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𝗟𝗲𝘁’𝘀 𝘀𝗰𝗿𝗮𝘁𝗰𝗵 𝘆𝗼𝘂𝗿 𝗱𝗿𝘂𝗴 𝗱𝗶𝘀𝗰𝗼𝘃𝗲𝗿𝘆 𝗰𝗮𝗽 𝗮𝗻𝗱 𝘀𝘁𝗮𝘆 𝗮𝗵𝗲𝗮𝗱 𝘄𝗶𝘁𝗵 PharmaVantage Global! We’re launching this platform just for YOU, bringing you the latest insights and cutting-edge information to keep you at the forefront of pharma. We’re kicking things off with an incredible 𝘁𝗲𝗰𝗵𝗻𝗶𝗾𝘂𝗲 𝗳𝗼𝗿 𝗮𝗳𝗳𝗶𝗻𝗶𝘁𝘆 𝗺𝗲𝗮𝘀𝘂𝗿𝗲𝗺𝗲𝗻𝘁, a must-know method in the industry. Get ready to explore, learn, and lead with us! 🔬 𝗦𝘂𝗿𝗳𝗮𝗰𝗲 𝗣𝗹𝗮𝘀𝗺𝗼𝗻 𝗥𝗲𝘀𝗼𝗻𝗮𝗻𝗰𝗲 (𝗦𝗣𝗥) If you're involved in drug discovery, understanding molecular interactions is essential—and 𝗦𝘂𝗿𝗳𝗮𝗰𝗲 𝗣𝗹𝗮𝘀𝗺𝗼𝗻 𝗥𝗲𝘀𝗼𝗻𝗮𝗻𝗰𝗲 (𝗦𝗣𝗥) is one of the most effective tools for this. But what exactly makes SPR so valuable, and why should 𝗽𝗿𝗼𝘁𝗲𝗶𝗻 𝗲𝗻𝗴𝗶𝗻𝗲𝗲𝗿𝘀 in drug discovery, including 𝗰𝗼𝗺𝗽𝘂𝘁𝗮𝘁𝗶𝗼𝗻𝗮𝗹 𝗯𝗶𝗼𝗹𝗼𝗴𝗶𝘀𝘁𝘀, be well-versed in its application? 🌟 𝗛𝗼𝘄 𝗦𝗣𝗥 𝗪𝗼𝗿𝗸𝘀 In a typical SPR experiment, one interaction partner (such as a protein) is immobilized on a sensor chip, while the other molecule (such as a drug candidate) flows over the chip in solution. When they interact, the refractive index near the sensor surface changes, generating a 𝘀𝘂𝗿𝗳𝗮𝗰𝗲 𝗽𝗹𝗮𝘀𝗺𝗼𝗻 𝘄𝗮𝘃𝗲. This shift is detected in real-time and provides detailed kinetic and affinity data. 🌟 𝗪𝗵𝘆 𝗦𝗣𝗥 𝗠𝗮𝘁𝘁𝗲𝗿𝘀 𝗶𝗻 𝗗𝗿𝘂𝗴 𝗗𝗶𝘀𝗰𝗼𝘃𝗲𝗿𝘆 Drug development revolves around understanding how potential drug molecules interact with their biological targets. 𝗦𝗣𝗥 provides 𝗿𝗲𝗮𝗹-𝘁𝗶𝗺𝗲, 𝗹𝗮𝗯𝗲𝗹-𝗳𝗿𝗲𝗲 𝗱𝗮𝘁𝗮 on these molecular interactions, allowing researchers to observe binding events without modifying the molecules. SPR gives researchers detailed insights into both 𝗸𝗶𝗻𝗲𝘁𝗶𝗰𝘀 𝗮𝗻𝗱 𝗮𝗳𝗳𝗶𝗻𝗶𝘁𝘆. Kinetics reveals how quickly and strongly a drug binds to its target, as well as how long it stays bound. The 𝗮𝘀𝘀𝗼𝗰𝗶𝗮𝘁𝗶𝗼𝗻 𝗿𝗮𝘁𝗲 (𝗞𝗼𝗻) and 𝗱𝗶𝘀𝘀𝗼𝗰𝗶𝗮𝘁𝗶𝗼𝗻 𝗿𝗮𝘁𝗲 (𝗞𝗼𝗳𝗳) are critical in evaluating drug efficacy in a biological system. 🌟 𝗪𝗵𝘆 𝗖𝗼𝗺𝗽𝘂𝘁𝗮𝘁𝗶𝗼𝗻𝗮𝗹 𝗕𝗶𝗼𝗹𝗼𝗴𝗶𝘀𝘁𝘀 𝗦𝗵𝗼𝘂𝗹𝗱 𝗨𝗻𝗱𝗲𝗿𝘀𝘁𝗮𝗻𝗱 𝗞𝗶𝗻𝗲𝘁𝗶𝗰𝘀 𝗗𝗮𝘁𝗮 While SPR may seem like a technique rooted in experimental biophysics, it holds great value for computational biologists, who often work on 𝗽𝗿𝗲𝗱𝗶𝗰𝘁𝗶𝗻𝗴 𝗺𝗼𝗹𝗲𝗰𝘂𝗹𝗮𝗿 𝗶𝗻𝘁𝗲𝗿𝗮𝗰𝘁𝗶𝗼𝗻𝘀 using popular methods like 𝗺𝗼𝗹𝗲𝗰𝘂𝗹𝗮𝗿 𝗱𝗼𝗰𝗸𝗶𝗻𝗴 𝗮𝗻𝗱 𝗺𝗼𝗹𝗲𝗰𝘂𝗹𝗮𝗿 𝗱𝘆𝗻𝗮𝗺𝗶𝗰𝘀 𝘀𝗶𝗺𝘂𝗹𝗮𝘁𝗶𝗼𝗻𝘀 to estimate how molecules interact at an atomic level. By comparing experimental SPR data with 𝘪𝘯 𝘴𝘪𝘭𝘪𝘤𝘰 predictions, computational biologists can fine-tune their simulations to better mimic real-world interactions. This feedback loop between experimental data and computational predictions provides stronger guidance for drug design efforts. 💭𝘚𝘩𝘢𝘳𝘦 𝘺𝘰𝘶𝘳 𝘵𝘩𝘰𝘶𝘨𝘩𝘵𝘴! #SPR #drugdiscovery #proteinengineering #pharmavantageglobal

Meet us at Discovery Europe 2024 to discuss your future projects in the realm of:   ✅ Medicinal Chemistry: TCGLS excels in the design and synthesis of innovative chemical compounds possessing properties conducive to drug development. ✅ Discovery biology: This includes a wide range of offerings such as high-throughput screening (HTS), assay development, both in vitro and in vivo pharmacology studies, target validation, and the discovery of biomarkers. ✅ Chemical Biology: TCGLS employs chemical tools adeptly to explore biological systems and drug targets, thereby enhancing the understanding of complex biochemical interactions. ✅ Computational Chemistry: Leveraging in-house developed computational tools and algorithms. TCGLS engages in CADD, virtual screening, and molecular modelling to expedite the drug discovery process. ✅ Analytical Services: We provide comprehensive analytical chemistry services including method development and validation, impurity identification, and elucidation of molecular structures. ✅ Preclinical Development: We offer early-stage drug development services encompassing pharmacokinetic (PK) studies and toxicology assessments essential for evaluating the safety and efficacy of potential drug candidates.   ✅ Bioinformatics: Through cutting-edge analysis of biological data including genomics, transcriptomics & proteomics, TCGLS aids in unravelling unique biological mechanisms, via integration of informatics & biology, crucial for drug discovery in a therapeutic area agnostic manner. ✅Therapeutic Focus: TCGLS specializes in providing targeted solutions across a spectrum of therapeutic areas. Their expertise extends to Inflammation & Pain management, Infectious Diseases, Central Nervous System disorders, and Oncology. #medicinalchemistry #chemicalbiology #preclinicaldevelopment #analyticalservices #drugresearchanddevelopment #pharmaceuticals #medicalresearch #pharmaceuticalindustry #tcgls #biotechnology #teamtcgls

We are seeking a highly skilled Senior Research Scientist to join our team. The ideal candidate will have extensive experience in 2D & 3D cell culture systems, bioassay method development, and a broad range of assay techniques, including ELISA, cell-based assays, and advanced technologies such as TR-FRET and SPR. This role involves developing and optimizing experimental protocols, analyzing data, and contributing to novel research initiatives. Key Responsibilities: Cell Culture: - 2D & 3D Cultures: Develop and maintain 2D and 3D cell culture models, including spheroids, to study cellular behavior and drug responses. - Cell Line Management: Culture and characterize various cell lines, including primary cells and immortalized lines. Bioassay Method Development: - Design and optimize ELISA, TR-FRET and AlphaLISA assays for quantitative and qualitative analysis of biomolecules. - Cell-Based Assays: Develop and validate assays such as ADCC, CDC, cytotoxicity assays, PBMC co-culture assays, reporter based assay. Biophysical Assays: - SPR & OCTET: Implement and optimize Surface Plasmon Resonance (SPR) and Octet assays for biomolecular interactions and characterization. Qualification & Validation: - Assay Qualification: Perform assay qualification and validation to ensure accuracy, reliability, and reproducibility of experimental results. - ADME Assays: Experience with ADME assays is a plus. Qualifications: - Education: Bachelor’s or Master’s degree in Cell Biology, Biochemistry, Molecular Biology, or related field. - Experience: Minimum 5 years of experience with 2D & 3D cell cultures, bioassay development, and advanced assay techniques. - Technical Skills: Proficiency in ELISA, cell-based assays (ADCC, CDC, cytotoxicity), PBMC co-culture assays, TR-FRET, AlphaLISA, SPR, and OCTET. - Analytical Skills: Strong ability to interpret complex data and draw actionable conclusions. - Communication: Excellent verbal and written communication for report preparation and presentations. - Team Collaboration: Proven effectiveness in team environments and mentoring junior scientists. - Attention to Detail: High commitment to accuracy and precision. Desired Qualities: - Problem-Solving: Strong, proactive approach to technical challenges. Innovative Thinking: Critical and creative thinking to develop new methodologies. - Time Management: Ability to manage multiple projects and meet deadlines. - Adaptability: Flexibility in adjusting to changing priorities and project requirements. What We Offer: - Competitive salary and benefits - Professional development and career growth - Dynamic, inclusive work environment - Access to cutting-edge research facilities and technology Application Process: Submit your resume, cover letter, and three references to career@vipragen.com or visit our website at www.vipragen.com for more details. #hiring #Careers #CareerOpportunity #JoinOurTeam #VipragenBiosciences #JobOpening #bioassay #discovery #biology #cellculture

Scaffold Hopping Greetings, fellow researchers 😁, Today, we'll explore Scaffold Hopping, a vital technique in drug discovery for identifying new chemical scaffolds with desired biological activities. Understanding Scaffold Hopping Scaffold hopping refers to the process of identifying new chemical structures (scaffolds) that retain the biological activity of known compounds but differ in their core framework. This technique is essential for discovering novel drug candidates and circumventing issues such as patent barriers, toxicity, and resistance. Key Concepts 1. Scaffold Definition: - Definition: The core structure of a molecule that is responsible for its biological activity. - Example: A benzene ring or a pyridine ring. 2. Bioisosteres: - Definition: Functional groups or atoms that can be replaced by another with similar physical or chemical properties to retain biological activity. - Example: Replacing a carboxyl group (-COOH) with a tetrazole ring. 3. Chemoinformatics: - Role: Utilizes computational tools and databases to identify potential scaffolds. - Example: Using software to search chemical databases for bioisosteric replacements. Applications 1. Overcoming Patent Barriers: - Role: Identifies novel scaffolds that can be patented, avoiding existing patents. - Example: Discovering a new core structure for an antihypertensive drug to bypass patent restrictions. 2. Improving Drug Properties: - Role: Enhances drug properties such as solubility, bioavailability, and toxicity. - Example: Modifying the scaffold of an antibiotic to reduce side effects and improve efficacy. 3. Addressing Drug Resistance: - Role: Identifies new scaffolds to overcome resistance mechanisms in pathogens or cancer cells. - Example: Developing new antifungal agents with different scaffolds to tackle resistant strains. Challenges and Future Directions 1. Complexity of Chemical Space: - Challenge: The vastness of chemical space makes identifying suitable scaffolds difficult. - Future Direction: Advanced algorithms and AI to efficiently navigate and identify novel scaffolds. 2. Validation of Biological Activity: - Challenge: Ensuring new scaffolds retain or improve biological activity. - Future Direction: Combining scaffold hopping with high-throughput screening for rapid validation. 3. Integration with Experimental Data: - Challenge: Bridging computational predictions with experimental verification. - Future Direction: Enhanced integration of in silico and in vitro techniques for more reliable results. Scaffold hopping is a powerful tool in drug discovery, enabling researchers to identify novel scaffolds with desired biological activities while overcoming patent barriers and improving drug properties. Thank you for joining me in exploring the intricacies of Scaffold Hopping. Stay tuned for more insights into pharmaceutical research advancements. Warm regards, Diovu Charles

#hiring Principal Scientist, Small Molecule Assay Development, San Francisco, United States, fulltime #jobs #jobseekers #careers #SanFranciscojobs #Californiajobs #ScienceTechnology Apply: https://lnkd.in/gg4C2S2A Principal Scientist, Small Molecule Assay Development About Rezo Therapeutics Rezo is a different kind of biopharma company. Our mission is to dramatically increase the success rate of drug development by building a disease-agnostic, fully-integrated, network biology platform that will redefine our understanding of human disease and ability to treat it. Our Founders and members of the Board are a group of esteemed, world-class scientists from the University of California, San Francisco: Nevan Krogan, Kevan Shokat, Sourav Bandyopadhyay, Natalia Jura, as well as renowned biotech executives George Scangos and Norbert Bischofberger. These leaders bring with them a strong track record of amazing discoveries and scientific breakthroughs, leading to very successful companies and many FDA approved drugs. Capitalizing on our Series A of $78M from top-tier investors, we are leveraging a unique integrated approach, combining capabilities in genetics, proteomics, structural biology and AI to generate deep biological insights and novel therapeutic approaches. Located in San Francisco's vibrant Mission Bay neighborhood, Rezo is in close proximity to UCSF, numerous urban amenities, and outdoor recreational opportunities. We recognize that realizing our mission depends as much on our people as it does on our science and are building a workplace that fosters collaboration, respect, and diversity where contributing to your team's success is valued as highly as individual achievements. If you're passionate about team science and breaking down barriers to progress in drug development, please consider joining us! The Opportunity We are seeking a highly enthusiastic and motivated Principal Scientist to join our Discovery Biology team. This role will be responsible for the design and execution of biochemical and biophysical assays of small molecule protein targets. Becoming a member of this team is an excellent opportunity to join Rezo at an early stage and help build the Discovery Biology function and the company from the ground up. What You'll Do: Establish and implement expression strategies and support reagent generation to enable HTP screening and biophysical characterization of multiple protein targetsDesign and oversee diverse, robust, and reproducible biochemical and biophysical assays across all phases of discovery and developmentExplore and evaluate new technologies related to Protein Sciences, and contribute to long-term activity planningPartner with Platform, Discovery Biology, Chemistry, and other departments to drive drug discovery efforts forwardManage and analyze experimental data, interpret results, and prepare necessary materials fo

Focus on immunotherapy, including personalized neoantigen approaches and expand development of Merck’s oncology pipeline! This is an opportunity to: • Analyze, visualize and summarize NGS and other molecular data from oncology clinical trials and proprietary and public large molecular databases, including bulk tissue nucleotide acid sequencing and periphery comprehensive molecular assays including TCR sequencing, protein profiling, immune activation assays, and liquid biopsies. • Leverage AI/ML (e.g. classification and regression algorithms) and integrative analytic methods to investigate proprietary and public immunogenomic datasets in conjunction with tissue and periphery assays with the goal of improving the detection and utilization of patient-specific neoantigens. • Use oncology molecular data to identify biomarkers and molecularly defined groups of patients as well as molecular mechanisms of modulation of therapeutic response reflected in longitudinal analytes, with a focus on identifying novel targets matched to groups of cancer patients with unmet medical need. Apply direct through link below. #ngs #oncology #pharma #ai #ml #biomarkers #tcr #proteinprofiling #liquidbiopsy #immunotherapy #immunotherapies #clinicaldata #clinicalresearch #researchanddevelopment #neoantigen #computerscience #computationalbiology #datascience #datascienced #stem #phd #appliedmath #pharmajobs #pharmaceutical #pharmaceuticals #lifesciences #likeandshare https://lnkd.in/eXKZuR39

Advance your career at AstraZeneca, #cambridge UK as a #senior #scientist - #Protein Engineer in our #biologicsengineering team. This pivotal role involves isolating, optimising, and engineering #antibodies, #antibody fragments, and single domain #antibodies for our #therapeutic programmes. Utilise a variety of in vitro display platforms, such as phage, mammalian, RNA, and ribosome display, to drive innovation and support technological development within our Protein Engineering & Novel Modalities group. #joinus in our mission to push the boundaries of #science and make a difference in the world of #medicines. #biologics #followthescience #innovation #jobsearch #newcareeropportunities #sciencejobs #groundbreaking #lovewhatyoudo #greatplacetowork #greatplacetowork2023

🚀 Exciting News! 🚀 We're thrilled to announce the publication of our latest article in Frontiers in Pharmacology: "Life Scientists Improve QSP Model Quality and Impact." This work highlights the pivotal role life scientists play in enhancing the biological relevance and quality of QSP models, ensuring better decision-making in drug development. 🔗 Read the full article here: https://buff.ly/3W8l1Mo We'd love to hear your thoughts and experiences. How have life scientists influenced your work with QSP models? Share your stories in the comments! 👇 #QSP #Pharmacology #DrugDevelopment #LifeScience

X-Ray Crystallography Services Market Opportunities, Segmentation, Assessment and Competitive Strategies by 2033 https://lnkd.in/daaTEzue The X-Ray Crystallography Services Market is experiencing steady growth propelled by the increasing demand for structural biology research and drug discovery applications. This market report provides a comprehensive overview of the global landscape, covering key players, market trends, growth drivers, challenges, and opportunities. X-ray crystallography services play a crucial role in determining the three-dimensional structure of molecules, proteins, and crystalline materials, enabling insights into their atomic and molecular arrangement. The report explores various segments such as protein crystallography, small molecule crystallography, macromolecular crystallography, and geographic regions, providing insights into market dynamics and competitive strategies. Additionally, factors such as technological advancements in X-ray diffraction instruments, the increasing outsourcing of structural biology research by pharmaceutical and biotechnology companies, and the growing focus on personalized medicine are discussed, reflecting the evolving landscape and its impact on market growth. Moreover, the report examines emerging trends such as the use of synchrotron radiation facilities for high-resolution crystallography studies and the integration of computational methods for structure determination. Overall, the X-Ray Crystallography Services Market report equips stakeholders, investors, and industry participants with actionable insights to navigate the evolving landscape and capitalize on emerging opportunities in this vital sector, facilitating advancements in drug discovery, materials science, and structural biology research. Market Drivers: Drug Discovery and Development: X-ray crystallography services play a crucial role in drug discovery and development by providing detailed structural information about target molecules, protein-ligand complexes, and drug candidates. This enables pharmaceutical companies to optimize drug designs, assess binding interactions, and accelerate the drug development process. Biological Research: X-ray crystallography services are extensively used in biological research for elucidating the three-dimensional structures of biomolecules, such as enzymes, receptors, and antibodies. Understanding these structures is essential for deciphering biological functions, disease mechanisms, and molecular interactions, leading to advances in basic science and medical research. Material Characterization: In materials science and engineering, X-ray crystallography services are employed for characterizing the atomic and molecular structures of crystalline materials, polymers, ceramics, and nanoparticles. This facilitates the development of new materials with tailored properties for various applications, including electronics, aerospace, and energy s