RockStep Solutions’ Post

Our mission is to improve the human relevance of biomedical research and develop alternative methods to animal testing. Three-dimensional bioprinting is used to generate organ models that are then used for various biomedical research applications. In addition to animal welfare, an advantage of this approach is that human cells are used, and the humanized models may have greater relevance to human disease than animal models. Our focus is on models for the lung and the liver. We use the bioprinted organ models to carry out infection studies. Furthermore, we develop cancer models. A particular strength of bioprinting is the opportunity to includes a vascular system to the organ model, which allows perfusion of the models.

We’re pleased to present the results of a head-to-head animal study between OV329 and vigabatrin (VGB), the only FDA-approved GABA-aminotransferase (GABA-AT) inhibitor. Today’s findings suggest a compelling and potentially differentiated profile for OV329. The findings presented at the Epilepsy Pipeline Conference, showed that OV329 cleared and remained undetectable in the retinas, eyes, and brains of mice, suggesting a lack of accumulation. In contrast, this study shows, as has been seen in previous studies, VGB accumulates in these tissues. Full results from the head-to-head animal study will be presented at the 2024 American Epilepsy Society conference in December. Read the press release here: https://lnkd.in/eeaygviR

What opportunities do emerging technologies offer animal health? Advanced technologies such as artificial intelligence and stem cell therapy provide more efficient tools to predict, prevent, diagnose and treat animal illness. Discover more in our infographic ⬇️

Dystonia and Paroxysmal Dyskinesias: Under-Recognized Movement Disorders in Domestic Animals? A Comparison with Human Dystonia/Paroxysmal Dyskinesia Involuntary hyperkinetic movement disorders that share common clinical features with different types of dystonia and paroxysmal dyskinesias in humans are described in dogs, horses, and cattle. While genetic analyses have shown that the currently recognized movement disabilities termed as CMD in cattle do not seem to represent dystonia, it has yet to be clarified if hyperkinetic movements in dogs and horses are dystonic in nature. As neurophysiological examinations in patients with dystonia show specific EMG patterns, this may help to clarify diagnosis. Since muscle cocontractions of antagonistic muscles and phasic tremulous and/or non-tremulous muscle activity represent the hallmarks of dystonia, these would help to distinguish between possible diagnoses in affected animals. Although attempts at treatment with GABAmimetic drugs like benzodiazepines in dogs may be effective in some cases, the outcomes are inconsistent. Except for disorders with clearly defined genetic causes, the origin and the mechanisms underlying of the described movement disorders in domestic animals remain mostly unknown. Therefore, further postmortem studies and genetic analysis to determine the underlying pathophysiology and genetics of these conditions are required.

For anyone in the preclinical Imaging space!

Answer: using discoveries about animal health and disease to improve human medicine. Some animals are uniquely suited to helping Colorado State University researchers develop new medicines and therapies that could benefit both animals and humans: 🐕 = key research areas: cancer, trauma, epilepsy, cognitive dysfunction, osteoarthritis 🐎 = key research areas: sports medicine, orthopedics, metabolic disease, eye (ocular) cancer 🐈 = key research areas: inflammatory bowel disease, intestinal lymphoma, infectious disease, type 2 diabetes, chronic renal failure 🦇 = key research area: infectious disease 🐑 = key research area: musculoskeletal system From Dean VandeWoude, College of Veterinary Medicine and Biomedical Sciences: "Veterinarians receive a broad education about the biology and diseases of not just one animal, but many of the four-legged variety and can’t help but naturally apply those principles to our own diagnoses, and those of our family and friends." Learn more about how CSU is championing translational research to improve the health of animals and humans: https://lnkd.in/e2-GFNkh

At CER Groupe, we're committed to continuing to advance research while prioritizing animal welfare. The recent inclusion of animal welfare in the Belgian constitution aligns with our dedication to ethical practices in scientific research. We've equipped our facility with a state-of-the-art stereotaxic frame for rodents to test the efficacy of new treatments for brain tumors, which affect both adults and children. Each year, tumors are diagnosed in children under 15, with one-quarter being brain tumors. Stereotaxy allows us to precisely target specific brain regions, minimizing side effects and reducing the number of animals required for preclinical studies. This technique not only controls pain more effectively but also promotes the 3Rs (Replacement, Reduction, and Refinement) in research. We recently welcomed Roane Lee from @RWD to demonstrate develop the stereotaxy technique, enhancing our capabilities and ensuring precision in our research. Our studies are conducted under the expertise of Aurélie Henry, who has extensive experience through her PhD and post-doctoral work in this field. hashtag #CERGroupe #Neuroscience #AnimalWelfare #3Rs #BrainTumorResearch #Innovation #Stereotaxy #LifeSciences #Oncology

March is Endometriosis Awareness Month. In this article, we discuss why animal-based research on endometriosis has thus far failed to elucidate the causes of the disease or facilitate a cure, and highlight how research on endometriosis can succeed without the use of animals. #EndometriosisAwarenessMonth #endometriosis #NonAnimalMethods #NAMs #AnimalFreeResarch https://lnkd.in/esb9F6B2

🚨 Last call to register for our October 2nd webinar at 1:00 PM EST on "Advances in Neurological Disease Animal Models" with Dr. Dong Han! Don’t miss your chance to learn about cutting-edge neurological research and animal modeling techniques. 🔗 Register now: https://lnkd.in/ewcwEskM #NeurologicalResearch #BiocytogenWebinar #AnimalModels

A new mechanism for shaping animal tissues