Sakshi Mural’s Post

Our director, Dr. Robert Green MD, MPH, a Harvard geneticist, spoke to Bloomberg in this article about the promises and challenges of using DNA tests to improve health. “If you combine genetic risk with targeted care and surveillance for those individuals at higher genetic risk, I believe that you can change outcomes,” Green emphasized. Just as it was impossible, decades ago, to predict what we might learn from decoding the genome, we can’t yet be sure what else we might find as we continue to untangle its myriad connections. Will DNA tests like 23andMe actually help people live longer and healthier lives? Read here to know: https://lnkd.in/gzz-WGmN #Genomes2People #Research #HealthResearch #TranslationalResearch #Science #ScientificResearch #TranslationalScience #Genetics #DNA #Genes #PreventiveGenetics #GeneticResearch #Genome #Genomes #Genomics #PreventiveGenomics #TranslationalGenomics #GeneticTesting #GeneticCounseling #GeneticConditions #GeneticDisorders #RareDisease #GeneticCounselors #Geneticists #MedicalGeneticists #Screening #Sequencing #NewbornSequencing #DNASequencing #DNATesting #WholeGenomeSequencing #Health #PrecisionHealth #PublicHealth #PopulationHealth #NewbornHealth #ChildrenHealth #PreventiveHealth #PreventativeHealth #PersonalizedHealth #HealthForAll #HealthEquity #HealthData #HealthNews #EvidenceBasedMedicine #HealthOutcomes #Healthcare #PreventiveHealthcare #PersonalizedHealthcare #HealthcareInnovation #Technology #MedTech #Engineering #FutureOfHealthcare #Medicine #EquitableMedicine #PrecisionMedicine #PreventiveMedicine #PreventativeMedicine #PersonalizedMedicine #GenomicMedicine #BioMedicine #Biology #Biotechnology #Biomedical #HealthSciences #HealthCommunication #ScienceCommunication #SciComm #Philanthropy #GoodCause

TL;DR Diverse genomes are better than a monolithic population set for understanding genetic causes of disease Great paper from the Million Veterans project authored by a team including Anurag Verma, Ph.D. and Katherine Liao. They used a diverse set of 600,000 genomes to conduct widespread GWAS. Compared to the UK Biobank, this set used a much more diverse population and had great results. Suma ( Sumitra) Muralidhar, PhD - coauthor and Million Veteran Program Director "The findings from this study, one of the largest and most diverse of its kind, will allow researchers to uncover critical insights that will drive better health outcomes for veterans from all backgrounds, helps pave the way for advances in how we deliver the personalized healthcare our diverse Veteran population deserves." Euan Ashley: “This work sets a new bar for multi-ancestry genomic analysis and represents a major step forward towards diverse representation in the genomics literature,”

As someone with a pathogenic missense variant, I know first hand how important it is to better understand them. Each of us typically carry more than 9,000 missense variants - alternations in genetic code. Most of them are benign and have little to no effect, but others are pathogenic and can severely disrupt protein function and cause diseases. Understanding which genetic variants are likely to be pathogenic can help improve diagnosis and treatment, especially for rare diseases. Google DeepMind developed AlphaMissense, an AI model which categorizes missense variants as either "likely pathogenic" or "likely benign." Now I'm proud to announce that we've partnered with European Bioinformatics Institute | EMBL-EBI to integrate AlphaMissense scores into a suite of their open access tools - AFDB, Ensembl, ProtVar and Uniprot -to help thousands of researchers use AlphaMissense scores. Overlaying AlphaMissense scores onto AlphaFold structures provides researchers with additional insights into protein function, such as potential binding interfaces, to further their research. I look forward to seeing how scientists use these insights to accelerate their work and our collective knowledge - and how that may ultimately enable those of us with pathogenic missense variants to have more opportunities to manage our health. Learn more in the link below. https://lnkd.in/efW5A6JM

𝐁𝐫𝐞𝐚𝐤𝐢𝐧𝐠: 𝐂𝐥𝐢𝐜𝐤 𝐄𝐝𝐢𝐭𝐢𝐧𝐠 𝐓𝐚𝐤𝐞𝐬 𝐨𝐧 𝐏𝐫𝐢𝐦𝐞 𝐄𝐝𝐢𝐭𝐢𝐧𝐠 𝐟𝐨𝐫 𝐏𝐫𝐞𝐜𝐢𝐬𝐞𝐥𝐲 𝐖𝐫𝐢𝐭𝐢𝐧𝐠 𝐆𝐞𝐧𝐨𝐦𝐞𝐬 Click editing leverages the unique properties of DNA-dependent polymerases and RNA-programmable nickases and avoids the risks associated with double-strand breaks. “We sought to develop a genome editing approach that enables the facile and precise installation of nearly any genetic change into a chromosome while also overcoming challenges of other technologies” - Ben Kleinstiver, Massachusetts General Hospital and Harvard Medical School. https://lnkd.in/dJs2K54S #crisprmedicinenews #crisprmedicine #geneediting #crispr #clickediting

Our upcoming webinar on Feb. 28 will explore the importance of secure research environments for genomic data analysis at scale. Learn how existing research environments tackle these challenges and highlight how data can be extracted in a secure and scalable manner for publication and dissemination within the scientific research community. https://bit.ly/3HzJemE #genomics #dataanalysis #IQVIA

Cracking the Genetic Code ! Dive in and join us in this live webinar on genomics workflows happening on 24th May 2024 at 10am . Explore the latest advancements and the keys for a success genomic research result . Register by scanning the QRcode below and reserve your seats now .

Unraveling the blueprint of health is a journey of discovery. At Mosaic Biodata, we delve deep into the intricate world of genetics to decode how our genes influence athletic ability. Through cutting-edge science and personalized insights, we empower individuals to understand their genetic predispositions and optimize their performance. Genetics isn't just about inherited traits; it's about unlocking potential. Our team at Mosaic Biodata is dedicated to providing clarity and actionable information based on your unique genetic makeup. Whether you're an athlete striving for peak performance or someone curious about their health, our genetic testing services offer valuable insights into predispositions related to endurance, strength, injury risks, and more. Join us in exploring the intersection of genetics and athleticism. Discover how understanding your genetic blueprint can guide your training, recovery, and overall health journey. At Mosaic Biodata, we're committed to advancing personalized medicine through rigorous scientific research and practical applications that benefit individuals and healthcare providers alike. #Genetics #HealthScience #AthleticPerformance #PersonalizedMedicine #GeneticTesting #MosaicBiodata #PrecisionMedicine #GeneticInsights

The future of medicine lies in its ability to serve everyone, regardless of their genetic background. Unfortunately, much of the current genomic research is centered around populations of European ancestry, leaving significant gaps in our understanding of how treatments affect people from diverse backgrounds. In this fascinating article by Genetic Engineering & Biotechnology News, I emphasized the critical role of genomic diversity in making medicine more equitable. We discuss the pressing need to expand genomic research beyond populations of European ancestry. Doing so will not only advance healthcare for underrepresented communities but also unlock the full potential of precision medicine for everyone. As someone deeply involved in genomic diversity research, I believe that including African and other underrepresented genomes is vital for shaping the future of medicine. 🌱🌍 The article sheds light on the strides we're making and the challenges we still need to overcome to ensure genomic equity. Read the full article here and join the conversation on how we can create a healthier future for all. #Genomics #GenomicDiversity #PrecisionMedicine #EquityInHealth #DiverseGenomes #GlobalHealth #RepresentationMatters https://lnkd.in/eqE3dAd3

Excited to dive deeper into the world of genetic engineering! 🧬 I recently had the opportunity to attend “CRISPR Chronicles: Rewriting Genetic Diversity In Disease”, hosted by SciBug and presented by the inspiring Prerna Mehta, Ambassador of the Microbiologists Society. This webinar was a mind-expanding journey into how CRISPR is pushing the boundaries of science, enabling us to rewrite the genetic blueprint of diseases. The potential for revolutionizing medicine through this technology is incredible, and I can’t wait to see where it takes us next! 🚀 Always eager to keep learning and exploring new innovations in biotech! #CRISPR #GeneticInnovation #FutureOfScience #BiotechRevolution #LifelongLearner #SciBug #BreakthroughsInBiology

🎙️ Exciting News! 🎙️ 🔬 Dive into the world of gene sequencing and rare diseases on the latest Podcast Cruzamento episode with Tiago R Magalhaes. Discover how gene sequencing is transforming healthcare and learn about the Emirati Genome Program's groundbreaking work. 🧬 Tiago explains the importance of gene sequencing in improving patient care and discusses the high prevalence of rare diseases in the UAE. Explore the unique approach of the EGP and its impact on global healthcare. 💡 Whether you're a healthcare professional or simply curious about the future of medicine, this episode is a must-listen! Tune in now and join the conversation shaping the future of healthcare. 📢 Don't forget to leave us a five-star rating on your favorite podcast app and connect with Tiago Magalhães on LinkedIn for more insights. Let's continue spreading knowledge and making a difference in healthcare together! #CruzamentoPodcast #GeneSequencing #RareDiseases #EmiratiGenomeProgram #HealthcareInnovation https://lnkd.in/dASy_jyx (CC: Daniel Guedelha, Andre Correia, Beatriz Isabel Cruzeiro) #cruzamentopodcast #digital #digitaltransformation #saude #portugal #estrategia #criatividade #liderança #inovacao #investimento #science #technology #ciencia #tecnologia #sustentabilidade #saúdedamulher #saúdeinclusiva #EngenhariaBiomédica #FuturoSustentável #InovaçãoTecnológica