Rebecca de Wardt’s Post

RNA 5-methylcytosine marks mitochondrial double-stranded RNAs for degradation and cytosolic release: Molecular Cell https://lnkd.in/g88AF3Mx

What if your thalassemia workflow took hours instead of days? Discover how Next-Generation Sequencing (NGS) can overcome the challenges of modern transforming thalassemia testing in our new whitepaper, "Meeting Modern Demands: Overcoming Thalassemia Testing Challenges with NGS." 📥 Download now! https://bit.ly/3WtvTVm #NGS #Thalassemia #GeneticTesting #HealthcareInnovation #MedicalResearch

Assessing levels of circulating free and EV-associated nucleic acids in the plasma of glioblastoma patients: in their latest work, Elisabeth Rackles, Juan Manuel Falcon Perez at CIC bioGUNE and collaborators reported a straightforward and reproducible method to analyse cell-free nucleic acids in plasma and EVs using conventional flow cytometry, which can be easily translated into clinical practice https://lnkd.in/e-P587k3 They demonstrated that Pyronin Y-fluorescent staining of EVs isolated from cell-conditioned media is an effective method for detecting DNA and RNA using flow cytometry. An article co-authored by Elena Zaccheroni, Patricia Hernández López, Stefania Faletti, Massimiliano Del Bene, Francesco DiMeco and Giuliana Pelicci #extracellularvesicles #exosomes #glioblastoma #RNA #flowcytometry #Vesiculab

Are phage libraries representative of the background B cell repertoire? We answer this question using our NGS-powered #antibody repertoire sequencing and analysis platform, Reptor. Find the answer in our most recent blog post, where we compare a VHH phage library to direct B cell sequencing from an immunized llama. https://lnkd.in/gQkk2jUY #antibodysequencing #antibodydiscovery

Back to Basic: Determination of the numbers of reticulocytes or immature, non-nucleated RBCs that still contain RNA provides useful information about the capacity of the bone marrow to synthesize and release red cells in response to anemia and helps to distinguish between decreased RBC production and enhanced peripheral destruction. Corrected reticulocyte counts or the reticulocyte production index (RPI) can be used to compare the magnitude of reticulocytosis with the magnitude of anemia to determine whether the bone marrow response is adequate. #Ahmed_MLT_Sudan

Check out this new app note highlighting the performance of our Watchmaker RNA Library Prep Kit with Polaris Depletion on the Beckman Coulter Life Sciences Biomek i7 Hybrid NGS Workstation https://lnkd.in/gQRa_nP9 ✅ Generate 96 RNA libraries in under 8 hours ✅ Use RNA inputs as low as 1 ng ✅ Achieve excellent performance with FFPE samples What more could you ask for?? #AutoMagic #NGS #Genomics

In search of critical #dsRNA targets of #ADAR1 The role of denosine-to-inosine #RNAediting by ADAR in suppressing innate immune interferon responses triggered by cellular double-stranded RNA (dsRNA). However, transcriptome-wide analyses of ADAR editing patterns, as well as a study of the evolutionary dynamics of dsRNAs, suggest that the vast majority of ADAR targets are not immunogenic, or at least do not necessarily lead to an interferon response, even in their unedited form. https://lnkd.in/d55jESY8

Starting a new project that might need sequencing? I have availability next week for a free 30-minute consultation to chat about your project and explore the tailored sequencing services offered by Novogene America. Whether you require WGS, WES, mRNA seq, scRNA seq, metabolomics, metagenomics, or just want to know more about NGS, we've got the expertise and services to meet your sequencing needs. #NGS #nextgenerationsequencing #genomics #omics

The International Journal of Cell Biology and Cellular Function invites submissions for its upcoming issues. Share your research and contribute to advancing our understanding of cellular processes. Submit your manuscripts today! #Generalizedtransduction, #cellmembrane, #Mitochondria, #Reproductivecells, #CellCommunication, #Cellsignaling #GeneExpression #Signaltransduction #GProteinCoupledReceptors, #CellDisruption #yeastcell, #Cellcycle, #SNPs, #Geneticdisorder, #Immunoreceptors, #CalciumbindingProteins, #DNA, #RNA, #Proteins, #DNAdamage, #Celldeath, #oncogenes, #animalgenes, #plantcell, #bacteria, #fungi, #cell, #eukaryotes, #prokaryoticcell