📔[BROCHURE] 𝐌𝐨𝐧𝐢𝐭𝐨𝐫 𝐁𝐢𝐨𝐥𝐨𝐠𝐢𝐜𝐚𝐥 𝐂𝐡𝐚𝐧𝐠𝐞𝐬 𝐢𝐧 3𝐃 𝐂𝐞𝐥𝐥 𝐂𝐮𝐥𝐭𝐮𝐫𝐞𝐬 🧫 Three-dimensional (3D) cell cultures are widely employed from basic research to drug discovery/development because of their physiological relevance. The use of assays originally designed for cell monolayers (2D) or suspensions, however, may yield inaccurate or misleading results. ✅ Many Promega assays have already been validated to show good performance and produce accurate results with different 3D cell culture models. 👉 Explore more: https://bit.ly/4aIhOYE
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New Oligonucleotide Virtual Lab 💻 Synthetic oligonucleotides (including small interfering RNA, antisense oligonucleotides, aptamers) have become fast-growing modalities in recent years. With the development of these candidates comes increased need for robust analytical methods and easy-to-use data analysis workflows to characterize them. Commonly sought-after attributes of oligonucleotides include the mass, purity (and relative quantity of impurities present), and sequence. Check out the Oligonucleotide Workflow Virtual Lab:
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Our latest preprint (bioRxiv) describes a mathematical method for predicting the cardiotoxicity of novel drugs from their effect on just two ion-currents in the heart. The method is based on the concept of the axis of arrhythmia. Here, we describe describe two independent methods to derive the axis (one from a biophysical cell model, the other from a drug dataset) which both converge to the same result. Getting such good agreement between domains is quite rare, and it gives us much higher confidence in the findings. https://lnkd.in/g9apKs4Q
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Discover how our cutting-edge NanoBRET® Target Engagement (TE) Assay is revolutionising drug discovery in a new article. Gain valuable insights from one Promega scientist and learn how #NanoBRET TE is successfully bridging the biochemical and functional cellular assay divide. Read here: https://bit.ly/3Urb0Yl
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Did you hear about our latest enhancement to Sarah Nexus? 👀 We've introduced a new #ChromosomeDamage prediction model, which enables you to perform comprehensive #genotoxic assessments by supporting mutagenicity and chromosome damage predictions within a single, powerful in silico platform. The model leverages in vitro chromosome aberration and micronucleus assay data, alongside in vivo test data, offering a robust and reliable tool for assessing genotoxic risk. For more info on how to sponsor this additional module, get in touch: https://buff.ly/3Xh3Nvk 👈 #SarahNexus #InSilico #Genotoxicity
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A novel hybrid high speed mass spectrometer allows rapid transition from biomarker candidates to targeted clinical tests using 15N labeled proteins https://lnkd.in/ex8bGNW3
A novel hybrid high speed mass spectrometer allows rapid transition from biomarker candidates to targeted clinical tests using 15N labeled proteins
view.highspot.com
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Gain valuable insights from Fahimeh Tabatabaei, Study Director at iFyber, as she discusses the importance of comprehensive in vitro testing methods. Explore the significance of cell culture models mirroring primary osteoblast cells and the necessity of evaluating biomaterial functionality at multiple levels. https://bit.ly/3OdHeEU
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To tailor a more physiological in vitro cell environment, #3Dcellculture systems often contain extracellular matrix (ECM), which provides structural support and also plays a fundamental role in dynamic signals that influence cell morphology and function. In this application note, we demonstrate how complex multi-step assays and data acquisition from #3Dcellmodels in ECM can be streamlined with the #pumasystem. https://lnkd.in/gYUpf4Ht #3Dcellassay #flowchips #biotech
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Looking for tips and applications to correctly perform enzyme-linked immunosorbent assays (ELISAs)? The #ELISA Master Guide shares advice from PhD-level cellular and molecular #biologists on how to perform ELISAs and provides real-world insights for optimal #liquidhandling and tool selection. https://bit.ly/468gFrO
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