San Diego Biotechnology Network’s Post

📊 Secondary analysis of the PRE18FFIR study showed individual coronary atherosclerotic plaque activity is associated with subsequent myocardial infarction in the same coronary artery territory, which cascades into patient-level risk 🫀 The research underscores the importance of monitoring biological plaque activity to predict better and manage heart attack risks. 📚 Read more about these findings in the Journal of the American College of Cardiology: https://bit.ly/45fT9Jf + editorial https://lnkd.in/gR3uHRsV +podcast by Prof. Fuster. 📚 Original paper JAMA Cardiology https://lnkd.in/gDBia5td #Cardiology #HeartHealth ❤️ #JACC #AHA

Dr. Emmanuel Ekanem, a cardiac electrophysiologist with Winchester Cardiology and Vascular Medicine | Valley Health, was the lead investigator in groundbreaking clinical research surrounding the study of pulsed field ablation in patients with atrial fibrillation (AFib). He is the lead author of a new paper, published today in the prestigious journal Nature Medicine, entitled 'Safety of pulsed field ablation in more than 17,000 patients with atrial fibrillation in the MANIFEST-17K study.' This study has significant implications for the newly FDA approved nonthermal ablation technology, which utilizes ultrarapid electrical pulses with preferentiality for myocardial tissue to treat AFib. This innovative new technology reduces the risk of injury to surrounding cardiac tissue and procedure times. Dr. Ekanem and global colleagues across Europe played an important part in establishing the safety profile for this new technology. Congratulations to Dr. Ekanem on this important publication! Read the full study here: https://lnkd.in/emkMnpH6 #Pulsedfieldablation #Atrialfibrillation #Naturemedicine

A research study co-authored by Suneet Mittal, MD, FACC, FHRS, Chair of the Cardiovascular Service Line for Valley Health System, was recently published in the Journal of Cardiovascular Electrophysiology. The authors of the study presented results of the FROZEN AF trial, unveiling a novel 28mm cryoballoon system for treating paroxysmal atrial fibrillation (PAF). Conducted across 10 countries, this study demonstrates impressive results with 95.7% complete pulmonary vein isolation achievement and 79.9% freedom from documented atrial arrhythmia recurrence at the 12-month mark. This research underscores the safety and efficacy of this innovative cryoballoon, offering promising avenues for patients with drug-refractory or drug-intolerant PAF. To read the full study, please visit https://lnkd.in/eBMyVGr7. #CardiacResearch #CardiacPublication #Electrophysiology #MedicalResearch

Cardiovascular, Neurovascular & Stroke (CVNS) Journal is an open-access, multidisciplinary, peer-reviewed medical journal for cardiovascular, neurovascular, as well as stroke medicine. CVNS accepts and publishes articles that revolves around these specialties including the new trends in image-guided therapy (IGT). Submission Details: We welcome manuscripts that meet the general criteria of significance and scientific works in the mentioned subject areas. There is no article processing charges (APC) imposed on submissions. Manuscripts can be submitted at: https://lnkd.in/g2zmGZtz #callforpapers #callforsubmissions #cvns #stroke #cardiovascular #neurovascular #medicine

With 450+ citations, this landmark paper shaped angiogenesis research. 🩸 This seminal review from Harvard Medical School, written by Dr. Patricia D'Amore and Dr. Robert W. Thompson, reveals the complex mechanisms of angiogenesis. Key factors influencing endothelial cell (EC) growth and angiogenesis: - Mechanical forces - Cell-cell interactions - Extracellular matrix - Growth factors, esp. heparin-binding growth factors (HBGFs) The authors highlight the potential of HBGFs as novel therapies for conditions involving abnormal blood vessel growth, such as ischemic heart disease. This groundbreaking paper has shaped the field of angiogenesis research and continues to inform our understanding of cardiovascular physiology and disease. Read the full paper via the link in our comments section. #angiogenesis #medicine #research #science #medical

Join us on July 23, 2024, at 10:00 am EST for an insightful webinar with Bronwyn Berkeley, a final-year PhD student at The Queen’s Medical Research Institute at The University of Edinburgh in the Mairi Brittan Group. Bronwyn will dive into her research on cardiac lymphangiogenesis and neovascularisation after myocardial infarction, focusing on: Visualizing cardiac vasculature by immunostaining using the Compresstome vibratome. The role of lymphatic and blood vascular responses to myocardial infarction. How modulation of these responses can improve patient outcomes post-ischemic injury. Register for free: https://lnkd.in/eKkSzPrP #CardiacResearch #MyocardialInfarction #PrecisionaryInstruments #compresstome #microtomes #vibratingmicrotomes #vibratomes #tissuesectioning #precisioncuttissuesslices #tissueslicing #laboratoryequipment #labsolutions

In this video, Quentin R. Youmans, MD, MSc, reflects on his medical education at Northwestern University Feinberg School of Medicine. He discusses his clinical focus of heart failure and heart transplantation, and his passion for improving health equity and increasing diversity in medicine. https://lnkd.in/gnvYSHG3

LHI Lecture May 15, noon: “Human Cardiac Metabolism” Zoltan P. Arany, M.D., Ph.D. Director, Translational Research, Division of Cardiovascular Medicine Cardiovascular Institute Presidential Associate Professor Perelman School of Medicine University of Pennsylvania More about Dr. Arany from the UPA website: https://buff.ly/3UkgMw6 Location: 1-101 Microbiology Research Facility (MRF) 689 23rd Ave SE, Minneapolis, MN Map: https://buff.ly/3VJm19Z Webcast @ buff.ly/4cIssQI Learning Objectives: 1. Appreciate evidence that human heart failure may have metabolic component 2. Understand the use of different fuels by the hear in health and heart failure 3. Appreciate molecular mechanisms that lead to alterations in fuel use in heart failure 4. Recognize results of efforts to date and ongoing efforts to modulate cardiac metabolism in human heart failure

The two papers, "Heat shock protects cardiac cells from doxorubicin-induced toxicity by activating p38 MAPK and phosphorylation of small heat shock protein 27", and "HSP27 regulates p53 transcriptional activity in doxorubicin-treated fibroblasts and cardiac H9c2 cells: p21 upregulation and G2/M phase cell cycle arrest", first appeared nearly 20 years ago. A physiology journal has retracted these papers after an institutional investigation found a heart researcher falsified data and figures in the articles. A committee at the Ohio State University found Govindasamy Ilangovan, an associate professor of cardiovascular medicine at the school, falsified figures and reused data, according to the retraction notices published in Heart and Circulatory Physiology, a journal of the American Physiological Society. One of the papers received a corrigendum in 2021 over a figure "published incorrectly" in the original paper. The investigation found that Ilangovan falsified the updated figure in the corrigendum, and the original "was inaccurate because of the reuse and relabeling" of a Western blot. The retraction notices detail how Ilangovan repurposed and relabelled Western blots from both published and unpublished works. #article, #journal, #publication, #author, #image, #retract, #retractionwatch https://lnkd.in/dzTvrpqe

#RCM Sharing a new Review "Left Atrial Hemodynamics and Clinical Utility in Heart Failure" by Dr. Chun-Yen Chen et al. #leftatrium #heartfailure #LAP #Hemodynamics Full Text: https://lnkd.in/db8BCdki Reviews in Cardiovascular Medicine