Promega Switzerland’s Post

📢 Revolutionary Model Predicts Nanobody Melting Temperatures! 🌟 Scientists are exploring the melting temperatures of nanobodies, promising agents in biotherapeutics. 🔬 A new computational model, TEMPRO, predicts these temperatures with high accuracy using antibody sequences, streamlining research processes. 📊 With a mean absolute error of just 4.03°C, it can significantly cut costs in nanobody development. 📦 The model and data are publicly accessible for further research. #BioprocessUpdates #Nanobodies #Therapeutics #Biotechnology #ComputationalModel #TEMPRO #MeltingTemperature #ResearchInnovation #Biotherapeutics #ScientificResearch #OpenData #Nanotechnology #DrugDevelopment #PrecisionMedicine #CostEffectiveResearch #AntibodyEngineering ▷ Read the full article here: 📎 https://lnkd.in/d8z27vBn

💡News in single-cell tech! Meet Partillion Bioscience, a new player transforming how we study single cells. 🧐 Want to know what makes this innovation a game-changer? Check out our latest blog post: https://lnkd.in/dWQTgkCw #secretome #SingleCell #Innovation #PartillionBioscience #NewTech #SingleCellWorld

Upcoming webinar alert! Join us for "Innovations in Protein Modeling: How Physics is Impacting Industrial Drug Discovery," hosted by The Protein Society on Thursday, November 7th at 10:00am ET. @Jennifer Knight will lead a discussion with experts from Nested Therapeutics and UCB on the practical applications of Schrödinger tools in protein modeling. Featured Talks: - Dr. Aysegul Ozen, Nested Therapeutics, will delve into "Driving drug discovery by physics-based simulations: Multifaceted impact beyond chemistry prioritization." - Dr. Marie Ledecq, UCB, will share insights on "How molecular simulations help to solve cryogenic electron microscopy structures of protein/drug complexes." - Dr. Jennifer Knight, Schrödinger, will present "Achieving kinome-wide selectivity in drug discovery campaigns through free energy calculations: a Wee1 case study." Register now to explore the cutting-edge advancements in protein modeling and their significant role in industrial drug discovery: [Link to Register] #ProteinModeling #DrugDiscovery #Webinar #Science #Innovations

Small molecules are valuable in research and life sciences, easily penetrating cell membranes to modulate intracellular processes. Their well-defined properties and diverse structures make them crucial for studying biological pathways and developing therapies. Compound screening libraries help uncover novel compounds with desired biological activities, facilitating the discovery of lead compounds with drug-like properties and accelerating the drug discovery process. 👉 Discover our large portfolio of small molecules, inhibitors, activators, and compound screening libraries. More information here: https://lnkd.in/exEvqyRu #SmallMolecules #CompoundScreeningLibraries #DrugDiscovery #Research #Lifesciences

Unlocking the Future of Nanomedicine with Polymeric Micelles! 🌐 Horacio Cabral's groundbreaking work delves into the immense potential of polymeric micelles as nanomedicines. 🚀 These micelles, formed through intricate interactions between block copolymers and bioactive agents, are revolutionizing drug delivery. 💊 This Review explores the design intricacies, highlighting the role of polymer/payload interactions and the interplay with biological interfaces. 🧬 The chemistry and engineering of block copolymers take center stage, shaping polymeric micelles for effective therapeutics delivery. Discover how these micelles respond to stimuli, enabling precise drug targeting at both macro and subcellular levels. 🎯 Horacio Cabral's work propels the field forward, offering a glimpse into the future of nanomedicine. #nanomedicine #drugdiscovery #polymers

Our latest work on the #cryopreservation and #biobanking of spheroids has been published in Biomaterials Science and Engineering Manchester Institute of Biotechnology . We explore how inducing ice nucleation at higher temperatures protects spheroids. We show the nucleation prevents the solvent-exposed cells from shedding, using GFP-expressing cells for resolution. This is helping us to design methods and tools to bank 3D cell models. Why? 3D #cellmodels are more predictive of human outcomes in drug screening than common 2D cell culture, but not everyone has the resources/skills to make them. If we can freeze them better, they can be used 'off the shelf'. Our longer term vision is to freeze primary-cell spheroids/organoids to replace #animaltesting with more predictive, cheaper and accessible models. Read the work here: https://lnkd.in/eP5cNNR3

Unlocking drug discovery's hidden potential: the power of Omics Data Discover how Evotec is revolutionizing drug discovery by leveraging cutting-edge quantitative proteomics. Our latest white paper delves into the innovative techniques and comprehensive services that are driving breakthroughs in the field. Key Highlights: - Advanced Proteomics: Uncovering novel drug targets with precision. - High-Throughput Screening: Efficiently identifying potential drug candidates. - Innovative Technologies: Tackling the undruggable with mass spectrometry-based approaches. Download the white paper now and explore how we are transforming the landscape of drug discovery: https://hubs.ly/Q02RTVT90 #DrugDiscovery #Proteomics #Biotech #ResearchNeverStops

Hello, Recently, I attended a one-day seminar on the Nano Drug Delivery System. I learned about how nanomedicine and nanodelivery systems are a relatively new but rapidly growing field. These systems use materials at the nanoscale to deliver therapeutic agents or diagnostic tools to specific targets in a controlled way. Nanotechnology offers many advantages for treating chronic diseases by delivering precise medicines to specific sites. There have been several successful applications of nanomedicine, including using chemotherapeutic agents, biological agents, and immunotherapeutic agents to treat various diseases. #nanomedicine #nanotechnology #immunotherapy #biologicalagents #medicalresearch

🧬 Bioprinting Meets Organ-on-Chip: A Synergy Driving Innovation 🖨️ In recent years, bioprinting has rapidly gained traction as a groundbreaking field of study. At Beonchip, we're eager to explore how the integration of bioprinting technology with organ-on-chip platforms is transforming in vitro cell culture methodologies and participate in the process. This fusion of two cutting-edge technologies is opening new avenues for creating more precise, scalable, and versatile cell culture models. Our latest technical note delves into the promising possibilities arising from this synergy, setting the stage for innovative advancements in biomedical research and drug testing. Curious to learn more? Check out our latest post at https://lnkd.in/dCp7qQeM. #Bioprinting #OrganOnChip #Innovation #InVitro #BiomedicalResearch #Beonchip

They are so simple to use. They live longer. BS. - - - The number 1️⃣ reason why cell lines are still a thing, it's because they are cheap. The number 2️⃣ reason is that they are reproducible (at low passages). The number 3️⃣ reason is that they are published. By everyone. I can't blame people for using cell lines. There is hardly an alternative. Right? But which story would you be able to tell if you could access primary tumor material, associated normal adjacent tissue and matched materials (PBMCs, lymphnodes etc) ? Think about it for a moment. The whole story, from beginning to end. Now write it down. If you want to know how to make this a reality, write "MATCH" below to get our guide. ————————— I am Davide - Founder & CEO of Sellomics . With my life science company I bring innovative cell biology solutions to European researchers in #Academia, #Pharma, #Biotech, and #IVD. Like my content? Click my name + follow + 🔔