Renal & Urology News’ Post

An analysis of Tafamidis in Transthyretin Cardiomyopathy Clinical Trial found tafamidis 80 mg, compared w/ placebo, attenuated the decline in left ventricular systolic & diastolic function in patients w/ transthyretin amyloid cardiomyopathy over 30 mos. https://ja.ma/3ScPve9

From the PAD Topic Center: BEST-CLI Research Team - Revascularization Enhances Quality of Life for Patients With Chronic Limb-Threatening Ischemia https://okt.to/60rSBg

Smart Research Review: Clinical Reasoning Behind Non-Pharmacological Interventions for the Management of Headaches “Migraine and tension-type headache (TTH) are the most prevalent primary headaches, whereas cervicogenic headache is the most prevalent secondary headache.” “...spinal manipulation was equally effective as some medication in the prophylactic management of migraine.” “This evidence supports the effectiveness of non-pharmacological manual therapy interventions for the treatment of headache...The most recent meta-analysis has pointed out that spinal manipulation may be effective for reducing the number of migraine days and the intensity of migraines.” https://bit.ly/3THU8hg

In the realm of healthcare, breakthroughs are crucial for tackling severe conditions like septic shock. Vivacelle Bio, Inc. is revolutionizing this space with innovative strategies highlighted in a recent interview with Harven DeShield, PhD, JD, MSc. Here are the key insights: - VivaCell's treatment approaches aim to enhance patient outcomes in septic shock care. - The focus is on improving cellular health to combat sepsis's severe impacts. - The company is leading with new methods that could potentially lower mortality rates linked to septic shock. - Innovative techniques address current treatment challenges and limitations effectively. - Ongoing clinical trials are yielding promising results, marking a significant advancement in septic shock management. #HealthcareInnovation #SepticShock #ClinicalTrials #Biotechnology #PatientCare #MedicalResearch #HealthTech https://lnkd.in/dUitYDHU

This Clinical Evidence Synopsis summarizes systematic reviews regarding pharmacologic interventions for proliferative vitreoretinopathy. https://ja.ma/4dVc5AE

𝗣𝗮𝘁𝗶𝗲𝗻𝘁 𝗖𝗵𝗿𝗼𝗻𝗼𝘁𝘆𝗽𝗲 𝗖𝗼𝘂𝗹𝗱 𝗜𝗺𝗽𝗮𝗰𝘁 𝗕𝗲𝘀𝘁 𝗧𝗶𝗺𝗲 𝘁𝗼 𝗧𝗮𝗸𝗲 𝗕𝗹𝗼𝗼𝗱 𝗣𝗿𝗲𝘀𝘀𝘂𝗿𝗲 𝗠𝗲𝗱𝗶𝗰𝗮𝘁𝗶𝗼𝗻 A new study showed that hypertention patients had a reduced risk of heartattack when taking their medicine aligned to their body clock. Chronotherapy matters to control blood pressure with antihypertension medication. This is a new finding of a study conducted by University’s School of Medicine of the University of Dundee, in collaboration with #HelmholtzMunich, and in partnership with an international team of researchers from Italy, UK and the USA - published in eClinicalMedicine. 👉 Learn more: https://lnkd.in/dsEx-FDH Kenneth Dyar Filippo Pigazzani #chronotherapy #hypertension #therapy #BodyClock #InnerClock #chronotype #heartattack #PersonalizedMedicine #circadianmedicine #SRBR2024 #cardiovasculardisease

Check out this review paper conducted by our SGH’s Prof Manju Chandran with the International Osteoporosis Foundation, exploring the impact of osteoporosis medications on fracture healing. This research provides insights that challenge previous assumptions and reaffirm the safety of continuing osteoporosis treatment post-fracture. Manju Chandran #SGH #MedicalResearch #Osteoporosis #FractureHealing #definingTomorrowsMedicine #DareToInnovate

Why some injured kidneys do not heal . Investigators have discovered why some injured kidneys heal while others develop scarring that can lead to kidney failure. Their findings could lead to the development of noninvasive tests to detect kidney scarring and, eventually, new therapies to reverse the condition. #ScienceDailynews #InnovativeResearch #NextGenScience #ExploringFrontiers

Journal Club Fridays SMART Trial (2018): Balanced Crystalloids vs. Saline in Critically Ill Adults - Conducted in five ICUs at an academic medical center - Included 15,802 patients - Intervention: Compared saline to balanced solutions like Lactated Ringers (LR) or Plasmalyte - Results: Patients receiving balanced crystalloids had a lower rate of a composite outcome, which included death from any cause, new renal replacement therapy, or persistent renal dysfunction, compared to those receiving saline. My Thoughts: The SMART trial, along with the SALT-ED study (2018), has largely resolved debates on the benefits of balanced crystalloids over normal saline. Lactated Ringer's (LR), with its more physiologic composition, is the preferred fluid for resuscitation, second only to blood. In this study, balanced crystalloids showed significant advantages for kidney function compared to saline. Saline’s acidotic effect makes it less ideal for resuscitating patients with severe traumatic or septic shock. The only exception where I prefer normal saline over LR is in patients with traumatic brain injury (TBI), due to its higher sodium content.

PLEASE lobby #biopharma, the Centers for Disease Control and Prevention The National Institutes of Health, World Health Organization, FDA, and others to fund #sepsis research and development. YES< it's complicated but so are patients with #cancer #neurodegeration #aging #covid19 #elderly #antimicrobialresistance #genomic #mutations and #infectiousdiseases. The trial below targets the sickest patients, with an average initial Sequential Organ Failure Assessment (SOFA) score of 11, indicating a greater than 90% mortality rate. This inclusivity is essential, but it also means at the low end of our inclusion criteria of SOFA score of 5 (about 50% mortality rate), clinicians may also be hesitant to enroll patients with a high risk of death on an experimental drug. Additionally, at the high end of our inclusion criteria of an initial SOFA score of 11 (greater than 90% mortality rate, families of patients with severe conditions often opt for palliative care rather than trial participation. #omics WHO facts: https://lnkd.in/gJdHUJDX Sepsis Alliance