Sarah Kittel-Schneider’s Post

Next lecture on Philosophy & Psychiatry Seminar (Institut društvenih nauka - Institute of Social Sciences): “The Drug Worked for Me” … But Did It? Jacob Stegenga (with Hamed Tabatabaei Ghomi) In his presentation, Dr Jacob Stegenga will question whether inferences from patients' first-person experiences about the effectiveness of their prescribed psychiatric drugs are reliable. Join us on April 18, 11.00 CET! 🙂 https://lnkd.in/dXymfvE5

New TMS research: Effects of TMS on Anhedonia and Suicidal Ideation in TRD: Outcomes from the University of Minnesota Interventional Psychiatry Program Article states, "A developing literature suggests that transcranial magnetic stimulation (TMS) can target anhedonia and suicidal ideation (SI), core symptoms of treatment-resistant depression (TRD). This present naturalistic study extends the existing literature by investigating the connection between changes in anhedonia and suicidal ideation (SI) related to transcranial magnetic stimulation (TMS), independent of any overall changes in depression." #TMS #depression https://lnkd.in/g9cmMkvq

Very intriguing article discussing the effects of TMS on anhedonia and suicidal ideation (SI) in Treatment-Resistant Depression (TRD)! Interesting Discussion Points to Consider: 1. TMS showed efficacy for ameliorating anhedonia and SI, core TRD symptoms that respond poorly to first-line depression treatments. 2. TMS related reductions in anhedonia and SI were similar in magnitude (d=1.03 and d=0.88 respectively) to reductions in other depression symptoms (Cohen’s d=0.97), replicating previous work demonstrating the capacity of TMS to effectively target these difficult to treat symptoms. 3. TMS associated changes in anhedonia and SI are linked independently of changes in other depression symptoms. Summary: 1. The study's findings indicate that broad dlPFC targeting, whether with the Figure-8 or H1-coil, is sufficient to achieve substantial reductions in anhedonia and SI. 2. The findings suggest that TMS-induced changes in anhedonia and SI may be linked, supporting the idea that they may potentially share a common neural substrate. Great work by the Minnesota Interventional Psychiatry Program! Looking forward to hearing more! #neuroscience #depression #neuromodulation #TMS

Some excellent Tuesday reading here on #neuroplasticity as the emerging framework for depression biology. As the psychiatry field rapidly evolves, it can be challenging to overcome old perceptions among the general public and clinicians. This is particularly true for depression therapies, where terms like 'chemical imbalance' are still widely used. Here, Page et al. highlight how "the serotonin deficit hypothesis of major depressive disorder (MDD) has continued to persist despite insufficient supporting evidence" Page also emphasizes communicating how "effective treatments for MDD enhance neuroplasticity mechanisms to restore synaptic, network, and behavioral function to facilitate cognitive and emotional processing" Gate Neuro is committed to advancing next-generation treatments for depression, and other CNS diseases, that target core neuroplasticity biology for better patient outcomes #neuroplasticity #synapticplasticity #drugdevelopment #biotech

OUT TODAY in Frontiers in Psychiatry! Research Topic: Neuropsychiatric disorders in the veterans volume II: emerging evidence of precision medicine and complementary and integrative health (CIH) approaches Accounting for the mental health of our servicemen and servicewomen is a critical area of concern that must not be underestimated. The unique experiences of military personnel, whether in combat or training, may make them more vulnerable to psychological distresses that are not necessarily common among civilian life. Veterans make significant contributions to their countries, and along with their duties to serve, comes a cost related to psychological and mental health burdens that must be acknowledged and managed. The features in this Research Topic illuminate several neuropsychiatric disorders and propose novel therapeutic CIH interventions that can be applied to support and advance our treatments of neuropsychiatric health in veterans. Learn More in Frontiers in Psychiatry | Frontiers Editorial 👉 https://lnkd.in/ecAZ69a6 Editorial: Neuropsychiatric disorders in the veterans volume II: emerging evidence of precision medicine and complementary and integrative health (CIH) approaches - Giulio Maria Pasinetti, Wes Ashford, Andrea Durham, Divyash Shah, Dr. Vrinda Saxena and Josh Palmieri, LMSW View all six articles:  👉 https://lnkd.in/ei7yiU5C Icahn School of Medicine at Mount Sinai The Mount Sinai Hospital Graduate School of Biomedical Sciences at the Icahn School of Medicine James J. Peters Veterans Affairs Medical Center War Related Illness and Injury Study Center, U.S. Department of Veterans Affairs Palo Alto VA Hospital Stanford University

My latest with Helen Lavretsky in Translational Psychiatry! Randomized, controlled trial to assess the efficacy of Kundalini yoga training (KY) compared to memory enhancement training (MET) on mood and cognitive functioning in a group of older women with cerebrovascular risk factors and subjective cognitive decline (NCT03503669). At 24-weeks follow-up, KY yielded a significant, large effect size improvement in subjective cognitive impairment measures compared to MET. On a transcriptional level, at 12- and 24-week follow-up, KY uniquely altered aging-associated signatures, including interferon gamma and other psycho-neuro-immune pathways. Levels of chemokine eotaxin-1, an aging marker, increased over time in MET but not KY participants. https://lnkd.in/gH5H4w-i

🧠 Beyond One-Size-Fits-All: Precision Psychiatry Is Here The field of psychiatry is experiencing a transformative shift toward precision medicine, a paradigm that tailors treatment to the unique characteristics of individual patients. This approach echoes advances in fields like oncology and cardiology, where precision tools have already revolutionized patient care. "Neuroimaging techniques, particularly fMRI, have revolutionized our ability to map and quantify circuit abnormalities. Neural circuit measurements potentially offer the most direct window into the neural bases of psychiatric symptoms and, crucially, their modulation by treatment" → To learn more about precision psychiatry, read the latest Medscape article: https://lnkd.in/gGRp2Drs Laura M. Hack Leanne Williams Stanford University Stanford University School of Medicine #research #neuroscience #psychiatry #mentalhealth

An analysis of 15,000 de-identified Tempus nP PGx patient records, recently published in Molecular Psychiatry, revealed that 65% of patients had CYP2D6 and CYP2C19 phenotypes actionable for medication prescribing. More than half of the top 25 most frequently prescribed medications in psychiatry are metabolized by CYP2D6 and CYP2C19, emphasizing the importance of these findings. Access the full manuscript here: https://tempus.co/3VMYjZW

Psychotic disorders as a framework for precision psychiatry (2023) by Fiona Coutts, Nikolaos Koutsouleris and philip mcguire. Paywall access: https://lnkd.in/dy5TBuKk Further resources: 1) New and emerging approaches to treat psychiatric activity https://lnkd.in/dFpBjC4r 2) The foundation and architecture of precision medicine in neurology and psychiatry (2023) https://lnkd.in/gmCgj-K6 3) Drug targeting in psychiatric disorders — how to overcome the loss in translation? (2023) https://lnkd.in/dHGGUGYR 4) Magic shotguns versus magic bullets for mood disorders https://lnkd.in/dA8z_anz 5) Next generation treatments for mental health disorders https://lnkd.in/dQe6yXXy 6) Depression therapeutics https://lnkd.in/dT4NV9gC 7) Personalized antidepressant medicine https://lnkd.in/drjJnmXb 8) Opportunities and challenges in psychiatry drug discovery and development https://lnkd.in/dsMzxHvM 9) The druggable schizophrenia genome: from repurposing opportunities to unexplored drug targets https://lnkd.in/gaGwWqDM