"RNA will define a generation of science" New opinion piece in the NYT on the "under-appreciated" potential of RNA: https://lnkd.in/eSddFEa9
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"RNA will define a generation of science" New opinion piece in the NYT on the "under-appreciated" potential of RNA: https://lnkd.in/eSddFEa9
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Chief Medical Officer Biotech / Medical affairs and clinical development director / Public-private partnership in science & biotech / Women leadership/Health biotech advisor
“RNA research may also be helping us rewrite the future”. Our attention and efforts must be focused in this. Great advances in treatment of life threatening diseases ahead! Please do not miss this revealing article to perceive RNA based therapies value.
"RNA will define a generation of science" New opinion piece in the NYT on the "under-appreciated" potential of RNA: https://lnkd.in/eSddFEa9
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Very nice opinion piece about RNA by Tom Cech.
Associate Professor researching the structure and function of the telomerase RNP and how it controls senescence/aging by regulating telomere length
Tom Cech just penned here a great short piece in the NY Times about something he understands incredibly well — RNA! "...Although most scientists now agree on RNA's bright promise, we are still only beginning to unlock its potential. Consider, for instance, that some 75 percent of the human genome consists of dark matter that is copied into RNAs of unknown function. While some researchers have dismissed this dark matter as junk or noise, I expect it will be the source of even more exciting breakthroughs. We don’t know yet how many of these possibilities will prove true. But if the past 40 years of research have taught me anything, it is never to underestimate this little molecule. The age of RNA is just getting started." https://lnkd.in/e9An265Y
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Exciting developments in RNA research. Nanopore sequencing stands out as the sole option for sequencing native RNA at single molecular resolution. Through significant advancements in dRNA sequencing, Oxford Nanopore is set to drive the RNA revolution forward. #RNAsequencing #Nanopore #OxfordNanopore
“The age of RNA is just getting started” Libby Snell Lakmal Jayasinghe Clive Brown Rosemary Sinclair Dokos Oxford Nanopore Technologies
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RNA was once molecular biology’s also-ran. A new book puts it centre stage—and explores its role in life’s origins, as well as its medical uses https://lnkd.in/eUCvEAZq
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Current methods for mapping RNA modifications -- the epitranscriptome -- are limited, with sequencing only able to detect a small number of these modifications. How could #AI help? Atomic founder Raphael Townshend provided some insight to The National Academies of Sciences, Engineering, and Medicine. https://lnkd.in/egBkkYTt #epitranscriptome #RNA #science #engineering #RNAtherapeutics
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Managing Director - Commercial Institutional Investment Sales, Finance and Research at Brookwood-Starboard Commercial
The Long-Overlooked Molecule That Will Define a Generation of Science From E=mc² to splitting the atom to the invention of the transistor, the first half of the 20th century was dominated by breakthroughs in physics. Then, in the early 1950s, biology began to nudge physics out of the scientific spotlight — and when I say “biology,” what I really mean is DNA. The momentous discovery of the DNA double helix in 1953 more or less ushered in a new era in science that culminated in the Human Genome Project, completed in 2003, which decoded all of our DNA into a biological blueprint of humankind. DNA has received an immense amount of attention. And while the double helix was certainly groundbreaking in its time, the current generation of scientific history will be defined by a different (and, until recently, lesser-known) molecule — one that I believe will play an even bigger role in furthering our understanding of human life: RNA. You may remember learning about RNA (ribonucleic acid) back in your high school biology class as the messenger that carries information stored in DNA to instruct the formation of proteins. Such messenger RNA, mRNA for short, recently entered the mainstream conversation thanks to the role they played in the Covid-19 vaccines. But RNA is much more than a messenger, as critical as that function may be. https://lnkd.in/gRFcQupx
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A genomic smart watch 🧬 Jay Shendure is one of the most creative scientists in the field of genomics. My time working at UW Genome Sciences was extremely formative for understanding the enormous potential of the NGS revolution beyond personalized health. He believes that NGS is "emerging as a broadly enabling microscope for the measurement of biological phenomena." That thesis is more true each day. This week, it was announced that a new Chan Zuckerberg Biohub Network is being formed in Seattle to accelerate ideas from the Jay Shendure lab around real-time sensing of cells—akin to a "genomic smart watch." If you're curious about what this means in practice, I wrote two CoB posts two years ago (time flies 😅) on this technology: 1. DNA Ticker Tape https://lnkd.in/gfYG487c 2. Multiplex genomic recorders https://lnkd.in/gVAVhvJg Here's a news article about the new center: https://lnkd.in/gstAW8gx Between Institute for Protein Design, University of Washington, UW Genome Sciences, this new biohub, and the growing number of great companies, I wouldn't sleep on Seattle biotech...
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Writer / Literast / Artist / Comedian / Alpha Geek / Tech Witch / AI Whisper / Prompt Engineer / Timelord
Untapped power: Logical operations using RNA droplets https://lnkd.in/g865BtYK
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Embarking on a journey with new technology and experiments can be a learning curve. 🚀10x Genomics is here to support you in navigating that curve and accelerating your path to incredible Xenium #singlecellspatial data. Dive into the latest blog post, featuring insightful Q&As from recent publish, 'Getting started with Xenium In Situ assays and designing custom panels.' Gain valuable information to prepare for your Xenium projects and unlock the full potential of spatial data analysis. Check more on : https://lnkd.in/dbY99rYB #AGBL #Xenium #SpatialAnalysis #SingleCellResearch #ScienceInnovation"
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🆕 @molecular systems biology by Stefanie Luecke, PhD et al. | decoding #dynamics of #NFκB and #p38 in 🐁 #MPhi via life cell imaging and bioinformatics | not every ligand is signalling equally #Macrophages sense #pathogens and orchestrate specific immune responses. #Stimulus #specificity is thought to be achieved through #combinatorial and #dynamical #coding by #signaling #pathways. While NFκB dynamics are known to encode stimulus information, dynamical coding in other signaling pathways and their combinatorial coordination remain unclear. Here, we established live-cell microscopy to investigate how NFκB and p38 dynamics interface in stimulated macrophages. Information theory and machine learning revealed that p38 dynamics distinguish cytokine TNF from pathogen-associated molecular patterns and high doses from low, but contributed little to information-rich NFκB dynamics when both pathways are considered. This suggests that immune response genes benefit from decoding immune signaling dynamics or combinatorics, but not both. We found that the heterogeneity of the two pathways is surprisingly uncorrelated. Mathematical modeling revealed potential sources of uncorrelated heterogeneity in the branched pathway network topology and predicted it to drive gene expression variability. Indeed, genes dependent on both p38 and NFκB showed high scRNAseq variability and bimodality. These results identify combinatorial signaling as a mechanism to restrict NFκB-AND-p38-responsive inflammatory cytokine expression to few cells. https://lnkd.in/eRw2HPFY John Gordon Dr Neil Bodie Sarah Holland Scott N. Freeman, PhD Christopher Ring Brent Alexander Brown Chinua Imarogbe Dr. Alexander Ariel Padrón González Eduardo Petazze Eugenia Praloran
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Chief Medical Officer Biotech / Medical affairs and clinical development director / Public-private partnership in science & biotech / Women leadership/Health biotech advisor
2mo“RNA research may also be helping us rewrite the future”. Our attention and efforts must be focused in this. Great advances in treatment of life threatening diseases ahead!