Join me in celebrating 100 years of EEG, please reshare!
On July 6th, 1924 Hans Berger recorded the first EEG on a human, only published in 1929. This invention of the EEG has resulted in many clinical applications ranging from diagnosing epilepsy and sleep disorders to Brain Machine Interfaces (BMI/BCI), neurofeedback and EEG as the first clinically actionable biomarker in precision and stratified psychiatry.
What's your favorite application of EEG?
See the full series 'Pioneers of the EEG' here: https://lnkd.in/giNVN5q also in Spanish.
Hansberger was born in Noises in 1873 and dreaming of becoming an astronomer, he began his academic career as a mathematics student. After just one semester, he abandoned his study and enlisted for a year of service in the cavalry. One day something happened. His platoon was on a training exercise when burgers horse reared, causing him to fall right in the path of a horse drawn cannon. His life flashed before his eyes and he knew he would die in an instant, but the driver of the cannon stopped in time, and Burger could crawl out of its way unharmed. At that exact same moment, his sister, many kilometres away, felt he was in danger and she urged her father to send hands a telegram to ask if he was alright. Later, Hansberger said about the incident. It was a case of spontaneous telepathy in which, at a time of mortal danger and as I contemplated certain death, I transmitted my thoughts, while my sister, who was particularly close to me, acted as the receiver. The event aroused Burgers fascination with the brain, and when he resumed his studies at the university, he changed his subject to medicine with the goal of discovering the Physiology of psychic energy. He obtained his medical degree in 1897 and joined the staff of Otto Binswanger at the clinic in Jaina and he started to record from the cortical surfaces of dogs, becoming senior lecturer at the university in 1906 and physician in chief in 1912. During World War One, he served as an army psychiatrist on the Western Front. A year after the war, he succeeded Binswanger as Chair in psychiatry. He continued to record from the cortical surface, this time of humans. In 1924, while experimenting on his son Klaus and on others, he recorded the first human electroencephalogram, or EEG. But filled with doubt, he postponed publishing his observations for five years. When he published DAS Electroencephalogram in 1929, the discovery of the alpha EEG rhythm, also called the Berger rhythm, and the beta rhythm were described for the very first time. Unfortunately, his discovery was met with disbelief and disdain by the scientific establishment. Among other German psychiatrists, he was a bit of an oddball. It would take until 1937 before the importance of his research was recognised and his discovery of the Alpha rhythm was confirmed by Edgar Adrian and Brian Matthews. In 1938, he was 65 years old. The Nazis were bad. Any work on electroencephalography and Burger was made professor emeritus in psychology, which is a nice way of saying he was sidelined. Berger took his own life in 1941. His discovery of the EEG is his lasting legacy.
Neuroinflammation in Psychiatry 🚨 - CFS / ME / Long Covid / POTS ...
It's become more important than ever for psychiatrists to learn about neuroinflammation and understand its implications with the increase in presentations of Long Covid, CFS, POTS, etc.
Neuroinflammation is a key player behind the scenes in treatment resistance within psychiatry, entangling with mitochondrial functions, neurotransmitter systems, the immune-endocrine systems, the endothelium and more...
In this short snippet from our 10-hour accredited course, I touch on the ME/ CFS and Long Covid Overlap.
So please Grab a cup of☕️, and let's go back in time. (15 min video - time limit)
"In history, a great volume is unrolled for our instruction, drawing the materials of future wisdom from the past errors and infirmities of mankind". (Burke)
So, In this video, I take you back to 2020, then a decade ago to 2013, and then from there, you will go back to 1975.
From there, you will come to the present and realise why the overlaps between CFS / ME and Long Covid are unsurprising.
Research is split between Dysautonomia, MCA, EDS, #CFS, and #LongCovid when, really, the multiple specialities should be coming together!
Patient consent was obtained for images (some modified)—big thanks to Prof Graham Hughes.
Our 10-hour accredited course journeys into CFS, Long COVID, Fibromyalgia, MCA (Mast Cell Activation Syndrome), EDS (Ehlers-Danlos Syndromes), and POTS equips clinicians with a comprehensive guide to navigate these complex conditions.
We link pharmacological (and non-pharmacological) treatments to underlying pathophysiologies, illustrated through case studies, enabling a more nuanced understanding and management of these conditions.
You can learn lots more (10 hrs) in the Neuropsychiatry of #CFS / LC and #Fibromyalgia course. (Academy membership) 👉https://lnkd.in/gTY-iVn3
Individual purchase 👉https://lnkd.in/gEKicSRu#CFS#ME#longcovid#POTS
Some excellent Tuesday reading here on #neuroplasticity as the emerging framework for depression biology.
As the psychiatry field rapidly evolves, it can be challenging to overcome old perceptions among the general public and clinicians. This is particularly true for depression therapies, where terms like 'chemical imbalance' are still widely used.
Here, Page et al. highlight how "the serotonin deficit hypothesis of major depressive disorder (MDD) has continued to persist despite insufficient supporting evidence"
Page also emphasizes communicating how "effective treatments for MDD enhance neuroplasticity mechanisms to restore synaptic, network, and behavioral function to facilitate cognitive and emotional processing"
Gate Neuro is committed to advancing next-generation treatments for depression, and other CNS diseases, that target core neuroplasticity biology for better patient outcomes
#neuroplasticity#synapticplasticity#drugdevelopment#biotech
An analysis of 15,000 de-identified Tempus nP PGx patient records, recently published in Molecular Psychiatry, revealed that 65% of patients had CYP2D6 and CYP2C19 phenotypes actionable for medication prescribing. More than half of the top 25 most frequently prescribed medications in psychiatry are metabolized by CYP2D6 and CYP2C19, emphasizing the importance of these findings. Access the full manuscript here: https://tempus.co/3VMYjZW
𝗔𝗿𝘁𝗶𝗰𝗹𝗲 𝗧𝗶𝗽💡AI breakthrough: faster match between patient and antidepressant
A new AI-driven method developed by Dutch researchers can now predict whether the antidepressant sertraline has an effect using brain scans and questionnaires. The technique has already made correct predictions in two-thirds of cases. This could shorten the treatment time to assess a drug’s effectiveness from months to just one week.
Scientists from Amsterdam UMC and Radboudumc have developed a predictive model that can predict the effectiveness of sertraline by analyzing brain scans and questionnaires. The study, published in the American Journal of Psychiatry, highlights the role of brain perfusion as an indicator and has the potential to improve treatment protocols for depression dramatically.
Read the full article here👇
https://lnkd.in/eqT2_mHw#artificialintelligence#antidepressant
One size does not fit all.
Glad to have co-authored this invited article with Stögmann Elisabeth for Jatros Neurology and Psychiatry. We provide a short update on sex differences in #Alzheimer and why they are going to be relevant in clinical practice and trials.
We argue that, as new drugs are appearing for the treatment of Alzheimer, we will need a personalized approach to select patients who are more likely to respond (with low side effects) and adjust regimens. Biological sex will be one of the variables to consider; one-size-fits-all will not work, in my opinion.
Link in comments (article in German).
#gendermedicine#precisionmedicine#sexdifferences
Congratulations to Elsevier Senior Acquisitions Editor Joslyn Chaiprasert-Paguio and book editors JOÃO LUCIANO DE QUEVEDO (McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth Houston), André R. Brunoni (USP - Universidade de São Paulo), and Clement Hamani (Sunnybrook Research Institute) for the publication of "Interventional Psychiatry: Road to Novel Therapeutics". Authored by leading experts and internationally contributed, this comprehensive guide explores the full spectrum of specialized interventions, from established methods like electroconvulsive therapy (ECT) to cutting-edge approaches such as ketamine infusion therapy and psychedelic therapies.
Here's what makes this book a must-read:
🔍 Seamlessly blends established and emerging methodologies, offering a fresh perspective on psychiatric intervention.
🔍 Dives deep into the mechanisms behind interventions, providing invaluable insights into their efficacy.
🔍 With clear indications, contraindications, and techniques, this resource is designed to be practical and accessible.
🔍 For those looking to specialize, the book outlines guidelines for fostering fellowships in Interventional Psychiatry, shaping the future of the field.
Perfect for Psychiatrists, Psychologists, Neurologists, and Neurosurgeons—whether in academic or private practice settings.
#InterventionalPsychiatry#MentalHealth#Innovation#PsychiatricTreatment
My latest with Helen Lavretsky in Translational Psychiatry! Randomized, controlled trial to assess the efficacy of Kundalini yoga training (KY) compared to memory enhancement training (MET) on mood and cognitive functioning in a group of older women with cerebrovascular risk factors and subjective cognitive decline (NCT03503669). At 24-weeks follow-up, KY yielded a significant, large effect size improvement in subjective cognitive impairment measures compared to MET. On a transcriptional level, at 12- and 24-week follow-up, KY uniquely altered aging-associated signatures, including interferon gamma and other psycho-neuro-immune pathways. Levels of chemokine eotaxin-1, an aging marker, increased over time in MET but not KY participants.
https://lnkd.in/gH5H4w-i
NCCPA-certified PA, Stephen McCarthy PA has an MS in Physician Assistant Studies, a BS Medical Studies from DeSales Univ with 8yrs inpatient/outpatient psychiatry, addiction med, weight management & hormone therapies.
I am excited to share this new study from Translational Psychiatry that shows the potential of a novel brain stimulation technique called Stanford Accelerated Intelligent Neuromodulation Therapy (SAINT) in reducing suicidal ideation in patients with major depressive disorder (MDD). This is a groundbreaking discovery that could pave the way for more effective and rapid interventions for patients with MDD who are at high risk of suicide. I encourage you to read the full article here and learn more about this innovative and promising therapy.
New research from King's College London reveals a significant association between reduced grey matter in the brain and Early Onset Psychosis (EOP), with the largest-ever brain imaging study in EOP showing decreased grey matter across nearly all brain regions. The study involved 482 individuals with EOP compared to 469 healthy controls from international sites, providing unprecedented detail about the illness. Researchers hope the detailed brain mapping will aid future diagnosis and treatment tracking for EOP, which manifests before age 18 and presents challenges in understanding due to limited research.
#BrainResearch#PsychiatryInsights#EarlyOnsetPsychosis
Retired professor york university
3moGood to see you remembered your history 👏🤭