Promega Corporation ’s Post

Exciting advances in personalized oncology care! 🧑⚕️💻 COMSOL Multiphysics® is being used to develop a simulation app that could revolutionize cancer treatment by offering more personalized therapies. Through advanced simulation techniques, this technology helps predict and optimize the effectiveness of various treatment plans for each individual patient. This innovation could greatly enhance precision medicine, making treatments more tailored and effective. Although my research focused on a different field back in 2020 when I worked there—pasteurization, as part of my Ph.D. thesis—it was an incredible experience collaborating with ModProLab and UNIBAS. I wish them all the best as they contribute to such an inspiring cause, fighting cancer through innovation and research. 🌟💪 #Oncology #Research #Simulation #Innovation #Europe https://lnkd.in/e4CYxwQK

Electrical Stimulation: A New Frontier in Cancer Therapy? It is time for a good bedtime story about mesenchymal stem cells! MSCs are widely known for their regenerative potential - but what if they could also be reprogrammed to fight cancer? Researchers have now explored a novel approach to transform MSCs and T cells into induced tumor-suppressing (iTS) cells by electrical stimulation (ES). These reprogrammed cells secrete tumor-inhibiting factors, offering a new, non-invasive strategy to combat metastatic cancer. How did they do it? Cells used: Mesenchymal stem cells (MSCs) and Jurkat T cells. Stimulation conditions: 50 mV/cm, 10–100 Hz for 1 hour. Analysis: Conditioned medium (CM) from these electrically stimulated cells was tested for tumor suppression. Results: ✅ Electrically stimulated MSCs released tumor-suppressing factors that reduced cancer cell viability. ✅ Inhibited tumor cell migration and 3D spheroid growth. ✅ Lowered osteoclast maturation (preventing bone degradation). ✅ Enhanced osteoblast differentiation, aiding bone health. ✅ Proteomic analysis revealed tumor-suppressing proteins (e.g., Histone H4). ✅ Knocking down Piezo1 impaired the tumor-suppressing effects, proving its role in ES-driven cell transformation. What did we learn? 🔹 Electrical stimulation can reprogram MSCs and T cells to secrete tumor-suppressing factors—a non-invasive and promising approach for cancer therapy. 🔹 Piezo1, a mechanosensitive ion channel, plays a key role in this process. 🔹 Combining ES with chemotherapy (Taxol) improved effectiveness, reducing required drug doses. This study highlights the potential of electrical stimulation as an innovative cancer therapy. Could this approach reshape future treatments? Reference: https://lnkd.in/eesNiREx #CancerResearch #MesenchymalStemCells #StemCells #ElectricalStimulation #TumorSuppression #OncologyInnovation

Research Focus: Enhancing Brain Cancer Outcome Predictions Through Optimal Imaging Criteria

OncoAssure Biopsy-Based 6-gene Prostate Cancer Prognostic Test Improves Risk Stratification Over Standard Clinical and Pathological Information and Optimises Patient Management After Diagnosis of Prostate Cancer

Research Focus: Enhancing Brain Cancer Outcome Predictions Through Optimal Imaging Criteria

OncoAssure Biopsy-Based 6-gene Prostate Cancer Prognostic Test Improves Risk Stratification Over Standard Clinical and Pathological Information and Optimises Patient Management After Diagnosis of Prostate Cancer https://lnkd.in/dkpY5Shp

Check out my new paper published in PNAS with co-lead Ilaria Baldassarri on using engineered human bone marrow models to better understand #breastcancer remodeling of the hematopoietic niche!! Cancer affects all of us, either directly or indirectly. With the 5y survival rate of only 30% following the spread of BC, we were motivated to explore new ways of predicting outcomes & improving treatment responses tailored to individual patients. We bioengineered human tissue models of the BM with/without the incorporation of BC cell lines. This enabled us to study both colonization of the BM, changes to hematopoiesis/blood lineages, and remodeling of the stromal niche. Really proud of this work, & especially of co-lead Ilaria, with it being her first, first-author paper! Thanks to all the authors that contributed, as well as our support from Columbia University, Columbia University Biomedical Engineering, The National Institutes of Health National Cancer Institute (NCI), National Institute of Biomedical Imaging and Bioengineering (NIBIB), Chan Zuckerberg Initiative Chan Zuckerberg Biohub Network, National Center for Advancing Translational Sciences (NCATS), & National Science Foundation (NSF). https://lnkd.in/gT5HbGJ9 Gordana Vunjak-Novakovic Pamela Graney, PhD Alan Chramiec, PhD

A promising development in pancreatic cancer diagnosis! Researchers at the Weizmann Institute of Science, led by Prof. Lucio Frydman and in collaboration with Prof. Avigdor Scherz's team, have demonstrated a novel magnetic resonance imaging (MRI) approach that could significantly improve the detection of pancreatic tumours. This innovative method has the potential to make tumors more readily identifiable in MRI scans, paving the way for earlier diagnoses and better treatment outcomes for pancreatic cancer patients. This collaborative research exemplifies the importance of interdisciplinary efforts in advancing medical diagnostics. The successful development of this new MRI approach would be a significant breakthrough in the fight against pancreatic cancer. #scienceresearch #MRI #collaboration

#TrendingWithImpact: On July 2, 2024, researchers S.H. Tolmeijer, E. Boerrigter, N.P. Van Erp, and Niven Mehra from Radboud University Medical Center published a new editorial paper in Oncotarget, entitled, “Using early on-treatment circulating tumor DNA measurements as response assessment in metastatic castration resistant prostate cancer.” “[...] results of Tolmeijer et al. show the promise of on-treatment ctDNA detection as early read out for treatment response to potentially help guide treatment management of patients with mCRPC.” #PressRelease: https://lnkd.in/dNYewC5N #cancerresearch #prostatecancer #DNA #oncology #openaccess #editorial #openscience #peerreviewed #journal #publication #publishing #trending #meded