Sergio Cifuentes Canaval’s Post

Many young women who are diagnosed with #breastcancer are interested in future #fertility, however, many #cancertreatments can impair an individual’s fertility and their ability to carry a pregnancy. According to a new study, most women who attempted to conceive following treatment for breast cancer were able to become pregnant at least once and have a live birth with factors such as younger age at diagnosis, financial comfort, and having undergone fertility preservation associated with a higher chance of becoming pregnant. Researchers analyzed data from the prospective Young Women’s Breast Cancer Study of 1213 patients aged 40 years and younger who received a diagnosis of breast cancer between the years 2006 and 2016. At a median follow-up of 11 years, 197 patients reported that they attempted pregnancy. In this group, 73% became pregnant at least once, with 90% of these patients reporting having at least 1 pregnancy that resulted in a live birth. Data showed that factors associated with a higher chance of becoming pregnant included: being younger at the time of diagnosis; being financially comfortable, and having undergone fertility preservation. https://lnkd.in/eyGwPHXq #CancerResearch

Fertility & pregnancy prospects in females with breast cancer are promising! Younger age is one factor that fares better against the odds, just like in any pregnancy. Read the article for more information! #breastcancerawareness #mythsbusted #fertilityawareness #obgyn #healthcare

Hypertension, Antihypertensives, and Childhood Cancer Risk Our partners, Drs. Pei-Chen Lee and Julia Heck, recently published a paper looking at the relationship between maternal hypertension and preeclampsia, antihypertensive medication use during pregnancy, and pediatric cancer risk using data from Taiwanese health registries. The results from this study emphasize the impact of a mother’s health and in-utero environment on childhood cancer risk. Read more in the article below: https://lnkd.in/gM-WkVSa

Cancer During Pregnancy: Multidisciplinary Management The most common malignancies diagnosed during pregnancy include breast cancer, thyroid cancer, gynecological cancers, melanoma and hematological malignancies. The co-occurrence of pregnancy and cancer can arise in various settings, including a new diagnosis or recurrence of a prior cancer. Read more on our blog: https://lnkd.in/dvvzJz6G

#breastcancer #pregnancy #cancerresearch #oncology https://lnkd.in/g33hhet5 Highlights • Breast cancer in pregnancy had higher proportions of luminal HER2-positive, HER2-positive, and triple-negative subtypes. • Women diagnosed in the second and third trimesters, and first year after delivery had significantly worse prognosis. • The worse prognosis remained significant only for the second trimester after adjusting for tumour biology and stage.

Real-world experience of bimekizumab for adult patients with plaque psoriasis: A 52-week multicenter retrospective study https://lnkd.in/e36V9nPe Bimekizumab is an interleukin (IL)-17A/IL-17F inhibitor, approved in the US for treatment of plaque psoriasis - 1-year real-world retrospective multicenter study included 87 adult patients with plaque psoriasis - Mean age 45.6 years, 59.8% male - At week 52±6: 87.3% achieved an IGA score clear or almost clear - 87.4%, 81.6%, and 70.1% of patients achieved 75%, 90% and 100% improvements in PASI respectively) - mean PASI improvement 93.9% - mean BSA improvement 94.2%) - patients with previous exposure to IL-17 inhibitors PASI90, and PASI100 responses were 70.7% and 63.4% - Biologic-naïve patients had higher statistically significant responses - 13.8% treatment-related AEs were identified, including candidiasis 5.7% and folliculitis 3.4% - 8% treatment discontinuations: lack of efficacy (n=4), anxiety (n=1) and inflammatory bowel disease (n=1) and pregnancy (n=1)

Have you or your partner thought about the effect of breastfeeding on cancer risk? It's not a topic that often even enters our mind when we are starting our family, and worrying about risk while nursing was never something I considered. For those who know they have an elevated risk for hereditary cancer, this survey study asks questions about the decision-making process on timing of pregnancy, breastfeeding, breast cancer screening, and risk-reducing surgery. If you or someone you know has an inherited mutation related to increased breast cancer risk, please share this study.

The lack of inclusion of pregnant women in clinical studies can complicate clinical decision making and affect outcomes. AI and RWE have much to contribute to this space: Our new #ASCO24 poster examines pregnancy loss among patients with cancer. #MaternalHealth #CancerResearch