Rapid Fluidics’ Post

Learn more about my lab’s out-of-this-world research! Stem cells in space🧫🚀 Thanks to Dr Zubair and all the different teams involved!

This International Women's Day, we are celebrating the work of Women in Ophthalmology, not just at home but abroad. Special shout out to Dr Hema Ramkumar MD in the US, who is leading an "out-of-this-world" study on macular degeneration in space. "This will be a groundbreaking study involving the first retinal photos after spaceflight, the first gene therapy study in space, the first ophthalmic treatment study on live animals in space, and the first study involving an all-female mouse team (previous studies only used male mice). "Beyond age-related macular degeneration, this project may shed light on the effect of spaceflight on the retina, as well as unravel the potential to enhance our ability to combat the stressors of spaceflight — topics NASA is very interested in as it continues to pioneer human space exploration." Read more about the "out-of-this-world" study 👉 https://buff.ly/3SSIa2z American Academy of Ophthalmology NASA - National Aeronautics and Space Administration #ophthalmology #maculardegeneration #WomeninOphthalmology #WIO #InternationalWomensDay #IWD #InspireInclusion

As most of you know by now, my team and I have conducted a comprehensive study on the impact of #space environments on gene expression, with a focus on those involved in blood 🩸 homeostasis and hemoglobin production. Our #research highlights the significant alterations in gene 🧬 activity related to erythropoiesis, particularly in the production of globin chains, under space conditions. Utilizing multi-omic datasets from NASA GeneLab , including the NASA - National Aeronautics and Space Administration Twins Study, the JAXA: Japan Aerospace Exploration Agency CFE study, and the SpaceX Inspiration4 mission, Josef Borg et al examined the developmental expression of hemoglobin over various temporal and spatial contexts. Our findings reveal notable variations in globin gene expression corresponding to the unique characteristics of the space environment. This study underscores the dynamic nature of gene regulation in space and provides valuable insights into the broader implications of space omics research. We hope that this research provides crucial insights for advancing our understanding of human health during space missions and to contribute significantly to the field of space biology 🧫 Now watch our next blood research work as part of the #spacex Polaris Dawn launch 🚀!! See the full text article right here published under SOMA -> https://lnkd.in/eMQNa3fb

👨🚀 Spacetech and digital health   A solicitation recently published by the International Space Station National Laboratory and NASA - National Aeronautics and Space Administration is offering up to $4M for “projects that leverage space environment and technology to develop therapies for diseases on Earth”.   🔎 According to the ISS National Lab announcement, the call focuses on “projects that utilize microgravity and the unique space environment to address challenges that hinder the progress in preventing, diagnosing, and treating some of the most significant diseases of our time”, such as cancer, cardiovascular, immune, muscle and bone, and neurodegenerative diseases.   Some topics of relevance from the call: 🖥 Enhanced Models to Study Disease Mechanisms 📊 Population and Disease Heterogeneity 💊 Drug Screening and Development 💉 Drug Delivery 🔬 Drug Resistance and Toxicity   To health and beyond! 📌 Check it out with sources in first comment   #spacetech #digitalhealth

The impairment of the central nervous system (CNS) poses a significant health risk for astronauts 🧑🚀 on long-duration #space missions. A recent study carried out by Sylvain Costes and Stefania Giacomello and other scientists utilized an innovative approach by integrating single-cell multiomics (transcriptomics and chromatin accessibility) with spatial transcriptomics to investigate the impact of spaceflight 🚀 on the brains of female mice 🐭 . Comparative analysis between ground control and spaceflight-exposed animals revealed substantial alterations in critical brain processes, including neurogenesis, synaptogenesis, and synaptic transmission, particularly in the cortex, hippocampus, striatum, and neuroendocrine structures 😮 Additionally, they observed astrocyte activation and signs of immune dysfunction. At the pathway level, some spaceflight-induced changes in the brain 🧠 exhibited similarities with neurodegenerative disorders, marked by oxidative stress and protein misfolding. Their integrated spatial multiomics approach offers valuable insights into spaceflight-induced CNS impairments at the level of individual brain regions and cell types, providing a foundation for future research. For broader scientific impact, all datasets from this study are accessible via an interactive data portal and the NASA Open Science Data Repository (OSDR). Please check the full text article published under SOMA right here -> https://lnkd.in/egKiAEep NASA GeneLab Jonathan Galazka Egle Cekanaviciute Springer Nature Group Nature Portfolio

NASA's Top Station Science News: August 9, 2024 Highlights Groundbreaking Research in Space: Enhancing Health and Manufacturing for Future Missions In a recent study, researchers explored a novel treatment on cartilage and bone tissue cultures subjected to compressive impact injury. The study revealed intriguing differences in the metabolites and proteins released by cells in space compared to those on Earth, alongside partial improvements in both gravity conditions. These findings suggest that the treatment is safe and has the potential to enhance the health of astronauts on future missions, as well as patients on Earth. Musculoskeletal injuries are common among astronauts, and joint injuries leading to post-traumatic osteoarthritis are a […] https://lnkd.in/dUe2VUSg https://lnkd.in/dqQx3wWU

📢 PROVE Network Unveils New Website - https://lnkd.in/gwBcty7c 📝 Explore a comprehensive body of research created by the PROtective VEntilatoon (PROVE) Network, comprising 21 RCTs and 12 observational studies in ventilation, along with insights from 4 harmonized and pooled databases; delve into 8 studies on closed–loop ventilation, examine findings from 4 Delphi consensus processes covering various aspects of respiratory support, and stay informed on 3 large–scale COVID–19 projects... #PROVENetwork #VentilationResearch #LungProtectiveVentilation #IntensiveCareUnit #ICU #OperatingRoom #OR #Draeger

The SpaceX Inspiration4 mission presented a unique opportunity to study the effects of spaceflight on the human body. Throughout 2021 and 2022, biospecimen samples were collected from four crew members (Jared Isaacman, Chris Sembroski Sian “Leo” Proctor, Ph.D. And Hayley Arceneaux) at multiple time points: pre-flight (L-92, L-44, L-3 days), during the flight (FD1, FD2, FD3), and post-flight (R + 1, R + 45, R + 82, R + 194 days), encompassing a total of 289 days. The comprehensive collection included venous whole blood, capillary dried blood spot cards, saliva, urine, stool, body swabs, capsule swabs, SpaceX Dragon capsule HEPA filter, and skin biopsies 😮 Venous whole blood was further processed to obtain serum, plasma, extracellular vesicles and particles, and peripheral blood mononuclear cells. Overall, 2,911 sample aliquots were sent to Weill Cornell Medicine for advanced analysis and biobanking led by Christopher Mason and his colleagues , Eliah Overbey JangKeun Kim Krista Ryon Braden Tierney just to name a few that I know 😊 This study provided an extensive overview of the biospecimen collection process and highlights the advanced processing and long-term storage techniques used. It establishes a robust framework for collecting and preserving high-quality human, microbial, and environmental samples, which is critical for the Space Omics and Medical Atlas (SOMA) initiative. This research significantly contributes to our understanding of human spaceflight and supports future space biology experiments planned ahead. For the full text article under SOMA please see https://lnkd.in/d4spUNvr Photo: #spacex dragon capsule docked to the International Space Station NASA - National Aeronautics and Space Administration NASA GeneLab Spaceomix

SPACE MEDICINE AND UKTRA DEEP SPACE FLIGHT: Moody Active Denial Space Systems -360 Strategic Lunar Infrastructure is working with Pacific Joint Space Facility Pty Ltd and Moody Scientific-Global on Space Medicine and Ultra Deep Space Applications. #ultradeepspaceexploration #spacemedicine #rnamanipulation #syntheticbiology #nasa #pacificjointspacefacility #geneticmanipulation #humanbiology #Telemores #cellularexpression #johnmoody #nextgenerationleaders #moodyscientificglobal #geneediting #quantumscience #crossstructurecontrol #cellularmanipulationandcontrol

Learn how the #ProteographXT with Thermo Fisher Scientific's #OrbitrapAstralMS is enabling better understanding of astronaut responses to spaceflight and #proteome changes during organ transplantation and providing a versatile platform for model organism studies! Seer is collaborating with industry leaders to facilitate better access to unbiased, deep #proteomics at scale so you can add new dimensions to your research. The Seer Technology Access Center is one way we're doing it. #STAC serves studies from smaller proof of principal to standard full-service to #ProteographXT with MS, and, here, Aaron Gajadhar, PhD, highlights a few collaboration projects showcasing the enhanced characterization and insights being achieved. 🙌 #innovation #healthcare #pharma #biomarkers #proteomicsresearch #scienceandtechnology #improvinghumanhealth #teamwork