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Do people treated with GLP-1s lose more muscle than those who lose weight through other means? Ro’s advisor, David Allison, and Ro’ers, Raoul Manalac and Lauren Broffman, PhD, took a close look at what the evidence had to say. In short, here’s what they found: ➡️ There’s a lack of evidence that GLP-1s lead to disproportionate muscle mass loss; ➡️ There is evidence that suggests GLP-1s may lead to improved body composition, as the loss of fat mass is often 2-3x greater than loss of fat free mass; ➡️ One study reported that GLP-1s significantly improved physical function compared to placebo. Learn more in their article, and stayed tuned for future deep dives on this topic: https://lnkd.in/eFCMBimw

Normative vs Excess Muscle Loss and Strength with GLP-1 Medications vs Other Weight Loss Methods

Normative vs Excess Muscle Loss and Strength with GLP-1 Medications vs Other Weight Loss Methods

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Tzvi Doron, DO

Healthtech Exec Committed to Patient-First Innovation | Ro Employee #3 | Startup Leader | Strategic Advisor | Builder of High-Performing Teams

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Pemvidutide, like tirzepatide, seems to cause less lean mass loss than semaglutide. However, most longevity research shows that muscle function is more important than muscle mass. IOW muscle strength is more important than muscle mass. Previous research on weight loss (mostly diet-induced) has shown decreases in muscle mass with preserved muscle strength. The thinking is that intramuscular fat interferes with muscle function so that weight-loss induced muscle loss may come with *improved* muscle function. What we need is studies that compare muscle strength before and after drug-induced weight loss. An even better study would be to have another study arm with resistance training.

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