Sapient’s Post

Discover protein degradation fundamentals in this guide, including the ubiquitin-proteasome system (UPS) and the autophagy-lysosomal system (ALS), backed by illustrations, pathways, and therapeutic strategies. http://ms.spr.ly/6049iL0Gx #drugdiscovery

Introducing Huma NephroMatrix Coat, kidney ECM derived from nutrient-rich human kidney tissue maintaining native matrix proteins and growth factors providing a highly relevant environment for advanced cell culture applications. Huma NephroMatrix is ideal for in-vitro kidney models, renal disease studies, and #tissueengineering. It enables accurate disease modeling and aids in therapeutic development. Be a part of the future in kidney research and #regenerativemedicine with clinically relevant, affordable, and supply stable #biomaterials. Learn more about Huma NephroMatrix Coat here: https://lnkd.in/gjV7xkyE #cellculture #biomedical #drugdiscovery #cancerresearch

Last chance to register for our free lipidomics webinar with Pfizer expert Natalie Daurio. Explore the latest advancements in technology for lipidomics research and get practical guidance into investigating metabolic diseases. Sign up here: https://lnkd.in/eeNq7CMj #webinar #lipidomics #metabolomics

Dive into the World of Lipidomics with Our Latest Video! Ever wondered how lipids shape biological processes and impact disease research? Our video breaks down lipidomics, exploring advanced techniques like GC-MS and LC-MS, and their vital role in uncovering new biomarkers, driving drug development, and more. Whether you're in academia or industry, gain valuable insights into how precise lipid profiling can advance your research. Watch the video now and explore how Creative Proteomics' services can elevate your work in lipidomics. Watch now: https://lnkd.in/g8AVni8n #Lipidomics #MassSpectrometry

💡 Focus on... Season 1 Episode 2 This week, florence fauvelle, a research scientist from the team, shows us how "NMR-based metabolomics is becoming a tool for routine clinical diagnostic". This is related to her work in the lab in collaboration with Sabrina Boulet and David Mallet ! Follow our page to stay tuned with the next episodes of "Focus on..." ✔️ #NMR #Metabolomics #Parkinson

Understanding genetic influences on drug metabolism, such as CYP2C9 polymorphisms, is crucial in tailoring effective treatment plans for Alzheimer’s patients. Personalized dosing strategies, based on genetic profiling, can enhance the safety and efficacy of therapies like THC in managing Alzheimer’s symptoms. Embracing personalized medicine approaches, informed by genetic research, can pave the way for better outcomes and improved quality of life for individuals battling Alzheimer’s. #PersonalizedMedicine #GeneticInfluences #AlzheimersCare #DrugMetabolism #HealthResearch BioMedHack.com is your leading source for the latest news, breakthroughs, and insights in medicine, biohacking, and alternative medicine. Our mission is to help you live healthier and longer by bringing you cutting-edge information and expert advice. Follow us on Facebook, Instagram, and X. Read more about this post here: https://lnkd.in/ezU8iPQu

Check out a new trio of interesting articles on medical science and technology. First up concerns MIT researchers that have identified more than 300 liver genes that follow a circadian clock, including genes involved in drug metabolism, and other functions. This may help develop better dosing schedules for existing drugs. https://lnkd.in/eqYMprXT Next, there is a machine learning model designed to predict inpatient hypoglycemic events using only capillary blood glucose (CBG) that has shown excellent performance. https://lnkd.in/gpb5mZY9 Thirdly, is a publication about a woman who became the second person ever to receive a genetically modified pig kidney and the first person to receive a heart pump and a transplanted organ together. https://lnkd.in/gFyCTX_t #manhattanlife #medicalscience #medicaltechnology #healthcarefindings

Background α-Synuclein (αS) aggregation is the main neurological hallmark of a group of neurodegenerative disorders, collectively referred to as synucleinopathies, of which Parkinson's disease (PD) is the most prevalent. αS oligomers are elevated in the cerebrospinal fluid (CSF) of PD patients, standing as a biomarker for disease diagnosis. However, methods for early PD detection are still lacking. We have recently identified the amphipathic 22-residue peptide PSMα3 as a high-affinity binder of αS toxic oligomers. PSMα3 displayed excellent selectivity and reproducibility, binding to αS toxic oligomers with affinities in the low nanomolar range and without detectable cross-reactivity with functional monomeric αS. Results In this work, we leveraged these PSMα3 unique properties to design a plasmonic-based biosensor for the direct detection of toxic oligomers under label-free conditions. Significance and novelty We describe the integration of the peptide in a lab-on-a-chip plasmonic platform suitable for point-of-care measurements of αS toxic oligomers in CSF samples in real-time and at an affordable cost, providing an innovative biosensor for PD early diagnosis in the clinic.

Biomarkers and treatment options, just what we like to read about. Check out this new article in #JIMDReports Clinical, biochemical and molecular characterization of a new case with FDX2-related mitochondrial disorder: Potential biomarkers and treatment options Parith Wongkittichote, Cassandra Pantano, Miao He, Xinying Hong, Matt Demczko https://lnkd.in/eBa9NtrH

Can the dead help the living? It appears so! By using postmortem liver tissue, we were able to establish a substantial cohort for examining CYP genotype and hepatic protein correlations. This type of data is rare, as obtaining liver tissue from living individuals is challenging due to limited availability. So, how can data from those who have passed benefit the living? This information is crucial for informing precision dosing and creating realistic virtual populations for pharmacokinetic simulations! https://lnkd.in/d3fsg8ir