #CDITreatment