A collaborative study conducted at Universit�� de Caen Normandie, Centre François Baclesse, The Horia Hulubei National Institute of Physics and Nuclear Engineering - IFIN-HH, and the University of Bucharest utilized the Precision X-Ray, Inc. CellRad Irradiator to evaluate the differential effects of DNA damage repair inhibitors and high linear energy transfer (LET) irradiation on chondrosarcoma and chondrocyte cells.
Chondrosarcoma, a rare malignant tumor that develops in bone and cartilage, is primarily treated through surgical removal, often with a margin of healthy tissue. However, when complete surgical resection isn't feasible, radiation therapy and chemotherapy are combined with surgery, though their effectiveness is generally low. Therefore, new therapeutic strategies are essential in these cases. This research aims to explore the potential of Olaparib (PARP inhibitors) to radiosensitize chondrosarcoma and chondrocyte cells, particularly focusing on how different IDH statuses respond to C-ion and X-ray radiation.
For this study, the chondrosarcoma OUMS27 cell line, the JJ012 cell line (primary grade II chondrosarcoma), and the chondrocyte cell line MC615 were irradiated with X-rays at doses ranging from 1 to 6 Gy using our CellRad system (Precision X-ray, Madison, CT, USA). The system was equipped with a copper filter, operating at a tube tension of 129 keV and an intensity of 4.7 mA, corresponding to a dose rate of 1 Gy/min.
The study reveals the complexity of DNA repair mechanisms and cell responses to DNA damage, dependent on LET and the specific DNA repair inhibitors used. PARP inhibition showed promising results, especially in combination with X-ray irradiation. This study demonstrates the critical role the Precision X-ray CellRad system plays in understanding the mechanisms behind chondrosarcoma’s resistance to treatments.
We are proud to see how Universit�� de Caen Normandie and the University of Bucharest maximize the potential of our technology to discover new approaches in cancer treatment!
Link: https://lnkd.in/eKHtT3s2
#CancerResearch #Radiotherapy #PrecisionXRay #CellRad #NormandieUniversite #Chemotherapy
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