Sino Biological, Inc.’s Post

Antibody fragments like Fab, ScFv, and VHH are emerging stars in antibody drug development, utilized both as standalone molecules and as building blocks of bispecific antibodies. However, their production and engineering face numerous challenges, including issues related to yield, purity, throughput, and stability. Join our upcoming webinar, “Innovative Production and Engineering Strategies for Fab, ScFv & VHH” to learn cutting-edge strategies for overcoming these challenges, tailored to the distinctive characteristics of Fab, ScFv, and VHH. We’ll provide key insights into molecular design, HTP high-titer CHO transient and stable pool production, and effective purification methods to accelerate your development of antibody fragments. Register Now ▶️ https://lnkd.in/eUyUGSie #antibodyproduction #antibodytherapeutics #drugdevelopment #proteinscience #bioindustry #WuXiBiologics #ScFvantibody #VHH #FabAntibody

Dive into the future of antibody production with WuXi Biologics' webinar on April 24, 2024! Unlock the potential of Fab, ScFv, and VHH with insights from Dr. Jiansheng Wu. Don't miss out!#InnovativeBiologics #WuXiBiologics #AntibodyProduction #BiotechWebinar🔗

Lateral flow assays (LFA) are one of the most common immunoassay formats for in vitro diagnostics (IVD). A thorough comprehension of how antibodies and antigens interact, coupled with an assessment of antibody quality, is crucial for the successful development and optimization of LFAs. In the product development of LFAs, label-free approaches are used during, assay development, assay optimization, and quality control. Access the whitepaper: https://ow.ly/g5oH50QGLxb #OctetBLI #IVD #antibody #kinetics #immunoassay #lfa #laterflow

As JP Morgan Healthcare Conference for 2024 ends, a hot topic has been #ADCs and #precisionmedicines. If you are looking for the next precision targeting molecule for development in the ADC, #radioligand, or #genetherapy space, come and talk to us about #Optimer.    Optimers are oligo-based antibody alternatives with small size for rapid tissue penetration, tuneable kinetics for optimized target vs. systemic exposure, and high affinity and selectivity for precision-targeted cargo.    Compatible with diverse linkers and giving controlled chemistry for accurate drug loading, come and talk to us if you are seeking new solutions to support your pipeline.  https://lnkd.in/eS9-YTHZ

When you replace the drug in your Antibody Drug Conjugate (ADC) with a radionuclide or fluorescent dye, it is possible to visualize whole-body biodistribution.   Our method allows you to show targeting and the mechanism of action of your ADC in (pre) clinical trials. Moreover, you can show off-target accumulation that will allow you to predict side effects, without the risk of potential toxic effects of your ADC.   In the figure below, you can see the conjugation workflow of fluorescent-labeled ADCs.   Do you want to know more about labeling your ADC? At TRACER, we’re experienced in ADC labeling and the possible advanced analytical methods for your ADC clinical trials.   #molecularmonday #ADC #antibodydrugconjugate #antibodylabeling

Antibody-drug conjugates (ADCs) stand out as innovative biotherapeutics, but understanding their ADME properties during the discovery and development stages can be complex. This upcoming webinar can help! Join us on March 20th from 11:15 to 11:45 am, EST, as our expert Dr. Liping Ma from WuXi AppTec will share insights and strategies for ADC development at AAPS’s eCHALK webinar (free registration: https://lnkd.in/gn9Akzvr. I am happy to be the moderator of this webinar). Topics include: ✅ Payload release mechanisms ✅ Identification of catabolites in various in vitro systems ✅ Detection of drug–antibody ratios (DAR) ✅ The implementation of an integrated bioanalysis platform catering to both small and large molecules #aapscomms #adc #drugdiscovery #drugdesign #bioanalytical #dmpk #adme

Ask our Experts on May 30th! Join us in our upcoming webinar on LC-MS based antibody characterization, led by our experts Dr. Jinrui Gan and Anthony Stajduhar. 📆 May 30th 2024 ⌚ 11:00AM EST Register below! https://hubs.li/Q02wF-ZJ0 Have any questions for our panelists? Comment them below ⬇️ #AntibodyDevelopment #AntibodyCharacterization #LC-MS #Proteomics

Curious about how mast cells forecast injection site reactions? Find out in our updated blog post! Our latest blog explores the fascinating world of mast cells, shedding light on their intricate involvement in immediate and delayed injection site reactions. Discover how mast cell-specific receptors, like MRGPRX2, are involved in pseudo-allergic reactions associated with injection of biologics. Gain insights into the molecular mechanisms driving mast cell activation and their implications for drug safety and patient comfort. 👉🏻https://bit.ly/3VaO9Re

Enhancing GPCR screening with customized signalling assays Optimizing GPCR assays can be challenging. Learn how SB Drug Discovery’s extensive collection of G protein tools facilitate robust, reliable data for GPCR drug discovery screening. Our extensive cell signalling experience helps deliver custom solutions for the most challenging receptors. https://lnkd.in/ej3iuSUC #GPCR #GProtein #DrugDiscovery #AssayDevelopment #SBDrugDiscovery #SygnatureDiscovery

This was a really great webinar and I'd thoroughly recommend it particularly to anyone starting out on ADC. There can be a lot to consider with bioconjugation even of simple molecules such as biotin for in vitro use - e.g. where is it going to bind and how many biotin will bind as these can have their own effects on the product, but the pharmacokinetics of ADC's requires so much more consideration! If you're into labelling site, hydrophobicity and DAR (Drug antibody ratio) as well as having tools to change therapeutic clearance, or protect payload cleavage sites (and more!) do have a watch. If you're interested in biosimilar antibodies such as those from Absolute Antibody or Bio X Cell for payload delivery, then the BioDesign tools and team at Vector Laboratories, Inc. could be a great web page to bookmark! https://lnkd.in/eUA__dHp. #2BScientific #Hereforyou #AntibodyDrugConjugates