Saroj Nishad’s Post

We at akp Communications are proud to present a new article by our client BENEO in the spring issue of Pharmaceutical Manufacturing and Packing Sourcer Samedan Ltd. 🚀 Focusing on the challenges of the pharmaceutical industry, BENEO has addressed the issue of formulating liquid plant extracts into solid oral dosage forms. Incorporating plant extracts into e.g. compressed tablets can be challenging both from a technical and sensory perspective: Plant extracts can be oily and sticky, sensitive to moisture, present storage and stability concerns, or have an unpleasant aftertaste and/or mouthfeel. 🌿 Dr. Maj-Britt Cepok at BENEO shares insights on how agglomerated Isomalt can help pharmaceutical manufacturers to overcome such hurdles. Discover how to leverage this water-soluble excipient for simple and effective formulations. Read the full article for expert perspectives and real-world examples. https://lnkd.in/eMCCruum #Pharma #Innovation #BENEO #galenIQ721 #featuredbyakpCommunications

Why do many active pharmaceutical ingredients like metformin, vancomycin, propranolol, and tamsulosin are made as HCI (Hydrochloride) salt? Many pharmaceutical drugs are manufactured as hydrochloride (HCl) salts for several reasons: 1. Solubility: HCl salts often have improved solubility in water, making them easier to formulate into liquid dosage forms or dissolve in the body. 2. Stability: HCl salts can provide greater stability to the drug molecule, reducing degradation or oxidation reactions. 3. Bioavailability: The HCl salt form can enhance the bioavailability of the drug, allowing it to be more easily absorbed into the bloodstream. 4. Crystallinity: HCl salts can form crystals with a consistent structure, making them easier to filter, dry, and compress into tablets. 5. Regulatory: Many regulatory agencies, such as the FDA, have established guidelines and monographs for HCl salt forms, making it easier to develop and approve these formulations. 6. Manufacturing: HCl salts are often simpler and less expensive to manufacture than other salt forms, as HCl is a common and inexpensive reagent. Some examples of pharmaceutical drugs manufactured as HCl salts include: -Tamsulosin HCl -Propranolol HCl -Metformin HCl -Ciprofloxacin HCl -Amitriptyline HCl These are just a few reasons why many pharmaceutical drugs are manufactured as HCl salts. The specific reasons may vary depending on the drug molecule and its properties... #PharmaceuticalSalts #HClSalts #PharmaManufacturing #DrugFormulation #PharmaceuticalChemistry #PharmaceuticalScience #MedicineDevelopment #PharmaceuticalIndustry #PharmaResearch #PharmaceuticalTechnology

𝗙𝗼𝗿𝗺𝘂𝗹𝗮𝘁𝗶𝗼𝗻 𝗙𝗿𝗼𝗻𝘁𝗶𝗲𝗿𝘀: 𝗜𝗻𝗻𝗼𝘃𝗮𝘁𝗶𝗼𝗻𝘀 𝗶𝗻 𝗣𝗵𝗮𝗿𝗺𝗮𝗰𝗲𝘂𝘁𝗶𝗰𝗮𝗹 𝗘𝘅𝗰𝗶𝗽𝗶𝗲𝗻𝘁𝘀 𝗚𝗲𝘁 𝗙𝗿𝗲𝗲 𝗦𝗮𝗺𝗽𝗹𝗲 𝗣𝗗𝗙 @ https://lnkd.in/dGMFzz-7 Generally, Pharmaceutical Excipients refer to substances other than active pharmaceutical ingredients (API) that have been precisely evaluated for safety, and are included intentionally for the purpose of drug delivery in a body. For example, Gelatin and Polyethylene Glycol is commonly used as excipient in the manufacturing of soft gel, hard capsules, ointments, solvents, and more. Likewise, sweetening agents are excipients that are commonly added to pharmaceutical dosage for the purpose of covering the bitter taste of the partially dissolved drug and for improving the palatability of the drug. There is no doubt that the COVID-19 lockdown has impacted the pharmaceutical excipients industry. Strict lockdowns all over the world interrupted the entire supply and trade of raw materials from manufacturing hubs like China, and India 𝗕𝘆 𝗧𝘆𝗽𝗲 𝗼𝗳 𝗙𝗼𝗿𝗺𝘂𝗹𝗮𝘁𝗶𝗼𝗻 ORAL FORMULATIONS TOPICAL FORMULATIONS PARENTERAL FORMULATIONS OTHER FORMULATIONS #pharmaceutical #pharma #pharmacy #pharmacist #medicine #pharmaceuticals #healthcare #pharmacology #medical #health #pharmacists #pharmacystudent #excipients #covid #pharmacytechnician #pharmacyschool #pharmd #research #pharmaceuticalindustry #science #doctor #pharmacymemes #biotech #pharmacylife #laboratory #drug #pharmacognosy #biotechnology #biology

Recent updates on nitrosamine impurities in pharmaceuticals point to a deeper understanding of their formation, not just during drug synthesis, but also through packaging materials, particularly during the heat-sealing of blister packs. According to findings by the EMA and FDA, excipients and packaging can also contribute to nitrosamine contamination. Manufacturers are now advised to consider adding antioxidants or adjusting the pH levels in their formulations to prevent nitrosamine formation during storage. Moreover, companies are expected to perform continuous risk assessments throughout the product's lifecycle, with regular testing under various manufacturing and storage conditions to maintain safety standards. #nitrosamines #pharmaceuticals #drugsafety #blisterpackaging #FDA #EMA #riskassessment #Packaging #excipients #qualitycontrol

Highly potent active ingredients (HPAPIs) require fill/finish systems that meet the highest requirements to protect both operators and the sterile product. To ensure the utmost quality and safety of injectable medicines, businesses may benefit from integrating an isolator into their line, notes OPTIMA packaging group's Lucas Meyer.  #pharmapackaging #pharmaceutical #pharmamanufacturing #sterilefillfinish #sterileinjectables https://lnkd.in/eP4CskH2

Nitrosamine Impurities: One group of substances known to be very carcinogenic are nitrosamines. They can develop in drug substances and drug products via a variety of processes, most frequently involving secondary amines and nitrites. Because of the possible health concerns associated with nitrosamine impurities, the pharmaceutical industry has paid close attention to them, and regulatory bodies have placed stringent restrictions on their use in medication products. How it formed : Numerous processes can lead to the formation of nitrosamines, especially when secondary or tertiary amines and nitrosating agents (such as nitrites) are involved. These are a few typical routes: 1) Reaction Between Nitrites and Amines 2) Degradation Pathways a) Chemical degradation b) Physical degradation 3) Contaminated Raw Materials a) Raw material used b) Control Cross-contamination So this will be the topic of our discussion from now on. please suggest , if you required to add anything specific in this series. Pic Courtesy : https://lnkd.in/eHKbETrY

Nitrosamine Update: Limiting Nitrosamine Formation. Researchers have developed an ultrasensitive method for quantifying nitrite in process water, revealing low risk for nitrosamine formation. Testing various water samples, they achieved an impressive LOQ of 0.1 ppb for purified water and WFI. Their findings suggest minimal nitrite presence in purified water, even under conditions favorable for nitrosamine formation. This method is pivotal for understanding and mitigating potential risks in drug manufacturing. Stay informed on these critical advancements in ensuring pharmaceutical safety. Read article here: https://okt.to/f7PKZY #Pharma #Nitrosamines #DrugSafety #AnalyticalChemistry #IndustryUpdate

#instantinternational SODIUM NITRATE #SodiumNitrate #ChemicalApplications #Fertilizers #IndustrialChemicals #NitrateCompounds #NitrogenFertilizers #Explosives #OxidizingAgents #ChemicalReactions #AgricultureChemicals #WaterTreatment #Chemicalindustry #NitrateSalts #SodiumNitrateUses #FoodPreservatives #pharmaceuticals #glassandpotteryenamels #metaltreatment #textileindustry #pyrotechnics #propellant #thermalrecovery

As the top brand in Chinese pharmaceutical packaging industry, WQS products research and development group tried their best for new products. We witness the efficiency of the new machine which can satisfy all the clients' Prefilled Syringes requirements. Strict operational norms and highest criterions are used in our factory workshops to ensure the quality of every Prefilled Syringes with different parameters . The scope of our WQS Prefilled Syringes Applications : √ Vaccine √ Heparin sodium √ Hyaluronic acids √ Interferon √ Infertility √ Protein polypeptides √ Monoclonal antibody √ Anesthetic √ MRI contrast agent #PharmaceuticalIndustry #glass #tube #vial #injection #Packaging #tablet #packaging #pharmaceutical #pharma #sustainability #nutraceutical #chemical #food #cosmetic #farmaceutica #chimica #cosmetica #alimentare #confezionamento #cartoni #manufacturing #vaccine #heparinsodium #hyaluronic #interferon #proteinpolypeptides #polypeptides #monoclonalantibody #anesthetic #MRIcontrastagent

💊 Ever Wonder What Makes a Drug "Highly Potent"? HPAPI (Highly Potent Active Pharmaceutical Ingredients) - the term that keeps pharmaceutical professionals on high alert! What Makes a Drug Highly Potent? 🔬 Key Parameters: • Therapeutic dose < 10mg per day • OEL (Occupational Exposure Limit) < 10µg/m³ • Active at nanogram levels • Biological activity at low concentrations Examples You Might Know: • Cancer medications • Hormonal drugs • Advanced antibiotics • Specialized pain medications Safety Measures Required: • Dedicated manufacturing facilities • Advanced containment systems • Specialized PPE protocols • Continuous air monitoring • Rigorous employee training Mind-Blowing Fact: Just 1 gram of a highly potent drug can be equivalent to 1000 doses of a regular medicine! The Real Challenge: Manufacturing these drugs is like handling dynamite - one small error can have massive consequences. #Pharmaceuticals #DrugSafety #PharmaManufacturing #HPAPI #Innovation #Healthcare