Polyplus now part of Sartorius’ Post

AmbioPharm peptide scientists have a wealth of experience. Whether your project is a straightforward linear peptide, or a complex peptide macrocycle, we have the experience and equipment to meet your project needs. Our scientists have experience with synthesizing a wide variety of peptides including: · linear · multi-disulfide bonded · macrocyclic · stapled · “clicked” · thioether-constrained · pegylated · fatty acylated · peptide-protein conjugated · peptide-chelates · MAP constructs and more We can also cover a wide range of projects, from early clinical to large commercial scales. Contact us to learn more about our capabilities and how we can help you with your next peptide project. https://lnkd.in/ewACd_9g #cgmp #peptides #cdmo #innovation #api #drugdevelopment #peptidesynthesis #peptidetherapeutics

Salcaprozate sodium (SNAC) is a permeation enhancer that can increase the permeability of the intestinal epithelial cell membrane and used to deliver macromolecules in an oral formulation. #SNAC is a component of NovoNordisk's #Rybelsus, the oral version of #semaglutide, which has been approved by the FDA and EMA. #NovoNordisk acquired this technology through their $1.8B acquisition of Emisphere in November 2020. Entera’s (ENTX) oral delivery technology (N-Tab™) combines SNAC with other stabilizing agents to synergistically protect & transport large molecules by: 1. Preventing the degradation of the therapeutic protein in the GI tract, which maintains the integrity of the protein (stability) 2. Enhancing peptide absorption by increasing transcellular transport (bioavailability)

Advance in transdermal delivery of calcitonin using nanostructured lipid carrier-based emulgel

Rhode Peptide Lip Treatment Searches: 49.5k Change: ⬆ +99x Period: 5 years

There are plenty of papers devoted to covalent binders these days and it is not so easy to follow the upcoming literature in the field, therefore I really enjoy reading reviews devoted to the developments in recent years, like this one: https://lnkd.in/eGNEy7iF The review deals with recent examples of advanced acrylamide warheads (e.g. fluorinated and cyano acrylamides) as well as some ketoamide warheads that have been applied in the design of covalent inhibitors for various proteins. It is always amazing to see how slight variations in the warhead can significantly improve physicochemical properties, enhance selectivity, and lead to more favorable pharmacokinetics! One of the most exciting applications of acrylamides and CN-acrylamides (which is also covered in the review) is their incorporation into PROTAC molecules (proteolysis-targeting chimeras), which has shown great potential for enhancing the effectiveness and properties of these therapeutic agents. We at Enamine Germany have great experience in the design and synthesis of molecules with various covalent warheads, in particular, acrylamides. In combination with good experience in the TPD area, our team can be a reliable partner in research in this field. https://lnkd.in/e_PZ5eEP #Covalentbinders #acrylamides #Medicinalchemistry #Drugdiscovery #enaminegermany

Highly selective kit for Cyp1A1 activity measurement by Starlight. A very useful kit to characterize our hepatic assay systems. #Liver #Hepatocytes #CYP1A1 #CYP450

𝗖𝗵𝗶𝘁𝗼𝘀𝗮𝗻-𝗯𝗮𝘀𝗲𝗱 𝗯𝘂𝗰𝗰𝗮𝗹 𝗺𝘂𝗰𝗼𝗮𝗱𝗵𝗲𝘀𝗶𝘃𝗲 𝗯𝗶𝗹𝗮𝘆𝗲𝗿 𝘁𝗮𝗯𝗹𝗲𝘁𝘀 𝗲𝗻𝗵𝗮𝗻𝗰𝗲 𝘁𝗵𝗲 𝗯𝗶𝗼𝗮𝘃𝗮𝗶𝗹𝗮𝗯𝗶𝗹𝗶𝘁𝘆 𝗼𝗳 𝘁𝗶𝘇𝗮𝗻𝗶𝗱𝗶𝗻𝗲 𝗵𝘆𝗱𝗿𝗼𝗰𝗵𝗹𝗼𝗿𝗶𝗱𝗲 𝗯𝘆 𝗯𝘆𝗽𝗮𝘀𝘀𝗶𝗻𝗴 𝘁𝗵𝗲 𝗳𝗶𝗿𝘀𝘁-𝗽𝗮𝘀𝘀 𝗺𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝘀𝗺 Tizanidine hydrochloride (TZN) is an antimuscarinic agent used in the treatment of pain-related spasms, multiple sclerosis, and stroke-related spasticity. It has low oral bioavailability (40 %) due to excessive first-pass metabolism in the liver. The aim of this project was to enhance the systemic bioavailability of TZN by developing buccal mucoadhesive bilayer tablet formulations using chitosan salts with molecular weights of 136 kDa (7 cP) and 169 kDa (10 cP). Structural characterisation of chitosans and their salts was performed by FTIR, 1H NMR, DSC, TGA, and XRD analyses. Soluble chitosan salts, chitosan glutamate and chitosan chloride, for the adhesive layer, and insoluble ethyl cellulose for the impermeable backing layer were selected as polymers to fabricate the buccal tablets by direct compression method. #pharmaceutical #excipient #chitosan

Normoftal custom peptide synthesis Product information: Product name: Normoftal Source: Synthesis Appearance: white powder Purity: >95.0% Shelf life:> 2 years Notice: For research use only #peptide #custompeptide #peptidesynthesis #Normoftal

DSPE-PEG-PBP,DSPE is a phospholipid commonly used in the formulation of lipid-based drug delivery systems,providing stability and structure to the nanoparticles.PEGylation involves attaching PEG chains to the molecule,offering improved stability, circulation time, and reduced immunogenicity.The peptide sequence PBP(CDAEWVDVS) is attached to the PEG chain.  #DSPE #PEG #PBP #CDAEWVDVS #polyethylene #glycol #peptide https://lnkd.in/gVSE5myq

Liposomes: * First Liposome developed in 1965 by Professor Bangham. His initial objective was to disperse lipophilic compounds (encapsulated in liposomes) in aqueous solutions. * What is a liposome? A liposome is a spherical nanovesicle formed mainly by phospholipids, which adopt a lipid bilayer structure when they are in aqueous dispersions. * Critical Process Parameters for Liposomal Formulation (CPP): 1) Phase transition temp: -Phase transition temp important for downstream process during liposomal manufacturing which includes, different formulation processes like a) Extrusion b) Emulsification c) Sonication d) Filtration 2) pH and Storage temperature for liposomes. - Its important to determine the final pH for formulation so it can be compatible with target site, The storage temperature is important to ensure stability of liposomal formulation during its shelf life. 3) Choice of lipids used for manufacturing of liposomes - Its very important to choose proper lipid source as its directly impact your product quality profile and drug release profile from liposomes. - During development of generic version for liposomes its recommended to use the same lipid source as innovator and maintain the drug to lipid ratio as claimed in Innovator. - Higher temperature during manufacturing of liposome can lead to formation of lysophospholipid which can lead to liposome bilayer leakage. - Oxidation of unsaturated fatty acid tails can also lead to liposome bilayer leakage. -Proper selection of surface charge and buffer species is critical as wrong selection can lead to aggregation as well as accelerated hydrolysis of lipids. - Cholesterol can be used in liposomal formulation to broadens liquid crystalline temperature range, prevents water penetration in lipids and fills the gaps in lipids bilayer. Information and Image Source: Google #novel drug delivery systems #complex injectables #liposomes #lipid carriers #nano particles #oncology #complexgenerics