Heart failure affects an estimated 40 to 60 million individuals globally. Find out how Sartorius and the biotech company Repairon are #InThisTogether for a cure 🤝💛 Shortly after birth, our heart muscle cells lose their ability to divide. This means that damage such as a heart attack leads to an irreversible loss of these cells. As a result, the heart's ability to pump effectively decreases, which can lead to heart failure. For over two decades, the team at Repairon has been researching to develop the so-called heart patch. This new heart tissue is artificially grown from stem cells in the lab and then sewn onto special membranes compatible with the human body. ❤️🩹 ➡️ Discover how Sartorius supports Repairon in the production of stem cells for heart patches on the Sartorius Blog: https://ow.ly/gPXZ50Svinq #SimplifyingProgress #PartOfTheSolution #HeartFailure #HeartPatch #Production
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Today's effort at patient education: "Are Stem Cells Illegal?" MSK and Spine autologous cellular therapy injections (like #BMAC and #mFAT) may be considered "exempt" from FDA regulation --- when performed under the proper circumstances, and when specific criteria are met. On the other hand, there are currently ZERO (Zero.Point.Zero) FDA -approved "Stem Cells in a Vial" products for use in the treatment of MSK and Spinal Conditions in the USA. So if you got an invitation for the "Informational Seminar on Stem Cells" at your local steakhouse in the mail, and you show up and they start talking about Exosomes, Wharton's jelly, umbilical cord blood, and amniotic fluid, you might want to skip dessert and skeedaddle. I can't believe that these companies are still getting away with advertising, promoting, and distributing these products in 2024! Hopefully this video helps to clarify! https://lnkd.in/e4EBcuKV
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📚 Publication Alert: Nanovials used to optimize cell therapies! In a recent Nature Communications publication, researchers at UCLA used Nanovials to identify and isolate high EV secreting stem cells and used them as a therapeutic in mice, demonstrating improved tissue regeneration post-cardiac injury. Key Takeaways from the publication: 📌 EVs play an important role in cell-to-cell communication 💬, including tissue regeneration 📌 Traditional methods, which study EV-secreting cells in bulk, often mask this heterogeneity and typically destroy the cells, making it difficult to optimize EV therapeutics 📌 Nanovials were used to analyze and sort single cells based on EV secretion levels—cells are kept alive during this process 📌 Imaging cytometry 📸 using the Cytek Biosciences Amnis Imagestream helps distinguish different Nanovial populations 📌 Mice treated with high EV secreting populations isolated using Nanovials show increased tissue recovery after myocardial injury 🐭 🚀 Nanovials can facilitate the optimization of other EV therapies! Read the press release here: https://lnkd.in/gvf8U7ZW Read the publication here: https://lnkd.in/gGt2FTNP #CellTherapy #ExtracellularVesicles #Nanovials #Therapeutics
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Exciting research uncovers the therapeutic potential of extracellular vesicles (EVs) in regenerative cell therapies! #EVs #CellTherapy #ExtracellularVesicles #Flowcytometry #Cellsorting #Imagingflowcytometry #Imagestream Exeter Centre for Cytomics
📚 Publication Alert: Nanovials used to optimize cell therapies! In a recent Nature Communications publication, researchers at UCLA used Nanovials to identify and isolate high EV secreting stem cells and used them as a therapeutic in mice, demonstrating improved tissue regeneration post-cardiac injury. Key Takeaways from the publication: 📌 EVs play an important role in cell-to-cell communication 💬, including tissue regeneration 📌 Traditional methods, which study EV-secreting cells in bulk, often mask this heterogeneity and typically destroy the cells, making it difficult to optimize EV therapeutics 📌 Nanovials were used to analyze and sort single cells based on EV secretion levels—cells are kept alive during this process 📌 Imaging cytometry 📸 using the Cytek Biosciences Amnis Imagestream helps distinguish different Nanovial populations 📌 Mice treated with high EV secreting populations isolated using Nanovials show increased tissue recovery after myocardial injury 🐭 🚀 Nanovials can facilitate the optimization of other EV therapies! Read the press release here: https://lnkd.in/gvf8U7ZW Read the publication here: https://lnkd.in/gGt2FTNP #CellTherapy #ExtracellularVesicles #Nanovials #Therapeutics
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What are stem cells? Stem cells are particular types of cells that can develop into many different types of cells in the body. They have specialized functions such as self-renewal through cell division and differentiation into specific types of specialized cells, such as red blood cells, insulin-producing cells, neurons, or other blood cells. Did you know that GLUTATHIONE is needed to increase stem cell potency and differentiation?🙌❤️ GlutaMyst is a convenient, effective, efficient, delicious, and affordable INNOVATIVE DELIVERY TECHNOLOGY that gets 100% Pharmaceutical-Pure Medical-Grade Glutathione with a proprietary blend of 60 cellular nutrients into your body within 4 seconds and absorbs up to 99%.
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Stem cells: What are they and why are they important? Watch our video for an easy-to-understand breakdown! We created this video nearly 10 years ago and we are so excited about the progress made since then to advance this promising therapy. For example, clinical trials involving stem cells have skyrocketed from 1,190 (2010-2020) to 6,205 as of today. #StemCells #RegenerativeMedicine #MedicalResearch #ScienceEducation #BioTech #CellTherapy #HealthInnovation #FutureOfMedicine #StemCellResearch #MedicalBreakthroughs
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From drug discovery to organoid-based disease modeling, stem cells are increasingly being used in research as a vital tool for scientific investigation. Their specialized nature demands more intensive maintenance and culturing than most cell lines. Check out this Application Note from Sartorius that delves into novel solutions for iPSCs, ensuring consistency and high cell health. Check it out here! >>> https://bit.ly/3Sfobwe Learn more here: CellCelector - Single Cell, Colony or Organoid Selection and Retrieval
Application Note: Solutions for culturing, maintaining and characterizing iPSCs
biotechniques.com
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Disease modeling of human pathologies in vitro using human pluripotent stem cells (hPSCs) is increasing in the scientific community. Read about this novel method of hPSC clonal isolation to improve and upscale the generation of edited hPSCs required for downstream applications, including disease modeling and drug screening, and the role that CellCelector played. Read here: https://ow.ly/syME50Q1Xyy #stemcells #CRISPR #automation #cellcelector #lifescienceresearch
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Field Application Specialist @Sartorius || Ex-Dr Reddy's Laboratories LTD || Ex-Biocon Bristol Myers Squibb R&D Centre || Ex-CCMB || IIT Delhi || NIBM || Alumni of Sri Ramachandra University|| Alumni of Jain University
The Cellcelector platform plays a pivotal role in this endeavor by offering precise and efficient cell isolation capabilities. Researchers can use Cellcelector to selectively isolate specific cell populations derived from human pluripotent stem cells, allowing for the creation of complex in vitro disease models that closely mimic the cellular heterogeneity observed in human tissues. By enabling the isolation of disease-relevant cell types with high purity and viability, Cellcelector facilitates the development of more accurate and physiologically relevant disease models, ultimately advancing our ability to study disease mechanisms and identify novel therapeutic targets. Click on the link below to explore further on the technology. #cellcelector #automation #CRISPR #hPSCs
Disease modeling of human pathologies in vitro using human pluripotent stem cells (hPSCs) is increasing in the scientific community. Read about this novel method of hPSC clonal isolation to improve and upscale the generation of edited hPSCs required for downstream applications including disease modeling and drug screening and the role that CellCelector played: https://ow.ly/9zMo50QQPHm #stemcells #CRISPR #automation #cellcelector #lifescienceresearch
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MEMS removing the non-degradable proteins from the networks stops the cell degeneration in situ Between degeneration using chemicals and complicated regeneration, the ill patient cannot work. The transplantation is expensive and invasive, with the risk of infection, and social security is a problem in any country that cannot reimburse it. The company taking part in the studies has known from Axanton Technology GmbH for 10 years that removing the non-degradable proteins with Molecule Establishing Membranes Signaling (MEMS) regenerates the cells in situ and prevents cardiovascular pathology. MEMS is used sublingually at five micrograms per week to prevent cardiovascular pathologies in humans for 14 years. Where is the science and regulatory affairs policy to refuse all financial support since 2005 for MEMS and continue to tolerate the accumulation of the non-degradable proteins in the cell and the patients' degeneration? https://lnkd.in/eUSx5HyA
Latest Review on Human Pluripotent Stem Cell-Derived Cardiomyocytes published on #CellStemCell. Raniga and colleagues discussed the applications of hPSC-CMs in drug discovery and the path to clinical translation, highlighting several key challenges: 1. Raw Materials in Cardiac Differentiation Protocols The raw materials used in cardiac differentiation protocols are often of research grade and not optimized for clinical applications. Even when the focus is non-clinical research, it's important to consider the potential for future translational needs and adhere to relevant regulatory guidelines. I am looking at you, Matrigel. 👀🐭 2. Scaling Up the hPSCs Scaling up remains a significant hurdle in the realm of cell therapy. Traditional 2D differentiation processes fall short in scalability due to the inefficient surface area-to-volume ratio for cell growth. Bioreactor-based manufacturing has emerged as a solution, improving quality and overcoming many of these limitations. 📈 3. Gender-Balanced, Ethnically Diverse hPSC lines Let's address the elephant in the room - lack of diversity in clinical research. The current hPSC repositories in the US and Europe predominantly feature Caucasian lines, with an uneven distribution of male and female hPSC lines (who would have guessed, right?). While diverse donor cell lines are now available, they often come at a premium under custom services, making them an expensive option for researchers. 💸 Read the author's perspective in detail: https://lnkd.in/e3-kRPnK #ipsc #cardiomyocytes #celltherapy
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Senior Research Officer (Clinical Research Physician)/ Domain Expert in Digital Health/ Publisher / Medical Research Mentor
🧬 Revolutionizing Early Cancer Detection: MIT-Led Team Unveils Biomimetic Sensor Inspired by Cell Receptors 🦠📲 Imagine a world where you can detect cancer at its earliest stages with a simple at-home test, providing the opportunity for timely treatment. Thanks to a groundbreaking sensor developed by an MIT-led team, this vision is closer to reality. This sensor, inspired by the sensory systems in cells, mimics natural cell receptors to detect specific molecules. The prototype can identify immune molecules like CXCL12 at incredibly low concentrations, a crucial step towards enabling routine screens for elusive cancers and metastatic tumors. The innovative device draws inspiration from the membranes surrounding cells, housing thousands of receptor proteins that detect environmental molecules. The MIT team modified these proteins to withstand conditions outside the cell membrane, anchoring them in a layer of crystallized proteins on an array of graphene transistors. When the target molecule is detected, these transistors relay the information to a computer or smartphone. This biomimetic sensor can potentially analyze various bodily fluids, from blood to tears and saliva, simultaneously screening for different targets based on the type of receptor proteins used. The technology, named RESENSA (Receptor S-layer Electrical Nano Sensing Array), utilizes graphene transistors for their exceptional electrical properties and high sensitivity. With a density of 1 trillion receptors per square centimeter, the chip can reliably detect even rare molecules linked to early-stage tumors or diseases like Alzheimer's. This innovation not only brings us closer to early cancer detection but also opens doors to a wide range of healthcare applications. The dream of accessible, accurate at-home diagnostics is becoming a reality. 🌟💊🩺 #EarlyCancerDetection #BiomimeticSensor #HealthcareInnovation #MITResearch #GrapheneTechnology #MedicalBreakthrough #InnovationsInScience #CancerResearch #HealthTech #MedicalDevices https://lnkd.in/ggTNJTpz
Scalable biomimetic sensing system with membrane receptor dual-monolayer probe and graphene transistor arrays
science.org
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Senior Director, Business Development
1moThis is truly unique... almost like sci-fi, but real!