Pan-cancer analysis of post-translational modifications An analytical resource of posttranslational modifications (PTMs) from over 1,000 patients across 11 cancer types reveals pan-cancer changes involved in hallmark cancer processes and reveals potential new therapeutic avenues. The authors found 33 pan-cancer multi-omic signatures and PTM dysregulation is associated with distinct DNA damage repair mechanisms. They also found that changes in acetylation of metabolic proteins correlate with tumor immune state and phosphorylation of Thr/Ser kinases is affected by proximal acetylation. #sciencenewshighlights #ScienceMission https://lnkd.in/g9A95Qdh
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