Pharmacy Group Journals’ Post

https://lnkd.in/gAmYqQHS Article Title: In-silico analysis of tenidap and its derivative as a novel 5-lipoxygenase inhibitor Author(s): Asma Noor*, Ardas Masood, Jawaria Khan, Tanveer Abbas and Muhammad Imran Qadir Journal: International Journal of Pharmaceutical Sciences and Developmental Research Journal ISSN: 2640-7760 Abstract: Tenidap is a derivative of Flavonoids which are actually plant derivatives, it shows inhibition activity of 5-lipoxygenase. Molecular models were directed to discover molecular docking mode, also to help explain molecular tool behind its inhibitory action. Molecular relations of tenidap with the catalytic trio (His523, His518, Ile875) inside active or dynamic position of 5-lipoxygenase through hydrogen bonding, appears to the major reason elaborate in its substantial 5-lipoxygenase activity of inhibition. #Tenidap #5lipoxygenase #Antiinflammatoryeffect #Pharmacy #Pharmacology #PharmaceuticalSciences #ClinicalPharmacy #MedicinalChemistry #DrugDevelopment #Pharmacokinetics #Pharmacodynamics #Pharmacogenomics #Toxicology #Pharmaceutics #Biopharmaceutics #Pharmacognosy #PharmaceuticalChemistry #PharmacyPractice #CommunityPharmacy #HospitalPharmacy #IndustrialPharmacy #RegulatoryAffairs #DrugFormulation #DrugDelivery #PharmacyManagement #PharmaceuticalTechnology #PharmacyEducation #ClinicalTrials

https://lnkd.in/g2vQd34A Article Title: Validation of spectrophotometric method for determination of esomeprazole and ciprofloxacin in their pure and dosage forms Author(s): Mohsen M Zareh, Monir Z Saad, Wafaa S Hassan, Mostafa E Elhennawy and Mahmoud M Sebaiy* Journal: International Journal of Pharmaceutical Sciences and Developmental Research Journal ISSN: 2640-7760 Abstract: A novel simple, accurate, sensitive and economical spectrophotometric method has been established and validated for the determination of esomeprazole and ciprofloxacin. The method is based on the oxidation of the studied drug by a known excess of potassium permanganate, followed by measuring the decrease in absorption (∆A) of KMnO4 in acidic medium at wavelength of 525nm. The detection limit is reported to be 1.01 and 1.06µg/mL showing a high degree of sensitivity. The proposed method was successfully validated according to ICH guidelines for the determination of esomeprazole and ciprofloxacin with a highly precise recovery and very low relative standard deviation. Finally, the method was compared statistically with a reference method showing equal accuracy, reproducibility and no significant difference with the reported one. #Spectrophotometric #Esomeprazole #Ciprofloxacin #KMnO4 #ICHguidelines #MedicinalChemistry #DrugDevelopment #Pharmacokinetics #Pharmacodynamics #Pharmacogenomics #Toxicology #Pharmaceutics #Biopharmaceutics #Pharmacognosy #PharmaceuticalChemistry #PharmacyPractice #CommunityPharmacy #HospitalPharmacy #IndustrialPharmacy #RegulatoryAffairs #DrugFormulation #DrugDelivery #PharmacyManagement #PharmaceuticalTechnology #PharmacyEducation #ClinicalTrials

https://lnkd.in/gZZpfqdP Article Title: Regarding the measurement of therapeutic adherence Author(s): Sara Malo* Journal: International Journal of Pharmaceutical Sciences and Developmental Research Journal ISSN: 2640-7760 Adherence to chronic therapies among population living in developed countries has been estimated about 50% [1]. This is a matter of concern, since poor adherence is associated with suboptimal clinical outcomes, increased frequency of adverse effects and high healthcare expenses [2]. #MedicinalChemistry #DrugDevelopment #Pharmacokinetics #Pharmacodynamics #Pharmacogenomics #Toxicology #Pharmaceutics #Biopharmaceutics #Pharmacognosy #PharmaceuticalChemistry #PharmacyPractice #CommunityPharmacy #HospitalPharmacy #IndustrialPharmacy #RegulatoryAffairs #DrugFormulation#DrugDelivery #PharmacyManagement #PharmaceuticalTechnology #PharmacyEducation #ClinicalTrials

Hi Dear Professors, Researchers, and Students International Pharmacy Acta, is a journal that is interested in receiving your valuable manuscript to be published online. #pharmacology #pharmaceutical #toxicology #Pharmacogenomics #pharmaceuticalscience #pharmauticalchemistry #medicalchemistry #pharmacognosy #nanotechnology #ClinicalPharmacy #biotechnology #veterinarypharmacy #nuclear_pharmacy #pharmacoeconomy #pharmacycommunity

Hi Dear Professors, Researchers, and Students International Pharmacy Acta, is a journal that is interested in receiving your valuable manuscript to be published online. #pharmacology #pharmaceutical #toxicology #Pharmacogenomics #pharmaceuticalscience #pharmauticalchemistry #medicalchemistry #pharmacognosy #nanotechnology #ClinicalPharmacy #biotechnology #veterinarypharmacy #nuclear_pharmacy #pharmacoeconomy #pharmacycommunity

https://lnkd.in/gYqzuUA4 Article Title: Spray dried self-nanoemulsifying drug delivery systems for sertraline HCl: Pharmacokinetic study in healthy volunteers Author(s): Hussein O. Ammar, Mahmoud M. Ghorab, Dina M. Mostafa, and Amira M. Ghoneim* Journal: International Journal of Pharmaceutical Sciences and Developmental Research Journal ISSN: 2640-7760 Abstract: Purpose: The aim of this study is to improvelow oral bioavailability of sertraline HCl by formulation and characterization ofsolid self-nanoemulsifying drug delivery system [SNEDDS] using spray drying technique. Methods: Solubility of sertraline HCl in different vehicles was determined, and ternary phase diagrams were constructed.Various formulations were prepared and characterized by morphological characterization, differential scanning calorimetry and droplet size analysis. The formulations were evaluated for In vitro release profile in comparison to the marketed product [Lustral® tablets]. The In vivo study was performed on healthy human volunteers for pharmacokinetic analysis of the optimized formulations. #SertralineHCl #Spraydrying #SelfNanoemulsifying #ReleaseBioavailability #Pharmacokinetics #Antidepressives #Pharmacy #Pharmacology #PharmaceuticalSciences #ClinicalPharmacy #MedicinalChemistry #DrugDevelopment #Pharmacokinetics #Pharmacodynamics #Pharmacogenomics #Toxicology #Pharmaceutics #Biopharmaceutics #Pharmacognosy #PharmaceuticalChemistry #PharmacyPractice #CommunityPharmacy #HospitalPharmacy #IndustrialPharmacy #RegulatoryAffairs #DrugFormulation #DrugDelivery #PharmacyManagement #PharmaceuticalTechnology #PharmacyEducation #ClinicalTrials

The market for highly potent active pharmaceutical ingredients (HPAPIs) is estimated to reach USD $31.5 billion by 2029. HPAPIs require numerous considerations, including potency categorization, engineering controls, and global regulatory requirements. Gain a better understanding of the manufacturing process as we tackle these considerations and more in Issue 35 of The Altascientist: https://lnkd.in/dGwr4rN3 #DrugDevelopment #Toxicology #Pharmacology

https://lnkd.in/ghNjFCHj Article Title: Visible light and UV-assisted photodegradation of phenylephrine by bulk NiO and NiO immobilized on magnetic polypyrrole support Author(s): Hossein Faghihian and Firoozeh Torki* Journal: International Journal of Pharmaceutical Sciences and Developmental Research Journal ISSN: 2640-7760 Abstract: The nanophotocatalysts; NiO and NiO immobilized on the surface of magnetized polypyrrole (NiO-PPY-Fe3O4) were synthesized and used for photodegradation of phenylephrine. The synthesized photocatalysts were characterized by FTIR, TG, XRD, BET, VSM, TEM and SEM techniques. Diffuse reflectance spectroscopy was used to measure the band gap nergy of the synthesized photocatalyst. Photoluminescence analysis was employed to estimate the electron-hole recombination. #Phenylephrine #Magneticsupport #Polypyrrole #Visiblelightdegradation #MedicinalChemistry #DrugDevelopment #Pharmacokinetics #Pharmacodynamics #Pharmacogenomics #Toxicology #Pharmaceutics #Biopharmaceutics #Pharmacognosy #PharmaceuticalChemistry #PharmacyPractice #CommunityPharmacy #HospitalPharmacy #IndustrialPharmacy #RegulatoryAffairs #DrugFormulation #DrugDelivery #PharmacyManagement #PharmaceuticalTechnology #PharmacyEducation #ClinicalTrials

Did you know that more than 90% of drugs being developed never make it to the shelves of the pharmacy or market? 40% of these failures can be attributed to non-clinical toxicity. Over the next decade of small molecule drug development, this means that 8000 compounds will fail due to non-clinical toxicity alone. Did you know that non-clinical toxicity is often linked to high lipophilicity of compounds? And did you know that lipophilicity is simply the ratio of the solubility in a lipidic environment vs. the solubility in an aqueous environment which can be readily measured? Even a 1% decrease in attrition due to non-clinical toxicity over the next decade would mean savings for global pharmaceutical R&D of 77 billion US dollars, an amount that would be enough to bring 26 new drugs to the market. Today, it is possible to accurately measure solubility from micrograms of material, why would you not? #solubility #lipophilicity #logP #drugdiscovery #drugdevelopment #failfast ##nonclinicaltoxicology #toxicology #drugattrition #physicochemical #cro

Pharmaceutical manufacturers need to ensure the safety of their products. Part of this process is developing a Technically Unavoidable Particle profile (TUPP). SAXOCON can help you design your TUPP to communicate your expectations clearly to your materials suppliers. Read more about TUPPs here: https://lnkd.in/d_uaZizK #Toxicology #Pharmaceuticals #BioSafety