🟢 Don't miss out! Our promotion for 15% off our full-length proteins and antibodies ends on February 15! 🟢 Did you know that around 60% of drugs target transmembrane proteins? However, challenges like low expression and purification issues have limited their use. Sino Biological is at the forefront, addressing these challenges. With a focus on multi-pass transmembrane proteins, we've established three innovative platforms – virus-like particles (VLP), detergent micelle, and nanodisc – providing key materials for early-stage drug development. Check out our custom services and range of multipass transmembrane proteins offered, including GPCRs (GPRC5D, CXCR4, SSTR2, CB2), Claudins, and more. https://ow.ly/sNcQ50QysTu #DrugDevelopment #TransmembraneProteins #Promotion
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The poster sessions at #WRIB were highly popular this year with long lines, so if you didn't get a chance to speak with Jing L. about her presentation on Anti-Drug Antibody (ADA) Assay for XPro1595, a self-assembling trimer: alternatives to standard bridging or ACE approaches, be sure to stop by our booth #24 and speak to Jing. You can always set up time to meet as well by clicking here: https://bit.ly/3Uuv6lQ #drugmetabolism #pharmacokinetics #lifescience #invitro #biotransformation #dmpk #pharma #biotech #research #drugdevelopment #bioanalysis #bioanalytical #immunoassay #lcmsms #lcms #hrms #pharma #adme #oligonucleotides #monoclonalantibodies #rnabasedtherapeutics
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Are you interested in learning how to identify and optimize compounds that can bind to difficult-to-drug pockets, or do you want to discover the hidden potential of macrocyclic compounds in your drug discovery projects? If yes, Explore Spark’s ‘Macrocyclization’ experiments within your drug discovery projects. Read the article https://lnkd.in/ekGTKmjG, to know more about how to drug difficult binding pockets using Spark’s ‘Macrocyclization’ experiments and learn several advantages Macrocyclic compounds can present in your discovery projects. #DMTA #drugdiscovery #drugdesign #computationalchemistry #compchem #medicinalchemistry #medchem #CADD #cheminformatics #Spark #macrocyclization
Find targets for typically ‘difficult to drug’ binding pockets, by using Spark’s ‘Macrocyclization’ experiments within your drug discovery projects. Macrocyclic compounds can present several advantages such as: ✨ Diverse functionality ✨ Favorable drug-like properties ✨ Increased selectivity Find out how to drug difficult binding pockets using ligand macrocyclization: https://lnkd.in/ekGTKmjG #DMTA #drugdiscovery #drugdesign #computationalchemistry #compchem #medicinalchemistry #medchem #CADD #cheminformatics
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Protein L Mix-N-Go™ ELISA kit enables accurate assessments of residual Protein L impurity in your antibody fragment drug products, which can remain bound to leached Protein L post-purification. The Mix-N-Go kit incorporates a proven single-step sample treatment to dissociate Protein L from antibody fragment drug product without boiling samples and the associated centrifugation step. These improvements increase the robustness of the method and simplify the assay protocol. The kit is very sensitive and detects Protein L levels <600 pg/ml. Please use Sample Diluent, Item No. G028 with this kit; also included in the kit. . To know more write to us at inquiry@zellebiotech.com . #CygnusTechnologies #HostCellProteins #downstreamProcessing #immpurityanalysis #FabFragment #scFV #celltherapy #genetherapy #Biotech #biopharma #Innovation #ResearchandDevelopment #zellebiotechnology #zelleras
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Find targets for typically ‘difficult to drug’ binding pockets, by using Spark’s ‘Macrocyclization’ experiments within your drug discovery projects. Macrocyclic compounds can present several advantages such as: ✨ Diverse functionality ✨ Favorable drug-like properties ✨ Increased selectivity Find out how to drug difficult binding pockets using ligand macrocyclization: https://lnkd.in/ekGTKmjG #DMTA #drugdiscovery #drugdesign #computationalchemistry #compchem #medicinalchemistry #medchem #CADD #cheminformatics
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Chief Scientist EPOC Scientific | Senior Discovery Science Innovator | Exploratory Drug Discovery (Peptides, Degraders, NP, Small Molecules) | Med Chem | Technology Platforms | CRO Management
A very nice paper from a team at BMS in BioRxiv that developed a balanced permeability index (BPI). The data sets used were not classified into modalities. How does the BPI work for macrocycles and macrocyclic peptides? #permeability #cellularuptake Peptide Drug Hunter Consortium Index.https://https://lnkd.in/d4Z2gnCT
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Technical Account Manager | Supporting Custom API cGMP Manufacturing | Custom Synthesis | Large and Small Molecule | CMC Biotech
Are you at TIDES USA this week? Did you know you could schedule a meeting with me through the ConnectMe app? I would love to talk with you about GLP oligonucleotide method validations, drug product release and mRNA method development, among other things. If you are at TIDES and looking for a partner in all things nucleic acids or peptides, stop by booth #1116 and lets discuss! #PaceLifeSciences #PeopleAdvancingScience #Oligo #GMP #TIDESUSA
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Peptide Drug Discovery Webinar One Week Away! Register Today: https://buff.ly/4ayEmKy Register today, and join us on Wednesday, Jun 19, 2024 at 10am ET / 7am PT / 4pm CET online to explore peptide drug discovery innovations in your preferred time zone. #Webinar #PeptideDrugDiscovery #PeptideDrugs #SyntheticPeptide #PeptidePlatform #DrugDiscovery
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The highly popular poster presented at WRIB 2024 by Jing L., Principal Scientist on Anti-Drug Antibody (ADA) Assay for Xpro 1595, A Self-Assembling Trimer: Alternative to Standard Bridging Approach is now available for viewing here with no waiting! https://bit.ly/4cDA0Dx #drugmetabolism #pharmacokinetics #lifescience #invitro #biotransformation #dmpk #pharma #biotech #research #drugdevelopment #bioanalysis #bioanalytical #immunoassay #lcmsms #lcms #hrms #pharma #adme #oligonucleotides #monoclonalantibodies #rnabasedtherapeutics
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Don’t miss our Principal Scientist, Jing Liu’s poster presentation on Tuesday, May 7th at this year’s #WRIB event in San Antonio. Key learnings from Jing’s presentation will be: • Self-assembling drug XPro159 is challenging for standard ADA format like Bridging or ACE • Presentation of a novel format, ACE-AG, designed to solve the problem • The format mitigated the high background from the self-assembly of the drug and provided excellent sensitivity. It also demonstrated drug tolerance and robustness against endogenous target interference. Want to set up a time to meet at WRIB or if you’re not attending and want to chat, just click here: https://bit.ly/3Uuv6lQ #drugmetabolism #pharmacokinetics #lifescience #invitro #biotransformation #dmpk #pharma #biotech #research #drugdevelopment #bioanalysis #bioanalytical #immunoassay #lcmsms #lcms #hrms #pharma #adme #oligonucleotides #monoclonalantibodies #rnabasedtherapeutics
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Pursuing biomedical engineering in Sri Ramakrishna college of engineering| | Seeking Internship Opportunities
Delighted to share that I recently attended the FIP digital event on "𝗔𝗱𝘃𝗮𝗻𝗰𝗲𝗺𝗲𝗻𝘁𝘀 𝗶𝗻 𝗜𝗻𝗵𝗮𝗹𝗮𝗯𝗹𝗲 𝗡𝗮𝗻𝗼-𝗗𝗿𝘂𝗴 𝗗𝗲𝗹𝗶𝘃𝗲𝗿𝘆 𝗦𝘆𝘀𝘁𝗲𝗺𝘀 𝗳𝗼𝗿 𝗧𝗮𝗿𝗴𝗲𝘁𝗲𝗱 𝗟𝘂𝗻𝗴 𝗧𝗵𝗲𝗿𝗮𝗽𝘆" hosted by International Pharmaceutical Federation (FIP). 𝗞𝗲𝘆 𝗟𝗲𝗮𝗿𝗻𝗶𝗻𝗴𝘀 : 𝟭) Anatomy and functions of lungs. 𝟮)Challenges in targeted drug delivery to the lungs: ★Achieving precise delivery to specific lung regions. ★Overcoming the mucus barrier and pulmonary clearance mechanisms. ★Ensuring stability and bioavailability of nanoparticles in the lung environment. 𝟯)Utilization of natural polymers like alginate, chitosan, and gelatin for polymer screening in lung drug delivery, as well as the use of synthetic polymers such as PLGA, PLGA-CS, and PLGA-PEG. Thanks to FIP for this intriguing webinar! #internationalpharmaceuticalfedaration #drugdelivery #nanotechnology #respiratorydisorders
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