Proteomics International’s Post

➡️ New Research Published: Happy to share our latest study on enhancing the diagnostic value of optical spectral transmission (#OST) technology (#HandScan) for detection of inflammatory #arthritis. 🔎 Scope: We explored how adjusting OST cut-off scores based on patient-specific factors like #age and #sex can improve diagnostic accuracy. By integrating these factors, our study moreover evaluated patient-tailored statistical models that estimate the likelihood of a positive inflammatory arthritis diagnosis for each individual. ✅ Key Findings: * Customized cut-off values seem to offer higher diagnostic value than universal cut-offs. * The suggested clinical models provide clinicians with a personalized, data-driven approach to assess the probability of inflammatory arthritis based on OST readings and patient-specific characteristics. This is the first study to introduce patient-related OST cut-off values, paving the way for more personalized and precise arthritis diagnostics. #ArthritisResTher #PersonalizedMedicine #ClinicalResearch #Rheumatology #RheumazentrumRLP

Pain is a universal human experience, affecting around 20% of the population. It is complex and can be initiated by several distinct conditions, posing unique therapeutic challenges that require a tailored treatment approach. Current pain management options have limitations and there is a need for better therapies. We've created an infographic tracking progress in the discovery of therapies for neuropathic pain, outlining new drug targets and candidates in preclinical development and clinical trials. See the full infographic "Tackling the Hidden Epidemic: Advances in Pain Management Drug Discovery" at https://okt.to/YOZG4b #Infographic #PainManagement #NeurologyResearch #ResearchChemicals

PRACTICAL MANAGEMENT OF COMPLEX CANCER PAIN 2E (Oxford Specialist Handbooks in Pain Medicine)

🔍 Check out the publication that introduces a framework for automatic hand range of motion evaluation of rheumatoid arthritis patients. 📚 The framework presented in this study evaluates finger movement patterns in #Rheumatoid #Arthritis patients using 3D hand pose estimation, allowing real-time visualization and computation of flexion and abduction angles. Data from RA patients and controls were compared using time series similarity analysis, achieving 89% accuracy in unseen subjects and 82% in robust statistical evaluation. This approach enables efficient characterisation of RA in patients with minimal intervention and reduced evaluation time. Read the full paper: https://lnkd.in/gDF37zNG #rheumatoidarthritis #handposeestimation #Computervision #arthritisresearch #healthtech #healthtechinnovation

MUST READ in NEJM … IMPORTANT UPDATE from Vaishali Sanchorawala at Boston Medical Center (BMC) … here’s the cliff notes: Consider in differential diagnosis ▶️Nephrotic range proteinuria ▶️Unexplained non ischemic cardiomyopathy ▶️Peripheral neuropathy ▶️Unexplained hepatomegaly ▶️Atypical multiple myeloma 👉🏽nejm.org/doi/full/10.10…

In the pursuit of groundbreaking treatments for rheumatoid arthritis (RA) Learn the unfolding narrative of this cutting-edge research, where each test patient becomes a crucial participant in advancing the frontiers of medical innovation. https://lnkd.in/g97t7tDK #arthritisresearch #arthritisrelief #arthritismanagement #arthritisproblems #arthritiswarrior #arthritis

DAILY DOSE‼️ Pain Management for Cancer Patients: The Importance of Research. Keep reading to learn what the authors say about medication combinations and interventions. https://hubs.li/Q02h3P-G0 #PAINWeek #PAINWeek2024 #PAINWeekconference #healthcareprofessionals #PAINWeeklasvegas #thecosmopolitanoflasvegas #pain #painmanagement #painmedications #PAINWeekattendees #PAINWeekcme #cme #ce #PAINWeek2024conference #painconference #painsponsors #paineducation #paintopics #paincourses #opioids #opioidusedisorder #nonopioidmedicines #polypharmacy #MusculoskeletalPain #painmanagement #MusculoskeletalPain #BehavioralPainManagement #Neuromodulation

🌟 𝗧𝗵𝗲 𝗥𝗼𝗹𝗲 𝗼𝗳 𝗣𝗗𝗣𝗔 𝗶𝗻 𝗛𝗲𝗮𝗹𝗶𝗻𝗴 𝗮𝗻𝗱 𝗥𝗲𝗴𝗲𝗻𝗲𝗿𝗮𝘁𝗶𝗼𝗻: 𝗥𝗲𝗮𝗹-𝗟𝗶𝗳𝗲 𝗦𝘂𝗰𝗰𝗲𝘀𝘀 𝗦𝘁𝗼𝗿𝗶𝗲𝘀! 🌟 We’re thrilled to share some incredible real-life applications of Placenta Derived Protein Array (PDPA) in clinical settings. 🧬✨ 🔬 𝗣𝗗𝗣𝗔 𝗶𝗻 𝗔𝗰𝘁𝗶𝗼𝗻: PDPA leverages the power of placental proteins to promote healing and regeneration. These proteins are collected through a non-invasive, ethical process, making PDPA a revolutionary tool in regenerative medicine. 💡 𝗖𝗮𝘀𝗲 𝗦𝘁𝘂𝗱𝗶𝗲𝘀 𝗮𝗻𝗱 𝗦𝘂𝗰𝗰𝗲𝘀𝘀 𝗦𝘁𝗼𝗿𝗶𝗲𝘀: 𝗣𝗮𝘁𝗶𝗲𝗻𝘁 𝗥𝗲𝗰𝗼𝘃𝗲𝗿𝘆: Jane, a 56-year-old arthritis patient, experienced significant improvement in joint pain and mobility after PDPA treatment. "I can now enjoy my daily walks without the constant pain that used to hinder me," she says. 🌟 𝗖𝗹𝗶𝗻𝗶𝗰𝗮𝗹 𝗔𝗽𝗽𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻: Dr. Smith, a leading rheumatologist, highlights a study where PDPA was used to treat patients with severe cartilage damage. "The results were remarkable. Patients showed rapid recovery and reduced inflammation," he explains. 📈 𝗦𝗽𝗼𝗿𝘁𝘀 𝗠𝗲𝗱𝗶𝗰𝗶𝗻𝗲: Michael, an athlete with a torn ligament, saw accelerated healing with PDPA. "It was a game-changer for my recovery. I was back on the field much sooner than expected," he shares. 🏃♂️ 🚀 𝗧𝗵𝗲 𝗜𝗺𝗽𝗮𝗰𝘁 𝗼𝗳 𝗣𝗗𝗣𝗔: These case studies demonstrate PDPA’s potential to transform lives by promoting faster and more efficient healing. Its ability to differentiate into various cell types and regulate the immune response sets it apart from traditional treatments. Have you or someone you know experienced the benefits of PDPA? What are your thoughts on its potential to revolutionize arthritis treatment? Share your stories and engage with us! #RegenerativeMedicine #PDPA #MedicalInnovation #Healthcare #Biotechnology #ArthritisTreatment #Healing #PatientStories #AmericanArthritisFoundation #FutureOfMedicine

Examining miRNA packaging into small extracellular vesicles and its implications in pain: in this article, Jason DaCunza, Jason Wickman, Seena Ajit at Drexel University College of Medicine reviewed current insights into the targeting mechanisms of miRNAs into sEVs, focusing on the roles of RNA-binding proteins and EXOmotif sequences in miRNA loading. Studies on human pain disorders and rodent pain models have revealed notable changes in sEV cargo, including miRNAs https://lnkd.in/et2yYFpb Additionally, they offered a comprehensive overview of emerging therapeutic strategies for clinical sEV applications, highlighting areas of further research needed to optimise sEVs as effective treatments for pain management. #extracellularvesicles #exosomes #miRNA #pain #Vesiculab

Exciting to see the progress in injectable treatments for knee osteoarthritis! These advancements offer potential hope for improved pain relief and function, ultimately enhancing the quality of life for patients. Encouraging continued research in this field is crucial for developing even more effective therapies in the future. #Research #Osteoarthritis #PatientCare