Sarah Cannon Cancer Network’s Post

Research from the UK using genetic therapy and mice studies has uncovered a potential treatment to reverse a rare skin disease. Congenital melanocytic naevus syndrome (CMN) is a rare skin condition that creates giant moles which can lead to skin cancer (melanoma). The study, at The Francis Crick Institute, London, developed a genetic therapy that can counteract the effect of an inherited mutated gene (named NRAS) which is directly responsible for this skin condition. Veronica Kinsler, lead researcher, said, "These results are very exciting, as not only does the genetic therapy trigger self-destruction of the mole cells in the lab, but we have managed to deliver it into the skin in mice." Ada, a 3-year-old girl with 70% of her body covered in CMN, contributed skin cells for the research. Her parents said: "Knowing there has been a huge step forward in CMN research and there could be a chance of Ada’s CMN being reversed and possibly reducing Ada’s risk of developing melanoma, has blown our expectations out of the water." Read more: https://lnkd.in/ejzXSZfb #AnimalResearch #SkinDisease #SkinCancer #Melanoma #CancerResearch #Mice

A case was reported with 2 green signals on chromosome 21 and 2 red signals on chromosome 12 . Green and Red signals of the normal chromosomes 12 & 21 with yellow & white signals here revealing tel gene on chromosome 12 and AML1 gene on chromosome 21 are fused. #rare #case #cancer #treatment #leukemia #molecular #cytogenetics

Exciting news in the world of medical research! 🔬 Genetic variants increasing breast cancer risk have been identified in African ancestry females, leading to improved risk prediction and targeted therapies. Uncover the findings here: https://ow.ly/Jwiy50Shq2A #research #oncology #breastcancer #genetics #immunotherapy

My fifth scientific publication as a principal author and my third with the distinguished French researcher, Professor Salima HACEIN-BEY-ABINA, an international pioneer in gene therapy who achieved the first therapeutic success with this approach. In this study, published in Frontiers in Immunology, we established a thorough comparison between two types of genetically modified immune cells, CAR-T and CAR-NK cells, in the treatment of hematological cancers. My thanks go to all the team: Salima HACEIN-BEY-ABINA, Andrada Chiron, Stéphanie Bessoles, and Guillaume Sarrabayrouse. 🔗 Link to the article: https://lnkd.in/gG_mQEWc #CancerResearch #Cancer #GeneTherapy

We are proud to continue our collaboration with Rznomics Inc. who recently received both Orphan Drug and Fast Track designations from the FDA for RZ-001, underscoring the potential clinical impact of this pioneering RNA-based gene therapy on both liver and brain cancers. "This signifies an important milestone in developing a safe and effective treatment for patients with GBM who require new therapeutic options." Dr. Seong-wook Lee (CEO) Glioblastoma multiforme (GBM), the most common malignant brain and central nervous system (CNS) tumors, accounts for around half of all cases, while hepatocellular carcinoma (HCC), the most prevalent type of primary liver cancer, accounts for 80% of cases globally. Read the story in full: https://okt.to/T3l0Dq #genetherapy #RNAtherapy #anticancer #orphandrug #livercancer #HCC #braincancer #GBM James Cody

Attending the American College of Medical Genetics and Genomics Annual Clinical Genetics Meeting? Don't miss our exhibit theater presentation covering the significance of screening, risk assessment and diagnosis, and also uncover the latest in diagnostic genomic testing in oncology. #WomensHealth #Oncology #Genetics #ACMG24

Attending the American College of Medical Genetics and Genomics Annual Clinical Genetics Meeting? Don't miss our exhibit theater presentation covering the significance of screening, risk assessment and diagnosis, and also uncover the latest in diagnostic genomic testing in oncology. #WomensHealth #Oncology #Genetics #ACMG24

Attending the American College of Medical Genetics and Genomics Annual Clinical Genetics Meeting? Don't miss our exhibit theater presentation covering the significance of screening, risk assessment and diagnosis, and also uncover the latest in diagnostic genomic testing in oncology. #WomensHealth #Oncology #Genetics #ACMG24

Attending the American College of Medical Genetics and Genomics Annual Clinical Genetics Meeting? Don't miss our exhibit theater presentation covering the significance of screening, risk assessment and diagnosis, and also uncover the latest in diagnostic genomic testing in oncology. #WomensHealth #Oncology #Genetics #ACMG24