Santhera Pharmaceuticals’ Post

Do you know lablife.video? Even if you aren’t in biotech, cell biology 🧫 or similar fields, they have the videos for you to understand the work in cell labs! 🥼 #startup #entrepreneurship #femaleentrepreneurs

GIQuant is deployed in #IBD clinics, research and #ClinicalTrials. Meet #Motilent 's leadership and science teams at #ECCO24 #Stockholm to learn more about quantitative measurement of GI motility in #crohns and #uc Email our conference coordination team at: info@motilent.io to book a slot. What is #GIQuant? #GIQuant generates a bowel wall motility heat map and score from very short, easy to capture, non-invasive, cine #MRI - the higher the GIQuant score the more motile the bowel wall in the selected area. Below left are coronal cine MRI of the same patient at 2 timepoints: baseline, top ; and follow-up, bottom . We see a suspiciously immotile bowel segment in the baseline image (lower right quadrant abdomen) which is selected as an ROI for observation pre and post treatment, in this case for Crohn's. The dysfunctional segment is also visible in the zoomed coronal and transverse MRI images. To the right are colored GIQuant motility heat maps for each time point - read these as same-plane overlays to the MRI - on these you can see the selected ROI. Subjectively, in the heat map images, we can clearly see more coloring across the bowel at follow-up compared to baseline, equating to higher motility at follow-up. This is visible at the ROI too. Quantitatively, the GIQuant score rises in the selected ROI from 83.4 at baseline to 308.1 at follow-up, indicating a substantially more motile bowel wall at follow up. Motilent - Changing the way we see the gut www.motilent.io #ECCO2024 #crohnsdisease #drugdevelopment #inflammatoryboweldisease

🎉 This year, we're celebrating the 150th anniversary of the birth of Nikolai Korotkov, a visionary whose invention has significantly advanced the field of medicine. 🏥 🔍 The blood pressure measurement method developed by this Russian surgeon represents a milestone in medical history. Known as Korotkov Sounds, these are produced during blood pressure measurement using a cuff and stethoscope, allowing doctors to monitor patients' blood pressure more accurately. This technique involves listening for specific sounds in the arteries as the cuff pressure is gradually released. These sounds, referred to as Korotkov phases, form the basis for an accurate reading of systolic and diastolic pressure. 💡 This innovative method revolutionized cardiac diagnostics, enabling early detection and treatment of numerous cardiovascular diseases. It's fascinating to note that modern technologies, such as digital blood pressure monitors, still rely on the principles discovered by Korotkov. 🌐 As we honor Korotkov's 150th birth anniversary, let's reflect on how this breakthrough has transformed healthcare, continuing to benefit millions globally. 🌟 #NikolaiKorotkov #MedicalHistory #HealthcareInnovation

Excited to share that I recently attended the CTR (Centre for Trophoblast Research) Annual Meeting at Churchill College in Cambridge. The discussions were incredibly insightful, focusing on the emerging models of human and non-human primate placental development. Many questions I had were answered during the talks, and the inspiring panel discussions helped me better understand the challenges we face when applying trophoblast models in the future. There are two key takeaways I'd like to share: 1. There were comments on placenta-on-chip models, highlighting interest in how these in vitro models can address questions regarding various cell types communication in placenta and placenta- maternal/fetal organs communication. 2. There was a strong call for standardized protocols and datasets, which are crucial for developing reliable models and fostering a better research community. It's inspiring to see the advancements in this critical area of research and to connect with experts who are driving innovation in understanding placental biology. #Research #PlacentalDevelopment #TrophoblastResearch

As my mentor Heinz Redl always cited Claude Bernard: "Art is I, Science is WE" (not under-appreciating arts, personally I love to write poems (in case you are interested, please contact me personally): #extracellularvesicles meet #tissueengieering and #regeneration. What a perfect connection between our societey (Austrian Society for Extracellular Vesicles - ASEV), at the international congress of the Tissue Engineering and Regenerative Medicine International Society, Inc. (TERMIS) #TERMIS2024. Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA 😎

Increase the productivity of your scientific work using TauSTED Xtend! 📹 Cytoskeleton dynamics in live cells with TauSTED Xtend 589. Mouse neuroblastoma cells with LifeAct-mNeonGreen showing actin filament dynamics. Cell line courtesy: Prof. Olivier Perutz, Max Heydasch. University of Bern, Switzerland. Make the most of your "window of opportunity" during experiments by seeing what happens as it happens. With TauSTED Xtend, you no longer need to wait for completion before seeing results and making adjustments, helping you to work more efficiently. By taking advantage of the on-the-fly monitoring of results, you’ll be more confident that you are observing the right processes. ✅ Directly monitor fast processes with nanoscale resolution ✅ Get instant feedback for more efficient adjustments. Read the application note for more information: https://lnkd.in/eag7-f3v #CellularResearch #InnovativeScience #FLIM #Confocal #Microscopy #Research #LifeScience

The journey leading to the publication of the multicenter randomized clinical trial #ARGO in the prestigious journal *Ophthalmology* is the result of twenty years of R&D activity. This journey has been accompanied by a prolific production of studies and scientific articles, culminating in this crucial step. It is also the outcome of the tireless commitment of the co-founders of Regensight and the dedication of every person who has been going to contribute with seriousness, competence, and mindful conviction. The most remarkable aspect is the driving force behind this all: to provide a tangible (or rather, visible!) result in the treatment of #keratoconus through theranostics, an actual #paradigm #shift. This has been pursued relentlessly to give the only necessary guarantee to ophthalmologists and patients: #scientific and #clinical #evidence available to everyone! And today, we at Regensight have achieved it. #ophthalmology #eyecare #cxl #precisionmedicine #predictivemedicine #personalizedmedicine #theranostics #theracxl

I am really looking forward to attending and giving a talk on merging MSI images with mIF, H&E and other modalities. Hopefully I can see some of you there. #phenoplex #spatialbiology #multiplexpathology

We are not slowing down‼ We have a second great news, Ebi Maleki from JCEThas also received funding for a PRELUDIUM project funded by the NCN Narodowe Centrum Nauki entitled "Heart Failure-Induced Alterations in Platelet Phenotype: Impact on Lung Microvascular Endothelial Barrier Integrity". This research aims to investigate how heart failure (HF) induces changes in platelet phenotype and the resulting effects on the integrity of the lung microvascular endothelial barrier. By understanding the mechanisms by which HF-altered platelets affect endothelial function, the project seeks to identify regulatory factors that could modulate the biological function of platelet-derived TGFβ1. Huge congratulations‼🥳🥂🎊

Helium (He) is typically used as a coolant for the superconducting magnets in MRI machines because of its extremely low boiling point (around -269°C or -452.2°F). However, it is a non-renewable resource, and its scarcity leads to increased costs and supply chain vulnerabilities. Additionally, #helium management in #mri machines involves complex infrastructure and maintenance. Philips BlueSeal magnet is industry-leading solution to Helium-Free MRI Technology and represents a significant advancement in medical imaging. It eliminates the dependence on helium, reducing operational costs and the need for frequent refills of liquid helium. This solution has a notable impact on Environmental, Social, and Governance (ESG) criteria, particularly in the environmental domain. It offers a more sustainable and cost-effective alternative to traditional systems, decreases carbon footprint in usage and associated logistical transportation. The alleviated dependency on helium and reduced cost make MRI more accessible worldwide, which can enhance safety and diagnostic capabilities in underserved regions, contributing to better health outcomes and equity. Moreover, helium-free systems help healthcare facilities comply with stringent environmental regulations, align with corporate sustainability goals and reporting requirements, demonstrating commitment to sustainable practices and building stakeholder trust. With BlueSeal becoming more prevalent, we are shifting to a helium-free MRI world, and creating significant positive impact in the society and in the future. Find more on Philips #BlueSeal -> https://lnkd.in/exVVthsd Atul Gupta, MD https://lnkd.in/etqduuv5 #Philips #innovation #ESG