The School of Applied Functional Medicine’s Post

As a practitioner, you understand the detrimental impact of toxic overload on chronic disease progression. However, sustainable resolution can be elusive despite your best efforts, leading to frustration and suboptimal patient outcomes. Join us for our free, live online event on Thursday, May 23 at 7 pm ET. SAFM has assembled an esteemed panel, including Dr. Deanna Minich, Dr. Yael Joffe, Dr. Drew Kidder, and Tracy Harrison (SAFM Founder), to help you unlock the secrets of effective detoxification. Discover: - Unexpected genetic effects on detoxification and how to manage them - The role of mitochondria in resolving toxic overload - Powerful patient guidance missing from detoxification protocols. Don't miss this opportunity to gain valuable insights and transform your practice. Register for this important event. Link is in the comments! #PreventiveHealthcare #RootCauseResolution #RootCauseHealing #HealthcareTransformation #LifestyleMedicine #HolisticMedicine #HealthCoachTips #FunctionalMedicine #FunctionalMedicinePractitioner #SAFM #ClinicalToxicity #Detoxification

There is one therapy in late-phase development showing promise for cognitive impairment associated with #schizophrenia. Characterize the disease burden and unmet needs of patients with CIAS and more in this free #CME activity: https://bit.ly/4fgmCpF #MedEd #FOAMed

🌍 December 1-7 marks Crohn’s & Colitis Awareness Week—a time to talk about what often goes unsaid: living with inflammatory bowel disease (IBD) is about more than just physical symptoms. It’s about pain, fatigue, and invisible challenges like anxiety, depression, or the constant fear of social stigma. Over 10 million people worldwide face this every single day, often in silence. But the future doesn’t have to stay this way. Highly stable #VHH antibody therapies are paving the way for new possibilities: 🔹 Smarter, targeted treatments: Engineered to work precisely where they’re needed, minimizing side effects. 🔹 Oral options: Imagine a therapy that doesn’t rely on needles or frequent hospital visits—just a capsule that delivers effective, localized results. Less disruption. More quality of life. Because no one should face #IBD alone. We’re proud to join #CCAwarenessWeek led by the Crohn's & Colitis Foundation to raise awareness and support for the IBD community.

Patients with rare autoimmune diseases often suffer with “silent” symptoms that may not be properly diagnosed for years, with little hope for relief or remission. One of Pfizer’s scientists sat down with Jerry Williams – a person who has lived with a rare, debilitating autoimmune condition for 20 years – to discuss dermatomyositis, his diagnosis and health journey and their shared hope for the future of myositis treatment. Watch the latest episode of “Dear Scientist” to learn more. #PFEColleague https://bit.ly/4dDugtA

❗Coming soon❗ 🗓 Date: Wednesday, 27th November 2024 🕛 Time: 12pm – 1:30pm GMT (includes a 30-min live Q&A) 💻 Presenter: Antony Haynes BA (Hons) RNT mBANT 🎟 Cost: Complimentary Join expert Antony Haynes for a comprehensive look into the mechanisms driving #autoimmune diseases, including #coeliac disease, #psoriasis, and #multiplesclerosis. This session will examine the roles of oxidative #stress, heavy metal toxicity, #infections, and mycotoxins in autoimmune conditions. Webinar Goals: ✅ Understand key drivers behind autoimmune conditions ✅ Learn why autoimmune cases are rising ✅ Explore effective Functional Medicine approaches for better patient outcomes 👉 Reserve your spot: https://lnkd.in/eNfDqmbJ #AutoimmuneHealth #FunctionalMedicine #HealthcareTraining #AutoimmuneSupport #Webinar #NutriLink

For #psoriasis month read curated content from the Editor of JID Innovations including studies investigating the clinical manifestations of psoriasis, the pathogenesis of the disease as well as treatments. https://ow.ly/4SBX50T1cV3 #dermtwitter #medderm

Check out this short segment on NPR about the work we are doing to create customized #CRISPR therapies for #RareDisease patients. With insight from IGI's Fyodor Urnov and FDA CBER Director Peter Marks. Listen here: https://shorturl.at/nOG28 *Did you know zebras are a symbol for rare diseases? This comes from the expression, "When you hear footprints, think horses, not zebras." Rare disease patients are zebras.

Patients with rare autoimmune diseases often suffer with “silent” symptoms that may not be properly diagnosed for years, with little hope for relief or remission. One of Pfizer’s scientists sat down with Jerry Williams – a person who has lived with a rare, debilitating autoimmune condition for 20 years – to discuss dermatomyositis, his diagnosis and health journey and their shared hope for the future of myositis treatment. Watch the latest episode of “Dear Scientist” to learn more. #PFEColleague

Did you know a simple derivative of vitamin C is transforming the lives of children with congenital disorders of glycosylation? This breakthrough, led by Dr. Ethan Perlstein and the CDG Cure Collective is helping kids experience fewer seizures and improved symptoms—an incredible leap forward for CDG patients and their families. Seeing the before-and-after videos of children who have benefited from this treatment is nothing short of inspiring. These moments remind us why innovation and collaboration in rare disease research are so vital. #RareDisease #Innovation #PatientAdvocacy #DrugRepurposing

A drug repurposing approach worth analyzing. In PMM2-CDG, mutations in the PMM2 gene impair N-glycosylation by disrupting GDP-mannose production. This affects glycoproteins critical for mitochondrial function, leading to dysfunction in the respiratory chain. Impaired electron transport causes electrons to leak at complexes I and III, reacting with oxygen to form reactive oxygen species (ROS). These ROS damages lipids, proteins, and DNA, further compromising mitochondrial integrity and exacerbating cellular dysfunction. Ascorbyl palmitate (AP), a fat-soluble antioxidant, shows promise as a therapeutic approach by reducing ROS. By stabilizing lipid membranes and scavenging ROS, AP supports mitochondrial integrity and function. Patients with PMM2-CDG treated with ascorbyl palmitate (AP) have shown promising improvements, including enhanced energy levels, better motor function, and reduced fatigue. While these outcomes are early, they suggest AP could help mitigate some of the debilitating symptoms of this condition, improving overall quality of life. Summary provided by REPO4EU