RIBOPRO’s Post

- Overview - Specifications - Shipping, Reconstitution & Storage - General View of Documents - Declaration - Quick Inquiry Overview General Description mRNA Cap 2'-O-Methyltransferase, utilizing S-adenosylmethionine (SAM)

- Overview - Specifications - Shipping, Reconstitution & Storage - General View of Documents - Declaration - Quick Inquiry Overview General Description mRNA Cap 2'-O-Methyltransferase, utilizing S-adenosylmethionine (SAM)

Along with enzymatic engineering of T7RNAP (https://lnkd.in/eJvwz5Yr), optimization of transcription reactions is another way to decrease dsRNA impurities during IVT #mRNA, #mRNAvaccines

Initially developed to encapsulate mRNA for vaccines, our Impingement Jets Mixing (IJM) technology is now leading the way in creating bioavailable, tolerable, and efficacious mRNA therapies. 🧬💊   Key Features: High Encapsulation Efficiency: Achieve optimal mRNA encapsulation with precision and reliability. Homogenous Particle Size Distribution: Ensure uniformity for consistent and effective therapy delivery. Customizable Mixing Conditions: Tailor the encapsulation process for unique mRNA strands to maximize efficacy.   Pre-clinical R&D is crucial for discovering the ideal conditions for API encapsulation, allowing you to test and perfect your formulation on a smaller, cost-effective scale before scaling up. This approach not only reduces costs but also accelerates time-to-market, making your therapies available sooner. 💡   The IJM NanoScaler is designed specifically for this purpose—to optimize and streamline the path from development to production. 🔬 #thinklnp #thinkknauer #lnp #mrna

🔔Discover the Hidden World of Drug Reactions! 🔔 - Most adverse drug reactions are predictable (Type A), but unpredictable (Type B) reactions pose unique challenges. - Mast cells are involved in pseudoallergies which differ from common allergies. - Different drugs can trigger pseudoallergies through various mechanisms without prior sensitization. Ever wondered about the complexities of drug reactions at injection sites and how to assess them to de-risk your drug candidates? 🔍 Explore how non-IgE-mediated reactions can directly stimulate mast cells, leading to the release of mediators and the clinical symptoms we often mistake for common allergies. Don't miss out on understanding how these reactions can affect the safety and efficacy of injectable therapeutics. 👉🏻https://bit.ly/4bBin6T #DrugDevelopment #DrugSafety #Pharmacology #Pseudoallergy #Biotech #Genoskin #InjectionSafety #MastCells #Immunotoxicity

Detecting double-stranded RNA (dsRNA) is crucial in ensuring the purity of mRNA products. Discover how BA Sciences' innovative Dot Blot technique to detect impurities like dsRNA during mRNA manufacturing, enhancing quality control and regulatory compliance Read the whitepaper at https://hubs.ly/Q02TPdhx0 – #USPharma24 #GenerisPMOS #mRNAmanufacturing #mRNA #dsRNAdetection #mRNApurity #qualityassurance

New mMESSAGE mMACHINE T7 mRNA Kit with CleanCap Reagent AG with industry-leading mRNA yield per reaction is featured in this Application Note focusing on the impact of mRNA modification and purity on effective expression and reduction of in vivo toxicity.

Have you heard about the higher activity of the new RNA capping enzyme from New England Biolabs and the improved approach for LC-MS mRNA cap analysis? https://lnkd.in/eppPzaBw 💡 Learn about Faustovirus Capping Enzyme (FCE) advantages over Vaccinia Capping Enzyme (VCE) for mRNA manufacturing, and how RNase 4 simplifies mRNA cap LC-MS analysis design in the latest NEB blog post.

New mMESSAGE mMACHINE T7 mRNA Kit with CleanCap Reagent AG with industry-leading mRNA yield per reaction is featured in this Application Note focusing on the impact of mRNA modification and purity on effective expression and reduction of in vivo toxicity.

NEW EGFP IVT mRNA Aggregation by Size Exclusion Chromatography Using a Biozen™ dSEC-7 Column https://lnkd.in/gkgsHCPi