Science-Switzerland’s Post

Specially designed nanocomplexes were found to significantly reduce tumour size in mice without harming vital organs 🔍 Building on momentum from a previous study, Yi Yan Yang of A*STAR Bioprocessing Technology Institute (BTI) led her colleagues and collaborators from the Bioinformatics Institute, A*STAR (BII), Institute of Molecular and Cell Biology (IMCB) and the IBM Almaden Research Centre in formulating next-generation nanocomplexes that effectively target and neutralise cancer cells. When tested on mouse models, they discovered that the treatment had successfully curbed the growth of both drug-susceptible and drug-resistant human breast cancer cells ✅ Recognising the potential impact of this innovation in drug delivery, Yang remarked: “Our anti-cancer polycarbonates may prevent or delay the development of cancer metastasis and drug resistance.” Head to the comments section for the link to the complete article 👇 --- #scicomm #science #technology #STEM #research #innovation #ASTAR #BTI #BII #IMCB #HHP #cancer #nanoparticles #drugdelivery #tumors

Scientists uncover an intermediate reversible state in a cell before it fully commits to the process of dividing itself into two new cells. This discovery of a fundamental aspect of cell biology could have implications for understanding cancer, wound healing, and other cell division-related processes. Researchers led by Dr. Tobias Meyer of Weill Cornell Medicine developed new tools allowing them to track over time the activation state of E2F, a transcription factor protein long known as the master switch for initiating division in mammalian cells. They found unexpectedly that E2F, before being fully activated, can remain in a potentially lengthy state of partial and reversible activation that may end in full commitment to cell division or a reversion to the usual, non-dividing, “quiescent” state. Although the role of this pre-commitment state of cell division is not yet entirely clear, it appears to be a safety mechanism to avoid inappropriate cell division, and may also activate DNA-repair functions. https://bit.ly/3XQOj3j

📚 SCIENTIFIC POSTER | 𝗥𝗲𝗮𝗹-𝘁𝗶𝗺𝗲 𝗺𝗼𝗻𝗶𝘁𝗼𝗿𝗶𝗻𝗴 𝗼𝗳 𝗶𝗻𝘁𝗿𝗮𝗰𝗲𝗹𝗹𝘂𝗹𝗮𝗿 𝗰𝗵𝗮𝗻𝗴𝗲𝘀 𝗶𝗻 𝟯𝗗 𝗯𝗶𝗼𝗹𝗼𝗴𝘆 𝗿𝗲𝘀𝗲𝗺𝗯𝗹𝗶𝗻𝗴 𝗿𝗲𝗹𝗲𝘃𝗮𝗻𝘁 𝗽𝗵𝘆𝘀𝗶𝗼𝗹𝗼𝗴𝗶𝗰𝗮𝗹 𝗽𝗿𝗼𝗰𝗲𝘀𝘀𝗲𝘀 𝗶𝗻 𝗱𝗿𝘂𝗴 𝗱𝗶𝘀𝗰𝗼𝘃𝗲𝗿𝘆 🔔ARRAYS FOR CELL NANODEVICES, SL - A4CELL just presented a poster at ELRIG UK Research and Innovation 2024 conference 🧫This poster highlights the value of our #SPAchip platform aka 𝘓𝘢𝘣-𝘪𝘯-𝘢-𝘤𝘦𝘭𝘭 𝘥𝘦𝘷𝘪𝘤𝘦 to study cancer, neurodegeneration, and metabolic diseases in spheroids 👨🔬 👩🔬 Thanks to our scientific team for their excellent work! Marina Martínez Bartolomé, Ph.D., Irene Palacios Doiztúa, Antonio Quílez-Álvarez and Alberto Hernandez ❓Are you ready to try our SpheroCHECK detection kit in your #3Dmodel? Feel free to reach out or comment below #DrugDiscovery #LiveCellImaging #LiveCellAnalysis

Excited about pushing your mass spec proteomic research to new heights? Recent breakthroughs in reducing input requirements have made Laser Capture Microdissection (LCM) an essential tool for enriching tissue samples in mass spec studies. Gone are the days when low tumor load samples were beyond reach due to high input demands and sample heterogeneity. Thanks to Accuva Cellect LCM, with its single-cell resolution, even low tumor load samples in early-stage research are now accessible. Whether you're unraveling mysteries in cancer biology, neurodegenerative diseases, or developmental biology, laser microdissection opens doors to previously unexplored samples. The Accuva Cellect can isolate target cells from complex tissues, unveiling molecular signatures and uncovering novel biomarkers with unmatched precision. Ready to propel your proteomic research forward? Schedule a demonstration AccuvaCellect@laxcoinc.com or learn more here: https://lnkd.in/eEmqwP3n #MassSpec #Proteomics #Research #Innovation #LCM #AccuvaCellect #Laxcoinc

Researchers use generative AI to discover a new class of Polθ inhibitors for BRCA-deficient cancers. ◾ DNA Polymerase Theta (Polθ) provides a potential synthetic lethal relationship in BRCA-deficient tumors which are particularly prevalent in triple-negative breast cancers (11-16%) and ovarian cancers (10-15%). ◾ Now, researchers from Insilico Medicine have discovered a new class of Polθ inhibitors featuring central scaffolding rings, designed using Chemistry42. ◾ The AI-enabled molecules exhibited significant enzymatic and cellular potency and promising druglike properties, pointing to a novel strategy for targeting Polθ. ◾ The research was published in Bioorganic & Medicinal Chemistry, an Elsevier peer-reviewed journal. *Link to release in comments #ai #genai #drugdiscovery #brca #cancer #oncology #biotech #research

Exciting to share that our new #multiomics analytic method, #MOMLIN, just been published in Briefing in Bioinformatics. #MOMLIN was applied to predict enhanced #drug responses and their underlying biology. Article link: https://lnkd.in/gEc8KF7y

Physiological insights gleaned from the fluid dynamics model behind ShearFAST's user friendly calculator. Fluid flow in the ovarian cancer microenvironment may be a double-edged sword, simultaneously reducing cancer cell viability but also increasing genomic instability, which could be a factor enhancing metastatic potential. Link:https://lnkd.in/enaWDbJs Check out ShearFAST here: https://lnkd.in/eR5wgbna #ShearFAST #Science #Biology #physics #FluidShearStress #ResearchAdvancements #ScientificTools #OpenScience #Collaboration #fluiddynamics #fluid #cancer Corning LifeScience Greiner Bio-One International VWR, part of Avantor Sigma-Aldrich SARSTEDT Group Cole-Parmer Thermo Fisher Scientific, Lonza Agilent Technologies

Mini Magnetic Submarines Against Liver Cancer. Using magnetism and gravity, Montreal researchers are remotely guiding a microscopic “submarine” to transport drugs to tumors. The target of the team, led by Gilles Soulez, a radiologist and researcher at the CHUM - Centre hospitalier de l'Université de Montréal, is hepatocellular carcinoma, a liver cancer responsible for 700,000 deaths per year worldwide. Read: https://lnkd.in/eEzPvrTW #sciencesdelavie #biotechnology #biotechnology #innovation #innovations #research #sciences #medicaments #research #drugresearch #laboratories #labs #chemistry #chemistry #biology #biologie #biopharma #rna #rnatherapeutics #arn #revolution #happy

Insightful Seminar on Nanoparticle-Mediated Hyperthermia 🌐 We're excited to share highlights from a recent online seminar titled "Benefits of Local Hyperthermia Mediated by Nanoparticles Under NIR Irradiation," given by Dr. Francisco Jose Teran Teran from NANOTECH SOLUTIONS, Spain. This enlightening seminar took place online on June 28th and was attended by the entire STRIKE network. Dr. Teran provided an in-depth introduction to the use of nanoparticles to induce hyperthermia. A key focus was on the application of this technology in oncology, where it shows significant promise for targeting cancer cells more precisely, reducing side effects, and improving treatment efficacy both in vitro and in vivo. The seminar was organized to help us in STRIKE network to understand how to leverage this cutting-edge technology in our own research. The insights gained will be instrumental in advancing our studies and developing more effective treatments for osteosarcoma and other cancers. We are grateful for Dr. Teran's valuable insights and the opportunity to expand our knowledge on this topic. Looking forward to more such informative sessions! #Innovative #OpenSicence #research #HorizonEU #MSCA #Osteosarcoma #nanomaterials #nanomedicine #Nanotechnology #Hyperthermia #STRIKENetwork #Innovation

【γδ 𝐓 𝐂𝐞𝐥𝐥 𝐓𝐡𝐞𝐫𝐚𝐩𝐲 𝐜𝐚𝐧 𝐄𝐟𝐟𝐞𝐜𝐭𝐢𝐯𝐞𝐥𝐲 𝐈𝐧𝐡𝐢𝐛𝐢𝐭 𝐌𝐞𝐬𝐨𝐭𝐡𝐞𝐥𝐢𝐨𝐦𝐚 𝐓𝐮𝐦𝐨𝐫 𝐆𝐫𝐨𝐰𝐭𝐡 𝐛𝐲 𝐈𝐧𝐝𝐮𝐜𝐭𝐢𝐨𝐧 𝐨𝐟 𝐏𝐲𝐫𝐨𝐩𝐭𝐨𝐬𝐢𝐬🐁】   Mesothelioma is a highly aggressive tumor found in the pleural cavity that can be induced by exposure to asbestos. Unfortunately, diagnosis often occurs at an advanced stage, leaving patients with limited conventional therapeutic options and unfavourable outcomes.   In this research, 𝐃𝐫 𝐂𝐇𝐄𝐔𝐍𝐆 𝐊𝐚 𝐋𝐨𝐨𝐧 𝐀𝐥𝐥𝐞𝐧, Assistant Professor in the Department of Biology at HKBU, collaborated with the Center for Medical Innovation, Nagasaki University to establish a tumour mouse model that mimics the real-life scenario of mesothelioma in humans. This model was used to test the combination therapy of γδ T cells plus anti-PD-1, both of which have shown limited effectiveness against this type of cancer.   🔎Read more: https://bityl.co/O2u6   #HKBU #HKBUScience #HKBUSCI #BIOL #Biology #浸會大學 #浸大理學院 #生物系